Clinical Medicine Research

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Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study

Received: 11 April 2017    Accepted: 20 April 2017    Published: 01 June 2017
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Abstract

Ageing in men is associated with increased prevalence of cardiovascular risk factors and benign prostatic hyperplasia (BPH) with both entities possibly representing downstream manifestations of a common pathogenesis. There is paucity of data on the association of BPH and left ventricular hypertrophy (LVH). This study evaluated relationship between prostate volume, common cardiovascular risk factors and LVH. It was a cross sectional, prospective, hospital-based study. Thirty patients with benign prostatic enlargement (BPE) and 30 age- matched male controls without BPE were studied. All the subjects had clinical, biochemical, prostate ultrasound and echocardiographic evaluation done. SPSS IBM 20 was used to analyze data. Mean age was 65.60 ± 8.11 years (range: 54-82years). Subjects with BPE compared to those without did not significantly differ in age (66.50± 7.75 vs. 64.70±8.49; p=0.39). Significantly higher percentage of subjects with BPE had abnormally low HDL-cholesterol and high blood pressure compared with subjects without BPE. Eight (26.7%) of subjects with BPE in contrast to none of the subjects without BPE had metabolic syndrome (Chi2 = 9.231; p=0.002). Left ventricular mass index were significantly higher in subjects with BPE than in those without. None of the subjects without BPE as compared with 7 (23.3%) of subjects with BPE had echocardiographic determined LVH. Echocardiographic indices that significantly correlated with prostatic volume were: LVPWd (r=0.326, p= 0.011), IVSTd (r= 0.267, p=0.039), LVMI(r=0.308, p= 0.017), LAD (r= 0.494, p <0.0001) and AOD (r= 0.352, p= 0.006). The conclusion was that BPE is associated with increased left ventricular mass index and metabolic syndrome, mostly driven by elevated blood pressure and low serum HDL-cholesterol.

DOI 10.11648/j.cmr.20170604.11
Published in Clinical Medicine Research (Volume 6, Issue 4, July 2017)
Page(s) 121-126
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Benign Prostatic Hypertrophy, Prostatic Volume, Left Ventricular Hypertrophy, Metabolic Syndrome, Left Ventricular Mass Index

References
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[2] Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984; 132:474–9.
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[4] Madersbacher S, Alivizatos G, Nordling J, Sanz CR, Emberton M, de la Rosette JJ. EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). EurUrol 2004; 46:547–54.
[5] Lee C, Kozlowski JM, Grayhack JT. Etiology of benign prostatic hyperplasia. UrolClin North Am 1995; 22:237–46.
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[7] Hammarsten J, Hogstedt B. Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. EurUrol 2001; 39:151–8.
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[19] Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Chamber Quantification Writing Group; American Society of Echocardiography’s Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: A report from the American Society of Echocardiography’s Guidelines and Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am SocEchocardiogr. 2005; 18:1440-1463.
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Author Information
  • Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Surgery, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Radiology, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Surgery, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Family Medicine, Ekiti State University Teaching Hospital, Ado Ekiti, Nigeria

  • Department of Medicine, Ekiti State University, Ado Ekiti, Nigeria

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    Ebenezer Adekunle Ajayi, Patrick Temi Adegun, Ganiyu Olusola Akanbi, Akande Oladimeji Ajayi, Peter Olufemi Areo, et al. (2017). Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study. Clinical Medicine Research, 6(4), 121-126. https://doi.org/10.11648/j.cmr.20170604.11

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    ACS Style

    Ebenezer Adekunle Ajayi; Patrick Temi Adegun; Ganiyu Olusola Akanbi; Akande Oladimeji Ajayi; Peter Olufemi Areo, et al. Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study. Clin. Med. Res. 2017, 6(4), 121-126. doi: 10.11648/j.cmr.20170604.11

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    AMA Style

    Ebenezer Adekunle Ajayi, Patrick Temi Adegun, Ganiyu Olusola Akanbi, Akande Oladimeji Ajayi, Peter Olufemi Areo, et al. Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study. Clin Med Res. 2017;6(4):121-126. doi: 10.11648/j.cmr.20170604.11

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  • @article{10.11648/j.cmr.20170604.11,
      author = {Ebenezer Adekunle Ajayi and Patrick Temi Adegun and Ganiyu Olusola Akanbi and Akande Oladimeji Ajayi and Peter Olufemi Areo and Felix Olukayode Aina and Samuel Ayokunle Dada},
      title = {Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study},
      journal = {Clinical Medicine Research},
      volume = {6},
      number = {4},
      pages = {121-126},
      doi = {10.11648/j.cmr.20170604.11},
      url = {https://doi.org/10.11648/j.cmr.20170604.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cmr.20170604.11},
      abstract = {Ageing in men is associated with increased prevalence of cardiovascular risk factors and benign prostatic hyperplasia (BPH) with both entities possibly representing downstream manifestations of a common pathogenesis. There is paucity of data on the association of BPH and left ventricular hypertrophy (LVH). This study evaluated relationship between prostate volume, common cardiovascular risk factors and LVH. It was a cross sectional, prospective, hospital-based study. Thirty patients with benign prostatic enlargement (BPE) and 30 age- matched male controls without BPE were studied. All the subjects had clinical, biochemical, prostate ultrasound and echocardiographic evaluation done. SPSS IBM 20 was used to analyze data. Mean age was 65.60 ± 8.11 years (range: 54-82years). Subjects with BPE compared to those without did not significantly differ in age (66.50± 7.75 vs. 64.70±8.49; p=0.39). Significantly higher percentage of subjects with BPE had abnormally low HDL-cholesterol and high blood pressure compared with subjects without BPE. Eight (26.7%) of subjects with BPE in contrast to none of the subjects without BPE had metabolic syndrome (Chi2 = 9.231; p=0.002). Left ventricular mass index were significantly higher in subjects with BPE than in those without. None of the subjects without BPE as compared with 7 (23.3%) of subjects with BPE had echocardiographic determined LVH. Echocardiographic indices that significantly correlated with prostatic volume were: LVPWd (r=0.326, p= 0.011), IVSTd (r= 0.267, p=0.039), LVMI(r=0.308, p= 0.017), LAD (r= 0.494, p <0.0001) and AOD (r= 0.352, p= 0.006). The conclusion was that BPE is associated with increased left ventricular mass index and metabolic syndrome, mostly driven by elevated blood pressure and low serum HDL-cholesterol.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study
    AU  - Ebenezer Adekunle Ajayi
    AU  - Patrick Temi Adegun
    AU  - Ganiyu Olusola Akanbi
    AU  - Akande Oladimeji Ajayi
    AU  - Peter Olufemi Areo
    AU  - Felix Olukayode Aina
    AU  - Samuel Ayokunle Dada
    Y1  - 2017/06/01
    PY  - 2017
    N1  - https://doi.org/10.11648/j.cmr.20170604.11
    DO  - 10.11648/j.cmr.20170604.11
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 121
    EP  - 126
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20170604.11
    AB  - Ageing in men is associated with increased prevalence of cardiovascular risk factors and benign prostatic hyperplasia (BPH) with both entities possibly representing downstream manifestations of a common pathogenesis. There is paucity of data on the association of BPH and left ventricular hypertrophy (LVH). This study evaluated relationship between prostate volume, common cardiovascular risk factors and LVH. It was a cross sectional, prospective, hospital-based study. Thirty patients with benign prostatic enlargement (BPE) and 30 age- matched male controls without BPE were studied. All the subjects had clinical, biochemical, prostate ultrasound and echocardiographic evaluation done. SPSS IBM 20 was used to analyze data. Mean age was 65.60 ± 8.11 years (range: 54-82years). Subjects with BPE compared to those without did not significantly differ in age (66.50± 7.75 vs. 64.70±8.49; p=0.39). Significantly higher percentage of subjects with BPE had abnormally low HDL-cholesterol and high blood pressure compared with subjects without BPE. Eight (26.7%) of subjects with BPE in contrast to none of the subjects without BPE had metabolic syndrome (Chi2 = 9.231; p=0.002). Left ventricular mass index were significantly higher in subjects with BPE than in those without. None of the subjects without BPE as compared with 7 (23.3%) of subjects with BPE had echocardiographic determined LVH. Echocardiographic indices that significantly correlated with prostatic volume were: LVPWd (r=0.326, p= 0.011), IVSTd (r= 0.267, p=0.039), LVMI(r=0.308, p= 0.017), LAD (r= 0.494, p <0.0001) and AOD (r= 0.352, p= 0.006). The conclusion was that BPE is associated with increased left ventricular mass index and metabolic syndrome, mostly driven by elevated blood pressure and low serum HDL-cholesterol.
    VL  - 6
    IS  - 4
    ER  - 

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