A Sesame Seeds-Based Breakfast Could Attenuate Sub-Clinical Inflammation in Type 2 Diabetic Patients: A Randomized Controlled Trial
International Journal of Nutrition and Food Sciences
Volume 4, Issue 2-1, March 2015, Pages: 1-5
Received: Sep. 8, 2014;
Accepted: Sep. 15, 2014;
Published: Sep. 20, 2014
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Zahra Bahadoran, Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parvin Mirmiran, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Somayeh Hosseinpour-Niazi, Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fereidoun Azizi, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background and aim: The aim of this study was to investigate the effects of Tahini, a traditional functional food made from ground un-hulled sesame seeds, on glucose homeostasis parameters and serum high-sensitive reactive protein (hs-CRP) in diabetic patients. Methods: This randomized clinical trial included 41 patients with type 2 diabetes, who were randomly assigned to one of two groups: Group A (Tahini 30 g/d, n=21) and group B (control, n=20). After an initial 2-week washout period, patients in group A, replaced a part of their usual breakfast with 2 tbsp (~28 g) Tahini, while group B patients continued the usual breakfast meal for 6 weeks. Insulin and hs-CRP levels were measured, and insulin sensitivity index and homeostasis model assessment of insulin resistance index (HOMA-IR) at were calculated baseline and 6 weeks intervention. Results: After 6-weeks, there was a significant 21.1% decrease in serum hs-CRP levels in group A. Slight but non-significant decrease in fasting serum glucose, serum insulin, insulin sensitivity index and HOMA-IR was observed during Tahini supplementation. Conclusion: Replacing a part of regular diet with Tahini as a functional food could attenuate sub-clinical inflammation in type 2 diabetic patients.
A Sesame Seeds-Based Breakfast Could Attenuate Sub-Clinical Inflammation in Type 2 Diabetic Patients: A Randomized Controlled Trial, International Journal of Nutrition and Food Sciences. Special Issue: Functional Foods and Nutraceuticals for Management of Type 2 Diabetes.
Vol. 4, No. 2-1,
2015, pp. 1-5.
Ndumele CE, Pradhan AD, Ridker PM. (2006). Interrelationships between inflammation, C-reactive protein, and insulin resistance. Journal of the Cardiometabolic Syndrome 1:190-6.
Ridker PM. (2004). High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit. American Heart Journal 148(1 Suppl):S19-26.
Nyström T. (2007). C-reactive protein: a marker or a player? Clinical Science (Lond) 113:79-81.
Castoldi G, Galimberti S, Riva C, Papagna R, Querci F, Casati M, Zerbini G, Caccianiga G, Ferrarese C, Baldoni M, Valsecchi MG, Stella A. (2007). Association between serum values of C-reactive protein and cytokine production in whole blood of patients with type 2 diabetes. Clinical Science (Lond) 113:103-8.
Sarangi R, Padhi S, Mohapatra S, Swain S, Padhy RK, Mandal MK, Patro SK, Kumar S. (2012). Serum high sensitivity C-reactive protein, nitric oxide metabolites, plasma fibrinogen, and lipid parameters in Indian type 2 diabetic males. Diabetes and Metabolic Syndrome 6:9-14.
Roopakala MS, Pawan HR, Krishnamurthy U, Wilma Delphine Silvia CR, Eshwarappa M, Prasanna Kumar KM. (2012). Evaluation of high sensitivity C-reactive protein and glycated hemoglobin levels in diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation 23:286-9.
Martinchik AN. (2011). Nutritional value of sesame seeds. Vopr Pitan 80:41-3.
Namiki M.(2007). Nutraceutical functions of sesame: a review. Critical Reviews in Food Science and Nutrition 47:651-73.
Elleuch M, Besbes S, Roiseux O, Blecker C, Attia H. (2007). Quality characteristics of sesame seeds and by-products. Food Chemistry 103:641-50.
Kamal-Eldin A, Moazzami A, Washi S. (2011). Sesame seed lignans: potent physiological modulators and possible ingredients in functional foods & nutraceuticals. Recent Patents on Food, Nutrition & Agriculture 3:17-29.
Hsu DZ, Chen KT, Chu PY, Li YH, Liu MY. (2007). Sesame oil protects against leadplus- lipopolysaccharide-induced acute hepatic injury. Shock 27:334–337.
Hsu DZ, Su SB, Chien SP, Chiang PJ, Li YH, Lo YJ, Liu MY. (2005). Effect of sesame oil on oxidativestress- associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines. Shock 24:276–280.
Wu JH, Hodgson JM, Puddey IB, Belski R, Burke V, Croft KD. (2009). Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutrition, Metabolism and Cardiovascular Disease 19:774-8.
Karatzi K, Stamatelopoulos K, Lykka M, Mantzouratou P, Skalidi S, Manios E, Georgiopoulos G, Zakopoulos N, Papamichael C, Sidossis LS. (2012). Acute and long-term hemodynamic effects of sesame oil consumption in hypertensive men. Journal of Clinical Hypertension (Greenwich) 14:630-6.
Schulz KF, Altman DG, Moher. (2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Journal of Clinical Epidemiology 63:834-40.
Silfen ME, Mavibo AM, McMahon, Levine LS, Murphy AR, Oberfield SE. (2001). Fasting glucose to insulin ratio is a simple and useful measure of insulin resistance in young girls. The Journal of Clinical Endocrinology & Metabolism 86:2863-8.
Hanley AJ, Stern MP, Williams K, Haffner SM. (2002). Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease. Diabetes care 25:1177-84.
Jeng KC, Hou RC, Wang JC, Ping LI. (2005). Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB. Immunology Letters 97:101-6.
Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP. (2001). Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50:2792-808.
Trattner S, Ruyter B, Østbye TK, Gjøen T, Zlabek V, Kamal-Eldin A, Pickova J. (2008). Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. Lipids 43:999-1008.
Du Y, Tang J, Li G, Berti-Mattera L, Lee CA, Bartkowski D, Gale D, Monahan J, Niesman MR, Alton G, Kern TS. (2005). Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Immunology Letters 97:101-6.
Ohshima K, Mogi M, Horiuchi M. (2012). Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation. International Journal of Vascular Medicine 2012:508416.
Siqueira A, João FM. (2008). Effect of defatted sesame (Sesamum indicum L.) flour on the blood glucose level in type 2 diabetic women. Revista brasileira de farmacognosia 18:77-83.
Sankar D, Rao MR, Sambandam G, Pugalendi KV. (2006). Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status. Yale Journal of Biology and Medicine 79:19-26.
Ramesh B, Saravanan R, Pugalendi KV. (2005). Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. Journal of Medicinal Food 8: 377-81.