Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats
International Journal of Nutrition and Food Sciences
Volume 2, Issue 2, March 2013, Pages: 24-30
Received: Feb. 1, 2013;
Published: Mar. 10, 2013
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Mostafa M. Osfor, Clinical Nutrition Department, Applied Medical Sciences College, Umm Al-Qura University, Makkah, Saudi Arabia
Osama Kensarah, Clinical Nutrition Department, Applied Medical Sciences College, Umm Al-Qura University, Makkah, Saudi Arabia
Firas Azzeh, Clinical Nutrition Department, Applied Medical Sciences College, Umm Al-Qura University, Makkah, Saudi Arabia
Mohammad A. Elmadbouly, Clinical Nutrition Department, Applied Medical Sciences College, Umm Al-Qura University, Makkah, Saudi Arabia
Mona El-Qutry, Nutrition and Food science, Home Economic Collage, Ain Shame University, Cairo, Egypt
The effect of high fat diet on lipid and carbohydrate metabolic changes was studied in mature male albino rats. The animals were rendered obese by feeding a high fat diet for 60 days. Half of obese rats were become diabetic by injecting with a reduced dose of alloxan; to produce a non insulin dependent diabetes mellitus state. These obese models of non diabetic and diabetic rats were compared with normal male rats kept on a basal diet for 60 days. The fat fed rats beside gaining weight showed a significant rise in their hepatic lipid contents and observed an insulin resistant state. Lipid profile of the omental adipose tissue exhibited a significantly higher total lipid content, but lower total cholesterol, triglycerides and phospholipids contents in both obese (non diabetic and diabetic) as compared with the normal rats. On the other hand, the brown adipose tissue showed a reduced fat catabolism with a significant rise in its phospholipid contents. Correlation between plasma atherogenic index and plasma fatty acids pattern showed that in the obese diabetic rats atherogenic index was positively correlated with total polyunsaturated fatty acids, while significantly negative correlation with total saturated fatty acids. This work showed that high fat substrates have been got remarkable impacts on rats body weight and metabolism.
Mostafa M. Osfor,
Mohammad A. Elmadbouly,
Biochemical Changes in LIPID and Car-bohydrate Metabolism in Obese Diabetic Male Albino Rats, International Journal of Nutrition and Food Sciences.
Vol. 2, No. 2,
2013, pp. 24-30.
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