International Journal of Nutrition and Food Sciences
Volume 5, Issue 6, November 2016, Pages: 372-377
Received: Sep. 16, 2016;
Accepted: Sep. 26, 2016;
Published: Oct. 17, 2016
Views 3452 Downloads 104
Aissouda Hossein zade, Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Maryam Moogooei, Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Shayan Mostafaei, Department of Biostatistics, Tarbiat Modares University, Tehran, Iran
Hossein Rahavi, Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Reza Mansouri, Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Sepideh Soukhtezari, Department of Medical Biotechnology, Tarbiat Modares Univesity, Tehran, Iran
Mojgan Ghaedi, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).
Aissouda Hossein zade,
Fatty Acids Effect on T Helper Differentiation in Vitro, International Journal of Nutrition and Food Sciences.
Vol. 5, No. 6,
2016, pp. 372-377.
Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity. 2013;38 (4):644-54.
Araki K, Ellebedy AH, Ahmed R. TOR in the immune system. Current opinion in cell biology. 2011;23 (6):707-15.
Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity. 2009;30 (5):656-65.
Hua J, Ma X, Webb T, Potter JJ, Oelke M, Li Z. Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. Journal of lipid research. 2010;51 (7):1696-703.
Monk JM, Hou TY, Turk HF, Weeks B, Wu C, McMurray DN, et al. Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. 2012.
Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of “Western diet” in inflammatory autoimmune diseases. Current allergy and asthma reports. 2014;14 (1):1-8.
White JH. Vitamin D metabolism and signaling in the immune system. Reviews in Endocrine and Metabolic Disorders. 2012;13 (1):21-9.
Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. The Journal of experimental medicine. 2007;204 (8):1765-74.
Monk JM, Jia Q, Callaway E, Weeks B, Alaniz RC, McMurray DN, et al. Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice. The Journal of nutrition. 2012;142 (1):117-24.
Woodworth HL, McCaskey SJ, Duriancik DM, Clinthorne JF, Langohr IM, Gardner EM, et al. Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. Cancer research. 2010;70 (20):7960-9.
Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. Journal of lipid research. 2013;54 (4):923-35.
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. nature. 2013;496 (7446):518-22.
Sinclair LV, Rolf J, Emslie E, Shi Y-B, Taylor PM, Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nature immunology. 2013;14 (5):500-8.
Gerriets VA, Rathmell JC. Metabolic pathways in T cell fate and function. Trends Immunol. 2012;33 (4):168-73.
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. The Journal of experimental medicine. 2011;208 (7):1367-76.
Powell JD, Delgoffe GM. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity. 2010;33 (3):301-11.
Ikejiri A, Nagai S, Goda N, Kurebayashi Y, Osada-Oka M, Takubo K, et al. Dynamic regulation of Th17 differentiation by oxygen concentrations. International immunology. 2011:dxr111.
Dang EV, Barbi J, Yang H-Y, Jinasena D, Yu H, Zheng Y, et al. Control of T H 17/T reg balance by hypoxia-inducible factor 1. Cell. 2011;146 (5):772-84.
Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 2010;28:445-89.
Kumar P, Natarajan K, Shanmugam N. High glucose driven expression of pro-inflammatory cytokine and chemokine genes in lymphocytes: molecular mechanisms of IL-17 family gene expression. Cellular signalling. 2014;26 (3):528-39.
Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. The Journal of Immunology. 2010;185 (6):3190-8.
Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T‐cell differentiation and function. Immunological reviews. 2012;249 (1):43-58.
Coomes SM, Pelly VS, Wilson MS. Plasticity within the αβ+ CD4+ T-cell lineage: when, how and what for? Open biology. 2013;3 (1):120157.
Rathmell JC. Metabolism and autophagy in the immune system: immunometabolism comes of age. Immunological reviews. 2012;249 (1):5-13.
Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. The Journal of Immunology. 2011;186 (6):3299-303.
Park J, Kim M, Kang S, Jannasch A, Cooper B, Patterson J, et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway. Mucosal immunology. 2015;8 (1):80-93.
Ajuwon KM, Spurlock ME. Palmitate activates the NF-κB transcription factor and induces IL-6 and TNFα expression in 3T3-L1 adipocytes. The Journal of nutrition. 2005;135 (8):1841-6.
Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, et al. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. The Journal of Immunology. 2014;193 (4):1666-71.
Sales-Campos H, Reis de Souza P, Crema Peghini B, Santana da Silva J, Ribeiro Cardoso C. An overview of the modulatory effects of oleic acid in health and disease. Mini reviews in medicinal chemistry. 2013;13 (2):201-10.
Carrillo Pérez C, Cavia Camarero MdM, Alonso de la Torre S. Role of oleic acid in immune system; mechanism of action; a review. Nutrición Hospitalaria, 2012, v 27, n 4 (julio-agosto), p 978-990. 2012.
Han S-C, Koo D-H, Kang N-J, Yoon W-J, Kang G-J, Kang H-K, et al. Docosahexaenoic Acid Alleviates Atopic Dermatitis by Generating Tregs and IL-10/TGF-β-Modified Macrophages via a TGF-β-Dependent Mechanism. Journal of Investigative Dermatology. 2015;135 (6):1556-64.
Datta G, Kramer PA, Johnson MS, Sawada H, Smythies LE, Crossman DK, et al. Bioenergetic programming of macrophages by the apolipoprotein AI mimetic peptide 4F. Biochemical Journal. 2015;467 (3):517-27.