Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents
International Journal of Nutrition and Food Sciences
Volume 4, Issue 2-1, March 2015, Pages: 21-25
Received: Dec. 20, 2014; Accepted: Jan. 25, 2015; Published: Mar. 2, 2015
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Authors
Farzaneh Bagherzadeh, Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Mehrangiz Ebrahimi-Mameghani, Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Asghari Jafarabadi, Medical Education Research Center, Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
Zahra Aslani, Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sare Edalati, Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
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Abstract
Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.
Keywords
Oxidative Stress, Oxidative DNA Damage, Adolescents, Body Mass Index, Age, Sex
To cite this article
Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati, Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents, International Journal of Nutrition and Food Sciences. Special Issue:Functional Foods and Nutraceuticals for Management of Type 2 Diabetes. Vol. 4, No. 2-1, 2015, pp. 21-25. doi: 10.11648/j.ajbio.s.2015030202.11
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