Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals

Maddala Rajeswari; Subbulakshmi Gurumurthy; Sandhya Kamat

doi:doi:10.11648/j.ijnfs.20130206.11

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Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals

Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat

Received: 22 August 2013 Accepted: Published: 20 October 2013

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Abstract

Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.

DOI	10.11648/j.ijnfs.20130206.11
Published in	International Journal of Nutrition and Food Sciences (Volume 2, Issue 6, November 2013)
Page(s)	266-271
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Solanum Nigrum, Gastritis, Gastric Contents, Glandular Tissue, Gastric Ulcers, Pyloric Ligation, Ulcer Index

References

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APA Style

Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat. (2013). Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. International Journal of Nutrition and Food Sciences, 2(6), 266-271. https://doi.org/10.11648/j.ijnfs.20130206.11

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ACS Style

Maddala Rajeswari; Subbulakshmi Gurumurthy; Sandhya Kamat. Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. Int. J. Nutr. Food Sci. 2013, 2(6), 266-271. doi: 10.11648/j.ijnfs.20130206.11

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AMA Style

Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat. Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. Int J Nutr Food Sci. 2013;2(6):266-271. doi: 10.11648/j.ijnfs.20130206.11

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@article{10.11648/j.ijnfs.20130206.11,
  author = {Maddala Rajeswari and Subbulakshmi Gurumurthy and Sandhya Kamat},
  title = {Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {2},
  number = {6},
  pages = {266-271},
  doi = {10.11648/j.ijnfs.20130206.11},
  url = {https://doi.org/10.11648/j.ijnfs.20130206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130206.11},
  abstract = {Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.},
 year = {2013}
}

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TY  - JOUR
T1  - Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals
AU  - Maddala Rajeswari
AU  - Subbulakshmi Gurumurthy
AU  - Sandhya Kamat
Y1  - 2013/10/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ijnfs.20130206.11
DO  - 10.11648/j.ijnfs.20130206.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 266
EP  - 271
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20130206.11
AB  - Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.
VL  - 2
IS  - 6
ER  -

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Author Information

Maddala Rajeswari

Department of Foods, Nutrition and Dietetics, College of Home Science, University of Mumbai, Mumbai, India
Subbulakshmi Gurumurthy

Department of Foods, Nutrition and Dietetics, College of Home Science, University of Mumbai, Mumbai, India
Sandhya Kamat

Department of Pharmacology, GS Seth Medical College and KEM Hospital, Mumbai, India

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Plain Text BibTeX RIS

APA Style

Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat. (2013). Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. International Journal of Nutrition and Food Sciences, 2(6), 266-271. https://doi.org/10.11648/j.ijnfs.20130206.11

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ACS Style

Maddala Rajeswari; Subbulakshmi Gurumurthy; Sandhya Kamat. Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. Int. J. Nutr. Food Sci. 2013, 2(6), 266-271. doi: 10.11648/j.ijnfs.20130206.11

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AMA Style

Maddala Rajeswari, Subbulakshmi Gurumurthy, Sandhya Kamat. Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals. Int J Nutr Food Sci. 2013;2(6):266-271. doi: 10.11648/j.ijnfs.20130206.11

Copy | Download

@article{10.11648/j.ijnfs.20130206.11,
  author = {Maddala Rajeswari and Subbulakshmi Gurumurthy and Sandhya Kamat},
  title = {Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {2},
  number = {6},
  pages = {266-271},
  doi = {10.11648/j.ijnfs.20130206.11},
  url = {https://doi.org/10.11648/j.ijnfs.20130206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130206.11},
  abstract = {Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Anti Gastritic and Antiulcerogenic Effects of Solanum Nigrum in Laboratory Animals
AU  - Maddala Rajeswari
AU  - Subbulakshmi Gurumurthy
AU  - Sandhya Kamat
Y1  - 2013/10/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ijnfs.20130206.11
DO  - 10.11648/j.ijnfs.20130206.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 266
EP  - 271
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20130206.11
AB  - Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.
VL  - 2
IS  - 6
ER  -

Copy | Download