Toxicological Effects of Sudan III Azo Dye in Palm Oil on Liver Enzyme and Non Enzyme Markers of Albino Rat
International Journal of Nutrition and Food Sciences
Volume 9, Issue 4, July 2020, Pages: 104-111
Received: Jun. 16, 2020; Accepted: Jul. 1, 2020; Published: Jul. 30, 2020
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Authors
Nwachoko Ndidi, Department of Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria
Odinga Tamuno-boma, Department of Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria
Akuru Udiomine Brantley, Department of Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria
Ibanibo Tamunomiebam Emmanuel, Department of Chemistry (Biochemistry Option), Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria
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Abstract
The economic and nutritional value of palm oil has made its utilization to be on the increase especially in Nigeria, thereby making it expensive, hence the temptation to adulterate it by bulk buyers with the wrong assertion of retaining the quality. This study was therefore undertaken to evaluate the effect of adulterated palm oil on the activity of liver enzymes and non-liver enzymes markers of albino rats. Twenty rats divided into five groups of four rats each were used for this investigation for fourteen (14) days. At the end of the experiment, the animals were sacrificed, blood samples were collected for biochemical analysis. Biochemical indices of liver enzymes makers and non-liver markers were determined. Liver enzymes ALP and ALT concentrations showed significant increase (p<0.05) when compared with group 1 and 2, also non-liver markers albumin, conjugated and total bilirubin showed significant increase (p<0.05) when compared to group 1 and 2. Histopathological examination showed mild inflammation of the liver for group 3, while histological features for groups (4 & 5) administered with higher dosage showed intense periportal and intraparenchymal inflammations. A compromise in liver function in rats administered with adulterated palm oil was observed.
Keywords
Sudan III Dye, Palm Oil, Bilirubin, Albumin, Liver Function Biomarkers
To cite this article
Nwachoko Ndidi, Odinga Tamuno-boma, Akuru Udiomine Brantley, Ibanibo Tamunomiebam Emmanuel, Toxicological Effects of Sudan III Azo Dye in Palm Oil on Liver Enzyme and Non Enzyme Markers of Albino Rat, International Journal of Nutrition and Food Sciences. Vol. 9, No. 4, 2020, pp. 104-111. doi: 10.11648/j.ijnfs.20200904.12
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Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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