Journal of Food and Nutrition Sciences

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Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women

Received: 10 August 2017    Accepted: 09 September 2017    Published: 14 December 2017
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Abstract

Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−<25 kg/m2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.

DOI 10.11648/j.jfns.20180601.11
Published in Journal of Food and Nutrition Sciences (Volume 6, Issue 1, January 2018)
Page(s) 1-11
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sucrose, Fructose, Glucose, Triglyceride, Remnant Lipoprotein

References
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[4] Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. 2007. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298: 299-308.
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[7] Welsh JA, Sharma A, Cunningham SA, Vos MB. 2011. Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation 123: 249-257.
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[16] Nakatani K, Sugimoto T, Masuda D, Okano R, Oya T, Monden Y, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Yuasa-Kawase M, Tsubakio-Yamamoto K, Ohama T, Nishida M, Ishigami M, Komuro I, Yamashita S. 2011. Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels. Atherosclerosis 218:226-232.
[17] Sato I, Ishikawa Y, Ishimoto A, Katsura S, Toyokawa A, Hayashi F, Kawano S, Fujioka Y, Yamashita S, Kumagai S. 2009. Significance of measuring serum concentrations of remnant lipoproteins and apolipoprotein B-48 in fasting period. J Atheroscler Thromb 16: 12-20.
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Author Information
  • Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan; Department of Food and Nutrition, College of Nagoya Bunri University, Nagoya, Japan

  • Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan; Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Japan

  • Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

  • Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

  • Department of Clinical Laboratory, Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan

  • Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

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    Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. (2017). Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. Journal of Food and Nutrition Sciences, 6(1), 1-11. https://doi.org/10.11648/j.jfns.20180601.11

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    ACS Style

    Erika Mizutani; Sayuki Hashimoto; Hiromi Saito; Maiko Kato; Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J. Food Nutr. Sci. 2017, 6(1), 1-11. doi: 10.11648/j.jfns.20180601.11

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    AMA Style

    Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J Food Nutr Sci. 2017;6(1):1-11. doi: 10.11648/j.jfns.20180601.11

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  • @article{10.11648/j.jfns.20180601.11,
      author = {Erika Mizutani and Sayuki Hashimoto and Hiromi Saito and Maiko Kato and Akihiro Yoshida and Michitaka Naito},
      title = {Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women},
      journal = {Journal of Food and Nutrition Sciences},
      volume = {6},
      number = {1},
      pages = {1-11},
      doi = {10.11648/j.jfns.20180601.11},
      url = {https://doi.org/10.11648/j.jfns.20180601.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jfns.20180601.11},
      abstract = {Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.},
     year = {2017}
    }
    

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    AU  - Erika Mizutani
    AU  - Sayuki Hashimoto
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    AU  - Maiko Kato
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    T2  - Journal of Food and Nutrition Sciences
    JF  - Journal of Food and Nutrition Sciences
    JO  - Journal of Food and Nutrition Sciences
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    PB  - Science Publishing Group
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    AB  - Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.
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