Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents

Farzaneh Bagherzadeh; Mehrangiz Ebrahimi-Mameghani; Mohammad Asghari Jafarabadi; Zahra Aslani; Sare Edalati

doi:doi:10.11648/j.ajbio.s.2015030202.11

| Peer-Reviewed

Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents

Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati

Published in International Journal of Nutrition and Food Sciences (Volume 4, Issue 2-1)

Received: 20 December 2014 Accepted: 25 January 2015 Published: 2 March 2015

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.

Published in	International Journal of Nutrition and Food Sciences (Volume 4, Issue 2-1) This article belongs to the Special Issue Functional Foods and Nutraceuticals for Management of Type 2 Diabetes
DOI	10.11648/j.ajbio.s.2015030202.11
Page(s)	21-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Oxidative Stress, Oxidative DNA Damage, Adolescents, Body Mass Index, Age, Sex

References

[1]	Rahman I, Kelly F. Review Biomarkers in Breath Condensate: A promising New Non-invasive Technique in Free Radical Research. FRA. 2003;37(12):1253-66.
[2]	Offord E, Van Poppel G, Tyrrell R. Markers of oxidative damage and antioxidant protection: current status and relevance to disease. FRA. 2000;33:S5.
[3]	Nemeth I, Boda D. Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome. JIC. 2001;27(1):21-26.
[4]	Tsukahara H, Sekine K, Uchiyama M, Kawakami H, Hata I, Todoroki Y, et al. Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes. Pediatr. Res.. 2003;54(3):419-24.
[5]	Kaneko K, Taniguchi N, Tanabe Y, Nakano T, Hasui M, Nozu K. Oxidative imbalance in idiopathic renal hypouricemia. Pediatr Neph. 2009;24(4):869-71.
[6]	Tung EW, Winn LM. Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. Mol. Pharmacol.. 2011;80(6):979-87.
[7]	Granot E, Kohen R. Oxidative stress in childhood-in health and disease states. Clin Nutr. 2004;23:3-11.
[8]	Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, et al. Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45. 1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Laboratory investigation; Lab Invest. 1997;76(3):365-74.
[9]	Jang-Young K, Jun-Won L, YounMin-Soo A, Sung-Gyun A. Urinary Levels of 8-Iso-Prostaglandin F2α and 8-Hydroxydeoxyguanine as Markers of Oxidative Stress in PatientsWith Coronary Artery Disease. Korean Circ J. 2012;42:614-7.
[10]	Valavanidis A, Vlachogianni T, Fiotakis C, C JESH. 8-Hydroxy-2′-deoxyguanosine (8-OHdG): acritical biomarker of oxidative stress and carcinogenesis. 2009;27:120-39.
[11]	Wu LL, Chiou C-C, Chang P-Y, Wu JT. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clinica Chimica Acta. 2004;339(1):1-9.
[12]	Subash P, Gurumurthy P, Sarasabharathi A, Cherian K. Urinary 8-OHdG: a marker of oxidative stress to dna and total antioxidant status in essential hypertension with South Indian population. IJCB. 2010;25(2):127-32.
[13]	Hwang E-S, Kim G-H. RETRACTED: Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology. 2007;229(1):1-10.
[14]	Sakano N, Wang D-H, Takahashi N, Wang B, Sauriasari R, Kanbara S, et al. Oxidative stress biomarkers and lifestyles in Japanese healthy people. JCBN2009;44(2):185.
[15]	Halliwell B. Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am Clin Nutr. 2000;72(5):1082-7.
[16]	Drury JA, Jeffers G, Cooke RW. Urinary 8-hydroxydeoxyguanosine in infants and children. FRA. 1998; 28(4): 423-8.
[17]	Kaneko K, Kimata T, Tsuji S, Ohashi A, Imai Y, Sudo H, et al. Measurement of urinary 8-oxo-7,8-dihydro-2-deoxyguanosine in a novel point-of-care testing device to assess oxidative stress in children. Clinica Chimica Acta. 2012;413:1822-6.
[18]	Tamura S, Tsukahara H, Ueno M. Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. FreeRadic Res. 2006;40:1198-205.
[19]	Tsukahara H. Biomarkers for oxidative stress: clinical application in pediatric medicine. Curr Med Chem. 2007; 14:339-51.
[20]	Piconi L, Quagliaro L, Ceriello A. Oxidative stress in diabetes. Clinical chemistry and laborator Med. 2003;41(9):1144-9.
[21]	Kasai H, Kawai K, Li Y-s. Analysis of 8-OH-dG and 8-OH-Gua as biomarkers of oxidative stress. Genes and Environment. 2008;30(2):33-40.
[22]	Tamura S, Tsukahara H, Ueno M, Maeda M, Kawakami H, Sekine K, et al. Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults. FRA. 2006;40(11):1198-205.
[23]	Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. MSSE. 2000;32(9; SUPP/1):S498-S504.
[24]	Poulsen HE, Loft S, Prieme H, Vistisen K, Lykkesfeldt J, Nyyssonen K, et al. Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion. FRA. 1998;29(6):565-71.
[25]	Chiavaroli V, Giannini C, De Marco S, Chiarelli F, Mohn A. Unbalanced oxidant–antioxidant status and its effects in pediatric diseases. Redox Report. 2011;16(3):101-7.
[26]	Kauffman LD, Sokol RJ, Jones RH, Awad JA, Rewers MJ, Norris JM. Urinary F 2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus. FRB M. 2003;35(6):551-7.
[27]	Andreazza AC, Bordin DL, Salvador M. Thiobarbituric acid reactive substances, seric superoxide dismutase and catalase activities in healthy subjects. Clinica Chimica Acta. 2005; 362(1):192-4.
[28]	Miles MV, Horn PS, Tang PH, Morrison JA, Miles L, DeGrauw T, et al. Age-related changes in plasma coenzyme Q 10 concentrations and redox state in apparently healthy children and adults. Clinica Chimica Acta. 2004; 347(1):139-44.
[29]	Atabek ME, Vatansev H, Erkul I. Oxidative stress in childhood obesity. J PEM. 2004; 17(8): 1063-8.
[30]	Evans MD, Dizdaroglu M, Cooke MS. Oxidative DNA damage and disease: induction, repair and significance. Mutation Research/Reviews in Mutation Research. 2004; 567(1): 1-61.
[31]	Chiou C-C, Chang P-Y, Chan E-C, Wu T-L, Tsao K-C, Wu JT. Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers. Clinica Chimica Acta. 2003; 334(1):87-94.

Cite This Article

Plain Text BibTeX RIS

APA Style

Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati. (2015). Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. International Journal of Nutrition and Food Sciences, 4(2-1), 21-25. https://doi.org/10.11648/j.ajbio.s.2015030202.11

Copy | Download

ACS Style

Farzaneh Bagherzadeh; Mehrangiz Ebrahimi-Mameghani; Mohammad Asghari Jafarabadi; Zahra Aslani; Sare Edalati. Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. Int. J. Nutr. Food Sci. 2015, 4(2-1), 21-25. doi: 10.11648/j.ajbio.s.2015030202.11

Copy | Download

AMA Style

Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati. Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. Int J Nutr Food Sci. 2015;4(2-1):21-25. doi: 10.11648/j.ajbio.s.2015030202.11

Copy | Download

@article{10.11648/j.ajbio.s.2015030202.11,
  author = {Farzaneh Bagherzadeh and Mehrangiz Ebrahimi-Mameghani and Mohammad Asghari Jafarabadi and Zahra Aslani and Sare Edalati},
  title = {Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {4},
  number = {2-1},
  pages = {21-25},
  doi = {10.11648/j.ajbio.s.2015030202.11},
  url = {https://doi.org/10.11648/j.ajbio.s.2015030202.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030202.11},
  abstract = {Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents
AU  - Farzaneh Bagherzadeh
AU  - Mehrangiz Ebrahimi-Mameghani
AU  - Mohammad Asghari Jafarabadi
AU  - Zahra Aslani
AU  - Sare Edalati
Y1  - 2015/03/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbio.s.2015030202.11
DO  - 10.11648/j.ajbio.s.2015030202.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 21
EP  - 25
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ajbio.s.2015030202.11
AB  - Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.
VL  - 4
IS  - 2-1
ER  -

Copy | Download

Author Information

Farzaneh Bagherzadeh

Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Mehrangiz Ebrahimi-Mameghani

Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Asghari Jafarabadi

Medical Education Research Center, Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
Zahra Aslani

Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sare Edalati

Department of Nutrition in Society, Nutrition Faculty, Tabriz University of Medical Sciences, Tabriz, Iran

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati. (2015). Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. International Journal of Nutrition and Food Sciences, 4(2-1), 21-25. https://doi.org/10.11648/j.ajbio.s.2015030202.11

Copy | Download

ACS Style

Farzaneh Bagherzadeh; Mehrangiz Ebrahimi-Mameghani; Mohammad Asghari Jafarabadi; Zahra Aslani; Sare Edalati. Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. Int. J. Nutr. Food Sci. 2015, 4(2-1), 21-25. doi: 10.11648/j.ajbio.s.2015030202.11

Copy | Download

AMA Style

Farzaneh Bagherzadeh, Mehrangiz Ebrahimi-Mameghani, Mohammad Asghari Jafarabadi, Zahra Aslani, Sare Edalati. Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents. Int J Nutr Food Sci. 2015;4(2-1):21-25. doi: 10.11648/j.ajbio.s.2015030202.11

Copy | Download

@article{10.11648/j.ajbio.s.2015030202.11,
  author = {Farzaneh Bagherzadeh and Mehrangiz Ebrahimi-Mameghani and Mohammad Asghari Jafarabadi and Zahra Aslani and Sare Edalati},
  title = {Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {4},
  number = {2-1},
  pages = {21-25},
  doi = {10.11648/j.ajbio.s.2015030202.11},
  url = {https://doi.org/10.11648/j.ajbio.s.2015030202.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2015030202.11},
  abstract = {Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents
AU  - Farzaneh Bagherzadeh
AU  - Mehrangiz Ebrahimi-Mameghani
AU  - Mohammad Asghari Jafarabadi
AU  - Zahra Aslani
AU  - Sare Edalati
Y1  - 2015/03/02
PY  - 2015
N1  - https://doi.org/10.11648/j.ajbio.s.2015030202.11
DO  - 10.11648/j.ajbio.s.2015030202.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 21
EP  - 25
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ajbio.s.2015030202.11
AB  - Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.
VL  - 4
IS  - 2-1
ER  -

Copy | Download