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The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
Journal of Food and Nutrition Sciences
Volume 8, Issue 5, September 2020, Pages: 127-138
Received: Oct. 7, 2020; Accepted: Oct. 22, 2020; Published: Oct. 30, 2020
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Authors
Huifeng Jin, Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Rolando Lorenzo Maddela, Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Robert Andrew Sinnott, Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
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Abstract
Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
Keywords
Cardio-Metabolic Risk Biomarkers, Oxidative Stress, Inflammation, MVMMs, Antioxidant Nutrients, NHANES, Multiple Regression
To cite this article
Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott, The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study, Journal of Food and Nutrition Sciences. Vol. 8, No. 5, 2020, pp. 127-138. doi: 10.11648/j.jfns.20200805.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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