Studies on Chromium Picolinate Pre-Treated Albino Rats Given High Concentrations of Glucose D
Journal of Food and Nutrition Sciences
Volume 2, Issue 2, March 2014, Pages: 43-46
Received: Mar. 13, 2014;
Published: Mar. 30, 2014
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Mieebi Martin Wankasi, Department of Medical Laboratory Sciences, Faculty of Basic Medical Science, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria
Gborienemi Simeon George, Department of Medical Laboratory Sciences, Faculty of Basic Medical Science, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Bayelsa State, Nigeria
Ngozi Nwankwo, Department of Medical Laboratory Sciences, Faculty of Science, Rivers State University of Science and Technology, Nkpolu-oroworukwo, Port-Harcourt, Rivers State, Nigeria
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The status of chromium as an essential nutrient is an ongoing debate despite its widespread use as supplement. Chromium supplement has been reported to improve glucose tolerance, insulin action and promote weight loss. This study examined the effect of given high concentrations of glucose D to chromium picolinate pretreated rats. Male albino wistar rats (36) fed a standard diet for approximately 6 weeks, weighing (170-210g), were used for this study. After an overnight 12 hours fasting, the rats were divided into 2 groups (A and B). The Group A rats, further divided into 6 sub groups of three rats each, received oral glucose load of (0, 5, 10, 20 40 and 80 g/kg of body weight) respectively within 3 hours. While group B rats, were all pre-treated with 4µg/kg of chromium picolinate one hour prior to administration of concentrations of glucose D in similar manner as in group A, respectively. Plasma insulin, plasma and urine glucose measured after 24 hours, showed no statistical significant differences (P>0.05) in the mean plasma glucose, urine glucose, and plasma insulin levels between the groups. In conclusion, Chromium picolinate does not appear to improve insulin sensitivity and change plasma glucose level.
High Glucose concentration, Glucose Tolerance, Chromium Picolinate, Blood Glucose, Plasma Insulin
To cite this article
Mieebi Martin Wankasi,
Gborienemi Simeon George,
Studies on Chromium Picolinate Pre-Treated Albino Rats Given High Concentrations of Glucose D, Journal of Food and Nutrition Sciences.
Vol. 2, No. 2,
2014, pp. 43-46.
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