Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin
American Journal of Nursing Science
Volume 7, Issue 3-1, June 2018, Pages: 77-85
Received: Dec. 4, 2017; Accepted: Dec. 6, 2017; Published: Dec. 25, 2017
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Andriana Theodorakopoulou, Hemodynamic Laboratory, Hippokration General Hospital, Athens, Greece
Maria Kapella, Director of Nursing, Hippokration General Hospital, Athens, Greece
Vasiliki Kontou, Department of Nursing Specialities, Hippokration General Hospital, Athens, Greece
Sofia Giovaso, Hemodynamic Laboratory, Onassis Cardiac Surgery Center, Athens, Greece
Theodoros Katsaras, Psychiatric Department, Sotiria Hospital, Athens, Greece
Spilios Manolakopoulos, 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece
Dimitris Pectasidis, 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece
John Koskinas, 2nd Department of Medicine, Medical School of Athens, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece
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Introduction: Chronic hepatitis C is a serious public health problem worldwide. Approximately eighty percent of the patients with acute infection will fall back to chronicity with long term complications such as cirrhosis, liver failure, hepatocellular cancer and death. The HCV infection per se has been found to be related with a variety of neuropsychiatric symptoms. Treatment of hepatitis C with interferon plus ribavirin is related with many side effects and affects the quality of patients’ life. Purpose: The purpose of this study is to assess the quality of life in patients with chronic hepatitis C undergoing treatment with interferon and Ribavirin. Data and Methodology: The research sample was 173 patients with hepatitis C who were treated in the Outpatient Liver Unit, 2nd Department of Internal Medicine, Medical School of Athens, Hippokratio General Hospital". The data were hand- collected after the Short Form 36 scale completion by the patients. For the data analysis the statistical package SPSS 13 was used and more specifically statistical t-test and anova analysis. Results: Out of all the patients participated in the study the 28.9% were women and 71.1% were men with an average age of 54.4 years with a standard deviation of 8.14 years. The 87.3% had concomitant diseases; 88.4% diabetes, 56.6% hypertension and 59.5% high cholesterol. 38.15% of the sample had re-admitted to the hospital, 18.40% had previous heart attack and 63.16% were former smokers. The statistical analysis indicated those who had a higher education degree peported higher quality of life sores in the dimensions of mental health (p=0.001), physical function (p=0.01) and vitality (p=0.000). Similar, married patients reported higher quality of life scoers in several dimension as well as patients without readmissions, patients without comorbidities and non-smokers. Conclusions: treatment with interferon and Ribavirin affects the quality of life of patients with chronic hepatitis C. Factors such as age, lifestyle, educational level, the reintroduction in the hospital and marital status can affect the life and mental health of the patient. The factors that adversely affect the quality of life must be identified and treated promptly by health professionals
Quality of Life, Hepatitis C, Treatment, Interferon, Ribavirin
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Andriana Theodorakopoulou, Maria Kapella, Vasiliki Kontou, Sofia Giovaso, Theodoros Katsaras, Spilios Manolakopoulos, Dimitris Pectasidis, John Koskinas, Quality of Life in Patients with Chronic Hepatitis C Submitted to Treatment with Interferon and Ribavirin, American Journal of Nursing Science. Special Issue:Nursing Education and Research. Vol. 7, No. 3-1, 2018, pp. 77-85. doi: 10.11648/j.ajns.s.2018070301.22
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