Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions
Clinical Medicine Research
Volume 5, Issue 3, May 2016, Pages: 39-44
Received: Feb. 20, 2016; Accepted: Apr. 25, 2016; Published: May 13, 2016
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Authors
Galiya Ibadullayeva, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Volodimir Grudko, Pharmaceutical Faculty, National Pharmaceutical University, Kharkov, Ukraine
Аssyl Boshkayeva, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Zuriyadda Sakipova, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Talgat Dzalgasbayev, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Gulbaram Ustenova, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Kaldanay Kozhanova, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Nazerke Uristemkhankyzy, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Eduard Bissenbaev, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Nurgan Tussupova, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Sholpan Mulkibayeva, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Ilyas Tazabekov, Pharmaceutical Faculty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
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Abstract
We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.
Keywords
Tablets, CO2-Extracts, Quality Indicators, Camphor, Carotenoids, Acorus Calamus, Calendula Officinalis
To cite this article
Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, Gulbaram Ustenova, Kaldanay Kozhanova, Nazerke Uristemkhankyzy, Eduard Bissenbaev, Nurgan Tussupova, Sholpan Mulkibayeva, Ilyas Tazabekov, Pharmaceutical Development of the Combined Structure of the Tablets "Exkair" from Various Phytocompositions, Clinical Medicine Research. Vol. 5, No. 3, 2016, pp. 39-44. doi: 10.11648/j.cmr.20160503.15
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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