Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals
International Journal of Nutrition and Food Sciences
Volume 2, Issue 6, November 2013, Pages: 266-271
Received: Aug. 22, 2013; Published: Oct. 20, 2013
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Authors
Maddala Rajeswari, Department of Foods, Nutrition and Dietetics, College of Home Science, University of Mumbai, Mumbai, India
Subbulakshmi Gurumurthy, Department of Foods, Nutrition and Dietetics, College of Home Science, University of Mumbai, Mumbai, India
Sandhya Kamat, Department of Pharmacology, GS Seth Medical College and KEM Hospital, Mumbai, India
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Abstract
Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.
Keywords
Solanum Nigrum, Gastritis, Gastric Contents, Glandular Tissue, Gastric Ulcers, Pyloric Ligation, Ulcer Index
To cite this article
Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat, Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals, International Journal of Nutrition and Food Sciences. Vol. 2, No. 6, 2013, pp. 266-271. doi: 10.11648/j.ijnfs.20130206.11
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