Using Date Seed Powder Nanoparticles and Infusion as a Sustainable Source of Nutraceuticals
Journal of Food and Nutrition Sciences
Volume 7, Issue 3, May 2019, Pages: 39-48
Received: Aug. 1, 2019;
Accepted: Aug. 22, 2019;
Published: Sep. 5, 2019
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Amany Alsayed Salama, Department of Nutrition, Faculty of Allied Medical Sciences, Pharos University in Alexandria, Alexandria, Egypt
Naglaa Mohamed Ismael, Department of Nutrition, Faculty of Allied Medical Sciences, Pharos University in Alexandria, Alexandria, Egypt
Mervat Mostafa Megeed, Department of Medical Devices, Faculty of Allied Medical Sciences, Pharos University in Alexandria, Alexandria, Egypt
Egypt is the world's largest date producing country. Different functional foods pertaining to date seeds were attempted before. Phenolic phytochemicals are not well absorbed in gastrointestinal tract, which results in lower bioactivity. Nanotechnology helps to resolve poor oral bioavailability. Aim was to evaluate the in-vivo anti-inflammatory properties of date seed powder (DSP) nanoparticles (NPs) and infusion in rats fed a high fat diet (HFD). Twenty five Wistar rats were distributed among five groups; I (control), II (on HFD), III (on HFD and DSPNP1 1:5), IV (on HFD and DSPNP2 2:3), and V (on HFD and DSP infusion 1g/kg/day). Blood samples were tested for C-reactive protein (CRP), Serum amyloid-A (SAA), total cholesterol, HDL, albumin, creatinine, and some primary biochemical parameters. HFD induced significant elevations in cholesterol and inflammatory markers as compared to the controls; while, HDL, ALT, AST, creatinine and albumin showed no change in all rats. In all DSP treatment groups, total cholesterol levels were reduced significantly. Both DSP NPs and infusion caused significant decrease in CRP and SAA levels. DSP NPs exhibited the same anti-inflammatory effects as their free counterparts. Using polyvinyl alcohol NPs of DSP in a wt/wt ratio of 2 PVA: 3 DSP; resulted in an acceptable particle size and physicochemical properties.
Amany Alsayed Salama,
Naglaa Mohamed Ismael,
Mervat Mostafa Megeed,
Using Date Seed Powder Nanoparticles and Infusion as a Sustainable Source of Nutraceuticals, Journal of Food and Nutrition Sciences.
Vol. 7, No. 3,
2019, pp. 39-48.
del Castillo MD, Iriondo-DeHond A, Martirosyan DM. Are Functional Foods Essential for Sustainable Health? Ann Nutr Food Sci. 2018; 2 (1): 1015.
Walker C, Gibney ER, Hellweg S. Comparison of environmental impact and nutritional quality among a European sample population – findings from the Food4Me study. Sci Rep. (2018) 8: 2330. doi: 10.1038/s41598-018-20391-4.
Varzakas T, Zakynthinos G, Verpoort F. Plant Food Residues as a Source of Nutraceuticals and Functional Foods. Foods. 2016; 5 (4): 88. doi: 10.3390/foods5040088.
Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. J Food Sci Technol. 2012 Apr; 49 (2): 173–183.
Kaiser Mahmood, Mohammed S. Alamri, Abdellatif Mohamed Abdellatif, Shahzad Hussain. Date pits (Phoenix dactylifera (L.)) waste to best. Agro Food Industry Hi Tech. 2015; 26 (3): 47-50.
FAOSTAT (2018) Food and Agriculture Organization of the United Nations. http://faostat.fao.org/. Accessed on 20-4- 2019.
Saryono S, Rahmawati E, Hapsari HE, Hidayat AI. Antioxidant enzyme status on rat after date seeds (Phoenix dactylifera) steeping treatment. Int J Res Med Sci. 2016; 4 (6): 1893-1896.
Saryono S et al. Anti-atherogenic properties of Deglet Noor Date seeds (Phoenix dactylifera) Methanol extract on Diet-Induced Hypercholesterolemic Rats. IOP Conf. Ser.: Mater. Sci. Eng. 2017; 172 012046. doi: 10.1088/1757-899X/172/1/012046.
Attanzio A, Tesoriere L, Poojary MM, Cilla A. Fruit and Vegetable Derived Waste as a Sustainable Alternative Source of Nutraceutical Compounds. Journal of Food Quality. 2018; 2018: 2 https://doi.org/10.1155/2018/8136190.
Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K. Inflammatory Links between High Fat Diets and Diseases. Frontiers in immunology. 2018; 9: 2649. doi: 10.3389/fimmu.2018.02649.
Forni C, Facchiano F, Bartoli M, et al. Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases. Biomed Res Int. 2019; 2019: 8748253. doi: 10.1155/2019/8748253.
Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho. Anti-inflammatory activity of natural dietary flavonoids. Food Funct. 2010; 1: 15-31 (doi: 10.1039/C0FO00103A).
Hossain KM, Abdal Dayem A, Han J, et al. Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids. Int J Mol Sci. 2016; 17 (4): 569.
Bilia AR, Isacchi B, Righeschi C, Guccione C, Bergonzi MC. Flavonoids Loaded in Nanocarriers: An Opportunity to Increase Oral Bioavailability and Bioefficacy. Food and Nutrition Sciences. 2014; 5: 1212-1227.
Li, Z., Jiang, H., Xu, C., and Gu, L. A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals. Food Hydrocolloids. 2015; 43: 153–164.
Roger, E., Lagarce, F., Garcion, E., and Benoit, J.‐P. Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery. Nanomedicine. 2010; 5: 287–306.
Ruiz, J. C. R., & Campos, M. R. S. (Eds.). (2016). New Polymers for Encapsulation of Nutraceutical Compounds. doi: 10.1002/9781119227625. Ch 4. Surface modifications that benefit protein‐based nanoparticles as vehicles for oral delivery of phenolic phytochemicals. Zheng Li.
Hatzor-de Picciotto A, Wissner-Gross AD, Lavallee G, Weiss PS. Experimental Nanoscience 2007; 2: 3-11.
Balzani V. Nanoscience and nanotechnology, Pure Appl. Chem. 2008; 80, 8: 1631-1650.
Serkov AT, Radishevskii MB. Nanotechnologies and chemical fibers. Fiber Chemistry 2008; 40: 32-36.
Muppalaneni S, Omidian H. Polyvinyl Alcohol in Medicine and Pharmacy: A Perspective. J Develop Drugs. 2013; 2: 112. doi: 10.4172/2329- 6631.1000112.
Türk CT, Bayindir ZS, Badilli U. Preparation of polymeric nanoparticles using different stabilizing agents. J. Fac. Pharm, Ankara. 2009; 38 (4): 257-268.
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research. PLoS Biol. 2010; 8 (6): e1000412.
Rahmani AH, Aly SM, Ali H, Babiker AY, Srikar S, Khan AA. Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity. Int J Clin Exp Med. 2014; 7 (3): 483-91.
Mohamed DA, Al-Okbi SY. In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. Pol J Food Nutr Sci. 2004; 13 (4): 397-402.
Al-Farsi MA, Lee CY. Nutritional and functional properties of dates: a review. Crit Rev Food Sci Nutr. 2008; 48 (10): 877-87. doi: 10.1080/10408390701724264.
Al-Farsi MA, Alasalvar C, Al-Abid M, Al-Shoaily K, Al-Amry M, Al-Rawahy F. Compositional and functional characteristics of dates, syrups, and their by-products. Food Chem. 2007; 104: 943–947.
Haleemkhan AA, Naseem, Vardhini BV. Synthesis of Nanoparticles from Plant Extracts. International Journal of Modern Chemistry and Applied Science. 2015; 2 (3): 195-203.
Awad MG., Al Olayan EM., Yehia HM., et al. Method of preparing date palm seed nanoparticles, King Saud University, US9623067B1US Grant, 2017.
Badawi JE, Mamdouh W. Nanoparticle formulation of Phoenix dactylifera L. (Ajwah and Black date) seed and peel and investigating their antioxidant and antibacterial properties [Master's Thesis] The American University in Cairo. 2018. http://dar.aucegypt.edu/bitstream/handle/10526/5600/final%20final%20for%20comittee.pdf?sequence=3.
Bagheri L., Madadlou A., Yarmand M., Mousavi M. E. Nano encapsulation of date palm pit extract in whey protein particles generated via desolvation method. Food Res. Int. 2013; 51: 866–871.
Keum CG, Noh YW, Baek JS, et al. Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid. Int J Nanomedicine. 2011; 6: 2225–2234. doi: 10.2147/IJN. S24547.
Magnuson A, Fouts J, Booth A, Foster M. Obesity-induced chronic low grade inflammation: Gastrointestinal and adipose tissue crosstalk. Integr Obesity Diabetes, 2015 Volume 1 (5): 103-108. doi: 10.15761/IOD.1000124.
Hursel R, Westerterp-Plantenga MS. Catechin- and caffeine-rich teas for control of body weight in humans. The American Journal of Clinical Nutrition. 2013; 98: 1682S–1693S.
Lu C, Zhu W, Shen C-L, Gao W. Green Tea Polyphenols Reduce Body Weight in Rats by Modulating Obesity-Related Genes. PLoS ONE. 2012; 7 (6): e38332. https://doi.org/10.1371/journal.pone.0038332.
Al-Rasheed, NM, Attia HA, Mohamad RA, Al-Rasheed NM, Al-Amin MA, AL-Onazi A. Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats. J. Evid. Based Complement. Altern. Med. 2015; 2015: 1-19. https://doi.org/10.1155/2015/247357.
Habib, H. M. and W. H. Ibrahim. Effect of date seeds on oxidative damage and antioxidant status in vivo. J. Sci. Food Agric. 2011; 91 (9): 1674-1679.
Saryono S, Rahmawati E, Hidayat AI, Hisni D, Proverawati A. Plasma Malondialdehyde and Vitamin E Levels after Date Palm Seeds (Phoenix dactylifera) Steeping Administration. Asian Journal of Clinical Nutrition. 2017; 9: 131-6.
Saryono S, Rahmawati E, Proverawati A, Hisni D. Effect of antioxidant status and oxidative stress products in pre-menopausal women after treatment with date seed powder (Phoenix dactylifera L.): A study on women in Indonesia. Pak J Nutr. 2017; 16 (6): 477-81. doi: 10.3923/ pjn.2017.477.481.
Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nature Immunology. 2015; 16 (5): 448-457.
Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006; 61 (6): 575–584. doi: 10.1093/gerona/61.6.575.
Johnson BD, Kip KE, Marroquin OS, Ridker PM, Kelsey SF, et al. Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation. 2004; 109: 726–732.
Huang Q, Yu H, Ru Q. Bioavailability and Delivery of Nutraceuticals Using Nanotechnology. JOURNAL OF FOOD SCIENCE. 2010; 75: R50-7.
Li Z, Percival SS, Bonard S, Gu L. Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects. Mol Nutr Food Res. 2011; 55 (7): 1096–1103.
Desai N. Challenges in Development of Nanoparticle-Based Therapeutics. The AAPS Journal. 2012; 14: 282-295.
Roger, E., Lagarce, F., Garcion, E. and Benoit, J.-P. Biopharmaceutical Parameters to Consider in Order to Alter the Fate of Nanocarriers after Oral Delivery. Nanomedicine. 2010; 5: 287-306. http://dx.doi.org/10.2217/nnm.09.110.
Georgieva J. V., Kalicharan D., Couraud P. et al., “Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro,” Molecular Therapy. 2011; 19: 318–325.
Cravatto G, Boffa L, Genzini L, Garella D. Phytotherapeutics: An evaluation of the potential of 1000 plants. J. Clin. Pharm. Ther. 2010; 35: 11-48.
Beg S, Swain S, Hasan H, Barkat MA, Hussain MS. Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacogn Rev. 2011; 5 (10): 120-37. doi: 10.4103/0973-7847.91102.