Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women
Journal of Food and Nutrition Sciences
Volume 6, Issue 1, January 2018, Pages: 1-11
Received: Aug. 10, 2017; Accepted: Sep. 9, 2017; Published: Dec. 14, 2017
Views 2160      Downloads 131
Authors
Erika Mizutani, Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan; Department of Food and Nutrition, College of Nagoya Bunri University, Nagoya, Japan
Sayuki Hashimoto, Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan; Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Japan
Hiromi Saito, Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Maiko Kato, Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Akihiro Yoshida, Department of Clinical Laboratory, Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan
Michitaka Naito, Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Article Tools
Follow on us
Abstract
Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−<25 kg/m2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.
Keywords
Sucrose, Fructose, Glucose, Triglyceride, Remnant Lipoprotein
To cite this article
Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito, Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women, Journal of Food and Nutrition Sciences. Vol. 6, No. 1, 2018, pp. 1-11. doi: 10.11648/j.jfns.20180601.11
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Carlson LA, Ericsson M. 1975. Quantitative and qualitative serum lipoprotein analysis. Part 1. Studies in healthy men and women. Atherosclerosis 21: 417-433.
[2]
Asia Pacific Cohort Studies Collaboration. 2004. Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region. Circulation 110: 2678-2686.
[3]
Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. 2007. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 298: 309-316.
[4]
Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. 2007. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298: 299-308.
[5]
Nordestgaard BG, Varbo A. 2014. Triglycerides and cardiovascular disease. Lancet 384: 626-35.
[6]
Varbo A, Benn M, Tybjaerg-Hansen A, Jorgensen AB, Frikke-Schmidt R, Nordestgaard BG. 2013. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol 61:427-36.
[7]
Welsh JA, Sharma A, Cunningham SA, Vos MB. 2011. Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation 123: 249-257.
[8]
Lee AK, Binongo JN, Chowdhury R, Stein AD, Gazmararian JA, Vos MB, Welsh JA. 2014. Consumption of less than 10% of total energy from added sugars is associated with increasing HDL in females during adolescence: a longitudinal analysis. J Am Heart Assoc 3: e000615.
[9]
Welsh JA, Sharma A, Abramson JL, Vaccarino V, Gillespie C, Vos MB. 2010. Caloric sweetener consumption and dyslipidemia among US adults. JAMA 303: 1490-1497.
[10]
Park YK, Yetley EA. 1993. Intakes and food sources of fructose in the United States. Am J Clin Nutr 58: 737S-747S.
[11]
Saito H, Kagaya M, Suzuki M, Yoshida A, Naito M. 2013. Simultaneous ingestion of fructose and fat exacerbates postprandial exogenous lipidemia in young healthy Japanese women. J Atheroscler Thromb 20: 591-600.
[12]
Saito H, Kato M, Yoshida A, Naito M. 2015. The ingestion of a fructose-containing beverage combined with fat cream exacerbates postprandial lipidemia in young healthy women. J Atheroscler Thromb 22: 85-94.
[13]
Nabeno Y, Fukuchi Y, Matsutani Y, Naito M. 2007. Influence of aging and menopause on postprandial lipoprotein responses in healthy adult women. J Atheroscler Thromb 14: 142-150.
[14]
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
[15]
Okada M, Saito T, Yoshimura H, Noguchi Y, Ito T, Sasaki H, Hama H. 2005. Surfactant-based homogeneous assay for the measurement of triglyceride concentrations in VLDL and intermediate-density lipoprotein. Clin Chem 51: 1804-1810.
[16]
Nakatani K, Sugimoto T, Masuda D, Okano R, Oya T, Monden Y, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Yuasa-Kawase M, Tsubakio-Yamamoto K, Ohama T, Nishida M, Ishigami M, Komuro I, Yamashita S. 2011. Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels. Atherosclerosis 218:226-232.
[17]
Sato I, Ishikawa Y, Ishimoto A, Katsura S, Toyokawa A, Hayashi F, Kawano S, Fujioka Y, Yamashita S, Kumagai S. 2009. Significance of measuring serum concentrations of remnant lipoproteins and apolipoprotein B-48 in fasting period. J Atheroscler Thromb 16: 12-20.
[18]
Frayn KN, Kingman SM. 1995. Dietary sugars and lipid metabolism in humans. Am J Clin Nutr 62: 250S-261S.
[19]
Riby JE, Fujisawa T, Kretchmer N. 1993. Fructose absorption. Am J Clin Nutr 58: 748S-753S.
[20]
Xiao C, Dash S, Morgantini C, Lewis GF. 2013. Novel role of enteral monosaccharides in intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol 33: 1056-1062.
[21]
Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Lê KA, Schneiter P, Bortolotti M, Frayn KN, Tappy L. 2010. Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr 104: 1139-1147.
[22]
Magkos F, Patterson BW, Mohammed BS, Klein S, Mittendorfer B. 2007. Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab. 92: 1311-1318.
[23]
Fisher RM, Coppack SW, Humphreys SM, Gibbons GF, Frayn KN. 1995. Human triacylglycerol-rich lipoprotein subfractions as substrates for lipoprotein lipase. Clin Chim Acta 236: 7-17.
[24]
Streja D, Kallai MA, Steiner G. 1977. The metabolic heterogeneity of human very low density lipoprotein triglyceride. Metabolism 26: 1333-1344.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186