Hypervitaminia B12: An Unknown Endocrine Marker
Journal of Food and Nutrition Sciences
Volume 3, Issue 2, March 2015, Pages: 32-34
Received: Aug. 1, 2014; Accepted: Feb. 10, 2015; Published: Feb. 16, 2015
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Authors
Zulfiqar A. A., Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France
Sebaux A., Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France
Andrès E., Department of Internal Medicine, University of Strasbourg, Strasbourg, France
Novella J. L., Department of Internal Medicine and Geriatrics, University Hospital of Reims, Reims, France
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Abstract
Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy, renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.
Keywords
Hypervitaminia B12, Solid Neoplasms, Hemopathy, Renal Failure, Hepatic Disorders
To cite this article
Zulfiqar A. A., Sebaux A., Andrès E., Novella J. L., Hypervitaminia B12: An Unknown Endocrine Marker, Journal of Food and Nutrition Sciences. Vol. 3, No. 2, 2015, pp. 32-34. doi: 10.11648/j.jfns.20150302.11
References
[1]
Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr. 2011; 94(1):348S–358S.
[2]
Norredam K, Chainuvati T, Gimsing P, Hippe E, Viranuvatti V. Plasma cobalamin and transcobalamin in patients with primary carcinoma of the liver. A study from Thailand. Scand J Gastroenterol. 1983; 18(2):229–232.
[3]
Chiche L, Jean R, Romain F, et al. Clinical implications of high cobalamin blood levels for internal medicine. Rev Med Intern. 2008; 29(3):187–194.
[4]
Serraj K, Mecili M, Housni I, Andrès E. Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice. Presse Med. 2011;40(8):1120–1127.
[5]
Arendt JF, Nexo E. Cobalamin related parameters and disease patterns in patient’s with increased serum cobalamin levels. PLoS One. 2012; 7(9):e45979.
[6]
Arendt JF, Nexo E. Unexpected high plasma cobalamin: proposal for a diagnostic strategy. Clin Chem Lab Med. 2013; 51(3):489–496.
[7]
Johan Frederik Berg Arendt, Lars Pedersen, Ebba Nexo, Henrik Toft Sorensen. Elevated plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. JNCI 2013, Vol. 105, Issue 23 | December 4.
[8]
Morkbak AL, Poulsen SS, Nexo E. Haptocorrin in humans. Clin Chem Lab Med. 2007; 45(12):1751–1759.
[9]
Zittoun J, Zittoun R, Marquet J, Sultan C. The three transcobalamin in myeloproliferative disorders and acute leukaemia. Br J Haematol. 1975; 31(3):287– 298.
[10]
Wheeler K, Pritchard J, Luck W, Rossiter M.Transcobalamin I as a marker for fibrolamellar hepatoma. Med Pediatr Oncol. 1986; 14(2): 227-9.
[11]
Geissbühler P, Mermillod B, Rapin C-H. Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients: A Prospective Study Over Five Years. J Pain Symptom Manage. 2000; 20(2):93–103.
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