The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott

doi:doi:10.11648/j.jfns.20200805.12

| Peer-Reviewed

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott

Published in Journal of Food and Nutrition Sciences (Volume 8, Issue 5)

Received: 7 October 2020 Accepted: 22 October 2020 Published: 30 October 2020

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Abstract

Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.

Published in	Journal of Food and Nutrition Sciences (Volume 8, Issue 5)
DOI	10.11648/j.jfns.20200805.12
Page(s)	127-138
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cardio-Metabolic Risk Biomarkers, Oxidative Stress, Inflammation, MVMMs, Antioxidant Nutrients, NHANES, Multiple Regression

References

[1]	Zimmet, P.; Alberti, K. G.; Shaw, J. Global and societal implications of the diabetes epidemic. Nature 2001, 414, 782-787, doi: 10.1038/414782a.
[2]	Reaven, G. M.; Chen, Y. D. Role of insulin in regulation of lipoprotein metabolism in diabetes. Diabetes Metab Rev 1988, 4, 639-652.
[3]	WHO: https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
[4]	Kelly, T.; Yang, W.; Chen, C. S.; Reynolds, K.; He, J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008, 32, 1431-1437, doi: 10.1038/ijo.2008.102.
[5]	Chobanian, A. V.; Bakris, G. L.; Black, H. R.; Cushman, W. C.; Green, L. A.; Izzo, J. L., Jr.; Jones, D. W.; Materson, B. J.; Oparil, S.; Wright, J. T., Jr., et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003, 42, 1206-1252, doi: 10.1161/01.HYP.0000107251.49515.c2.
[6]	Expert Panel on Detection, E.; Treatment of High Blood Cholesterol in, A. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001, 285, 2486-2497, doi: 10.1001/jama.285.19.2486.
[7]	Thompson, P. D.; Clarkson, P.; Karas, R. H. Statin-associated myopathy. JAMA 2003, 289, 1681-1690, doi: 10.1001/jama.289.13.1681.
[8]	Becker, D. J.; Gordon, R. Y.; Morris, P. B.; Yorko, J.; Gordon, Y. J.; Li, M.; Iqbal, N. Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial. Mayo Clin Proc 2008, 83, 758-764, doi: 10.4065/83.7.758.
[9]	Bronzato, S.; Durante, A. Dietary Supplements and Cardiovascular Diseases. International journal of preventive medicine 2018, 9, 80, doi: 10.4103/ijpvm.IJPVM_179_17.
[10]	Hill, A. M.; Fleming, J. A.; Kris-Etherton, P. M. The role of diet and nutritional supplements in preventing and treating cardiovascular disease. Current opinion in cardiology 2009, 24, 433-441, doi: 10.1097/HCO.0b013e32832f2fb1.
[11]	Kim, J.; Choi, J.; Kwon, S. Y.; McEvoy, J. W.; Blaha, M. J.; Blumenthal, R. S.; Guallar, E.; Zhao, D.; Michos, E. D. Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes 2018, 11, e004224, doi: 10.1161/CIRCOUTCOMES.117.004224.
[12]	Thompson, H. J.; Heimendinger, J.; Diker, A.; O'Neill, C.; Haegele, A.; Meinecke, B.; Wolfe, P.; Sedlacek, S.; Zhu, Z.; Jiang, W. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J Nutr 2006, 136, 2207-2212, doi: 10.1093/jn/136.8.2207.
[13]	Steyer, T. E.; King, D. E.; Mainous, A. G., 3rd; Gilbert, G. Use of nutritional supplements for the prevention and treatment of hypercholesterolemia. Nutrition 2003, 19, 415-418.
[14]	Rock, C. L. Multivitamin-multimineral supplements: who uses them? Am J Clin Nutr 2007, 85, 277S-279S, doi: 10.1093/ajcn/85.1.277S.
[15]	Bailey, R. L.; Gahche, J. J.; Miller, P. E.; Thomas, P. R.; Dwyer, J. T. Why US adults use dietary supplements. JAMA Intern Med 2013, 173, 355-361, doi: 10.1001/jamainternmed.2013.2299.
[16]	Ervin, R. B.; Wright, J. D.; Kennedy-Stephenson, J. Use of dietary supplements in the United States, 1988-94. Vital Health Stat 11 1999, i-iii, 1-14.
[17]	Fairfield, K. M.; Fletcher, R. H. Vitamins for chronic disease prevention in adults: scientific review. JAMA 2002, 287, 3116-3126, doi: 10.1001/jama.287.23.3116.
[18]	Blendon, R. J.; Benson, J. M.; Botta, M. D.; Weldon, K. J. Users' views of dietary supplements. JAMA Intern Med 2013, 173, 74-76, doi: 10.1001/2013.jamainternmed.311.
[19]	Sesso, H. D.; Christen, W. G.; Bubes, V.; Smith, J. P.; MacFadyen, J.; Schvartz, M.; Manson, J. E.; Glynn, R. J.; Buring, J. E.; Gaziano, J. M. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 2012, 308, 1751-1760, doi: 10.1001/jama.2012.14805.
[20]	Li, K.; Liu, C.; Kuang, X.; Deng, Q.; Zhao, F.; Li, D. Effects of Multivitamin and Multimineral Supplementation on Blood Pressure: A Meta-Analysis of 12 Randomized Controlled Trials. Nutrients 2018, 10, doi: 10.3390/nu10081018.
[21]	Macpherson, H.; Pipingas, A.; Pase, M. P. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2013, 97, 437-444, doi: 10.3945/ajcn.112.049304.
[22]	Soare, A.; Weiss, E. P.; Holloszy, J. O.; Fontana, L. Multiple dietary supplements do not affect metabolic and cardio-vascular health. Aging (Albany NY) 2014, 6, 149-157, doi: 10.18632/aging.100597.
[23]	Jenkins, D. J. A.; Spence, J. D.; Giovannucci, E. L.; Kim, Y. I.; Josse, R.; Vieth, R.; Blanco Mejia, S.; Viguiliouk, E.; Nishi, S.; Sahye-Pudaruth, S., et al. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol 2018, 71, 2570-2584, doi: 10.1016/j.jacc.2018.04.020.
[24]	Huang, J.; Frohlich, J.; Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Can J Cardiol 2011, 27, 488-505, doi: 10.1016/j.cjca.2010.12.077.
[25]	Laditka, J. N.; Laditka, S. B.; Tait, E. M.; Tsulukidze, M. M. Use of dietary supplements for cognitive health: results of a national survey of adults in the United States. Am J Alzheimers Dis Other Demen 2012, 27, 55-64, doi: 10.1177/1533317511435662.
[26]	Pillitteri, J. L.; Shiffman, S.; Rohay, J. M.; Harkins, A. M.; Burton, S. L.; Wadden, T. A. Use of dietary supplements for weight loss in the United States: results of a national survey. Obesity (Silver Spring) 2008, 16, 790-796, doi: 10.1038/oby.2007.136.
[27]	Anders, S.; Schroeter, C. The impact of nutritional supplement intake on diet behavior and obesity outcomes. PLoS One 2017, 12, e0185258, doi: 10.1371/journal.pone.0185258.
[28]	Angelo, G.; Drake, V. J.; Frei, B. Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials. Crit Rev Food Sci Nutr 2015, 55, 1968-1991, doi: 10.1080/10408398.2014.912199.
[29]	Biswas, S. K. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev 2016, 2016, 5698931, doi: 10.1155/2016/5698931.
[30]	Steven, S.; Frenis, K.; Oelze, M.; Kalinovic, S.; Kuntic, M.; Bayo Jimenez, M. T.; Vujacic-Mirski, K.; Helmstadter, J.; Kroller-Schon, S.; Munzel, T., et al. Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease. Oxid Med Cell Longev 2019, 2019, 7092151, doi: 10.1155/2019/7092151.
[31]	Fernandez-Garcia, J. C.; Cardona, F.; Tinahones, F. J. Inflammation, oxidative stress and metabolic syndrome: dietary modulation. Curr Vasc Pharmacol 2013, 11, 906-919, doi: 10.2174/15701611113116660175.
[32]	Li, C.; Miao, X.; Li, F.; Adhikari, B. K.; Liu, Y.; Sun, J.; Zhang, R.; Cai, L.; Liu, Q.; Wang, Y. Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases. Phytother Res 2019, 33, 1302-1317, doi: 10.1002/ptr.6324.
[33]	Suen, J.; Thomas, J.; Kranz, A.; Vun, S.; Miller, M. Effect of Flavonoids on Oxidative Stress and Inflammation in Adults at Risk of Cardiovascular Disease: A Systematic Review. Healthcare (Basel) 2016, 4, doi: 10.3390/healthcare4030069.
[34]	Fan, L.; Feng, Y.; Chen, G. C.; Qin, L. Q.; Fu, C. L.; Chen, L. H. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2017, 119, 128-136, doi: 10.1016/j.phrs.2017.01.032.
[35]	Moura, F. A.; de Andrade, K. Q.; dos Santos, J. C.; Goulart, M. O. Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications. Curr Top Med Chem 2015, 15, 458-483, doi: 10.2174/1568026615666150114161358.
[36]	Tabrizi, R.; Tamtaji, O. R.; Lankarani, K. B.; Mirhosseini, N.; Akbari, M.; Dadgostar, E.; Peymani, P.; Asemi, Z. The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Food Funct 2018, 9, 6116-6128, doi: 10.1039/c8fo01259h.
[37]	Patel, R. V.; Mistry, B. M.; Shinde, S. K.; Syed, R.; Singh, V.; Shin, H. S. Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem 2018, 155, 889-904, doi: 10.1016/j.ejmech.2018.06.053.
[38]	Dickinson, A.; Blatman, J.; El-Dash, N.; Franco, J. C. Consumer usage and reasons for using dietary supplements: report of a series of surveys. J Am Coll Nutr 2014, 33, 176-182, doi: 10.1080/07315724.2013.875423.
[39]	Fennell, D. Determinants of supplement usage. Prev Med 2004, 39, 932-939, doi: 10.1016/j.ypmed.2004.03.031.
[40]	Wallace, T. C.; McBurney, M.; Fulgoni, V. L., 3rd. Multivitamin/mineral supplement contribution to micronutrient intakes in the United States, 2007-2010. J Am Coll Nutr 2014, 33, 94-102, doi: 10.1080/07315724.2013.846806.
[41]	Moore, J. X.; Chaudhary, N.; Akinyemiju, T. Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988-2012. Prev Chronic Dis 2017, 14, E24, doi: 10.5888/pcd14.160287.
[42]	American Heart Association. Lipid concentrations. Availabe online: http://www.americanheart.org/presenter.jhtml?identifier=183.
[43]	National Center for Health Statistics. Analytic Guidelines, 2011-2014 and 2015-2016. Availabe online: https://wwwn.cdc.gov/nchs/data/nhanes/2011-2012/analyticguidelines/analytic_guidelines_11_16.pdf (accessed on 14 Dec).
[44]	Afolayan, A. J.; Wintola, O. A. Dietary supplements in the management of hypertension and diabetes - a review. Afr J Tradit Complement Altern Med 2014, 11, 248-258, doi: 10.4314/ajtcam.v11i3.35.
[45]	Farias, J. G.; Molina, V. M.; Carrasco, R. A.; Zepeda, A. B.; Figueroa, E.; Letelier, P.; Castillo, R. L. Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress. Nutrients 2017, 9, doi: 10.3390/nu9090966.
[46]	Mozaffari, H.; Daneshzad, E.; Surkan, P. J.; Azadbakht, L. Dietary Total Antioxidant Capacity and Cardiovascular Disease Risk Factors: A Systematic Review of Observational Studies. J Am Coll Nutr 2018, 37, 533-545, doi: 10.1080/07315724.2018.1441079.
[47]	Zemel, M. B. Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension. Mol Cell Biochem 1998, 188, 129-136.
[48]	Cornier, M. A.; Dabelea, D.; Hernandez, T. L.; Lindstrom, R. C.; Steig, A. J.; Stob, N. R.; Van Pelt, R. E.; Wang, H.; Eckel, R. H. The metabolic syndrome. Endocr Rev 2008, 29, 777-822, doi: 10.1210/er.2008-0024.
[49]	Huskisson, E.; Maggini, S.; Ruf, M. The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res 2007, 35, 277-289, doi: 10.1177/147323000703500301.
[50]	Cai, H.; Harrison, D. G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000, 87, 840-844, doi: 10.1161/01.res.87.10.840.
[51]	Son, S. M. Role of vascular reactive oxygen species in development of vascular abnormalities in diabetes. Diabetes Res Clin Pract 2007, 77 Suppl 1, S65-70, doi: 10.1016/j.diabres.2007.01.036.
[52]	Reaven, G. M. The insulin resistance syndrome: definition and dietary approaches to treatment. Annu Rev Nutr 2005, 25, 391-406, doi: 10.1146/annurev.nutr.24.012003.132155.
[53]	Barzegar-Amini, M.; Ghazizadeh, H.; Seyedi, S. M. R.; Sadeghnia, H. R.; Mohammadi, A.; Hassanzade-Daloee, M.; Barati, E.; Kharazmi-Khorassani, S.; Kharazmi-Khorassani, J.; Mohammadi-Bajgiran, M., et al. Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders. Diabetes Metab Syndr 2019, 13, 666-671, doi: 10.1016/j.dsx.2018.11.034.
[54]	Mirhosseini, N.; Rainsbury, J.; Kimball, S. M. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis. Front Cardiovasc Med 2018, 5, 87, doi: 10.3389/fcvm.2018.00087.
[55]	Lim, H. J.; Choi, Y. M.; Choue, R. Dietary intervention with emphasis on folate intake reduces serum lipids but not plasma homocysteine levels in hyperlipidemic patients. Nutr Res 2008, 28, 767-774, doi: 10.1016/j.nutres.2008.08.005.
[56]	Vijayakumar, A.; Kim, E. K.; Kim, H.; Choi, Y. J.; Huh, K. B.; Chang, N. Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus. Nutr Res Pract 2017, 11, 327-333, doi: 10.4162/nrp.2017.11.4.327.
[57]	Philpott, A. C.; Hubacek, J.; Sun, Y. C.; Hillard, D.; Anderson, T. J. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy. Atherosclerosis 2013, 226, 453-458, doi: 10.1016/j.atherosclerosis.2012.10.067.
[58]	Verma, H.; Garg, R. Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysis. J Hum Nutr Diet 2017, 30, 621-633, doi: 10.1111/jhn.12454.
[59]	Jafarnejad, S.; Mahboobi, S.; McFarland, L. V.; Taghizadeh, M.; Rahimi, F. Meta-Analysis: Effects of Zinc Supplementation Alone or with Multi-Nutrients, on Glucose Control and Lipid Levels in Patients with Type 2 Diabetes. Prev Nutr Food Sci 2019, 24, 8-23, doi: 10.3746/pnf.2019.24.1.8.
[60]	Suksomboon, N.; Poolsup, N.; Yuwanakorn, A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther 2014, 39, 292-306, doi: 10.1111/jcpt.12147.
[61]	Albarracin, C.; Fuqua, B.; Geohas, J.; Juturu, V.; Finch, M. R.; Komorowski, J. R. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial. J Cardiometab Syndr 2007, 2, 91-97.
[62]	Wolide, A. D.; Zawdie, B.; Alemayehu, T.; Tadesse, S. Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study. BMC Endocr Disord 2017, 17, 64, doi: 10.1186/s12902-017-0217-z.
[63]	Mao, S.; Zhang, A.; Huang, S. Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Endocrine 2014, 47, 758-763, doi: 10.1007/s12020-014-0298-7.
[64]	Jorat, M. V.; Tabrizi, R.; Mirhosseini, N.; Lankarani, K. B.; Akbari, M.; Heydari, S. T.; Mottaghi, R.; Asemi, Z. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis 2018, 17, 230, doi: 10.1186/s12944-018-0876-4.
[65]	Appel, L. J.; Brands, M. W.; Daniels, S. R.; Karanja, N.; Elmer, P. J.; Sacks, F. M.; American Heart, A. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 2006, 47, 296-308, doi: 10.1161/01.HYP.0000202568.01167.B6.
[66]	Forman, J. P.; Rimm, E. B.; Stampfer, M. J.; Curhan, G. C. Folate intake and the risk of incident hypertension among US women. JAMA 2005, 293, 320-329, doi: 10.1001/jama.293.3.320.
[67]	Ness, A. R.; Chee, D.; Elliott, P. Vitamin C and blood pressure--an overview. J Hum Hypertens 1997, 11, 343-350.
[68]	Borghi, C.; Cicero, A. F. Nutraceuticals with a clinically detectable blood pressure-lowering effect: a review of available randomized clinical trials and their meta-analyses. Br J Clin Pharmacol 2017, 83, 163-171, doi: 10.1111/bcp.12902.
[69]	Emami, M. R.; Safabakhsh, M.; Alizadeh, S.; Asbaghi, O.; Khosroshahi, M. Z. Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis. J Hum Hypertens 2019, 33, 499-507, doi: 10.1038/s41371-019-0192-0.
[70]	Aybak, M.; Sermet, A.; Ayyildiz, M. O.; Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung 1995, 45, 1271-1273.
[71]	McRae, M. P. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials. J Chiropr Med 2009, 8, 15-24, doi: 10.1016/j.jcm.2008.09.001.
[72]	Mangoni, A. A.; Sherwood, R. A.; Swift, C. G.; Jackson, S. H. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med 2002, 252, 497-503.
[73]	Bays, H. E.; Rader, D. J. Does nicotinic acid (niacin) lower blood pressure? Int J Clin Pract 2009, 63, 151-159, doi: 10.1111/j.1742-1241.2008.01934.x.
[74]	Alaei-Shahmiri, F.; Soares, M. J.; Zhao, Y.; Sherriff, J. The impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trial. Diabetes Metab Syndr 2015, 9, 213-217, doi: 10.1016/j.dsx.2015.04.014.
[75]	Horigan, G.; McNulty, H.; Ward, M.; Strain, J. J.; Purvis, J.; Scott, J. M. Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR. J Hypertens 2010, 28, 478-486, doi: 10.1097/HJH.0b013e328334c126.
[76]	Stranges, S.; Guallar, E. Dietary iron and blood pressure. BMJ 2008, 337, a547, doi: 10.1136/bmj.a547.
[77]	Cappuccio, F. P.; Elliott, P.; Allender, P. S.; Pryer, J.; Follman, D. A.; Cutler, J. A. Epidemiologic association between dietary calcium intake and blood pressure: a meta-analysis of published data. Am J Epidemiol 1995, 142, 935-945, doi: 10.1093/oxfordjournals.aje.a117741.
[78]	Rosenfeldt, F. L.; Haas, S. J.; Krum, H.; Hadj, A.; Ng, K.; Leong, J. Y.; Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens 2007, 21, 297-306, doi: 10.1038/sj.jhh.1002138.
[79]	Zhao, J. V.; Schooling, C. M.; Zhao, J. X. The effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Ann Epidemiol 2018, 28, 249-257 e241, doi: 10.1016/j.annepidem.2018.02.001.
[80]	Balbi, M. E.; Tonin, F. S.; Mendes, A. M.; Borba, H. H.; Wiens, A.; Fernandez-Llimos, F.; Pontarolo, R. Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials. Diabetol Metab Syndr 2018, 10, 18, doi: 10.1186/s13098-018-0318-5.
[81]	Ashor, A. W.; Werner, A. D.; Lara, J.; Willis, N. D.; Mathers, J. C.; Siervo, M. Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials. Eur J Clin Nutr 2017, 71, 1371-1380, doi: 10.1038/ejcn.2017.24.
[82]	Kim, H. H.; Kang, Y. R.; Choi, H. Y.; Lee, J. Y.; Oh, J. B.; Kim, J. S.; Kim, Y. C.; Lee, K. W.; Kwon, Y. I. Postprandial anti-hyperglycemic effect of vitamin B6 (pyridoxine) administration in healthy individuals. Food Sci Biotechnol 2019, 28, 907-911, doi: 10.1007/s10068-018-0534-7.
[83]	Moen, G. H.; Qvigstad, E.; Birkeland, K. I.; Evans, D. M.; Sommer, C. Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study. Am J Clin Nutr 2018, 108, 398-404, doi: 10.1093/ajcn/nqy101.
[84]	Polo, V.; Saibene, A.; Pontiroli, A. E. Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas. Acta Diabetol 1998, 35, 61-64.
[85]	Karkabounas, S.; Papadopoulos, N.; Anastasiadou, C.; Gubili, C.; Peschos, D.; Daskalou, T.; Fikioris, N.; Simos, Y. V.; Kontargiris, E.; Gianakopoulos, X., et al. Effects of alpha-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study. J Med Food 2018, 21, 1197-1203, doi: 10.1089/jmf.2018.0007.
[86]	Wang, X.; Wu, W.; Zheng, W.; Fang, X.; Chen, L.; Rink, L.; Min, J.; Wang, F. Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2019, 10.1093/ajcn/nqz041, doi: 10.1093/ajcn/nqz041.
[87]	Sitasawad, S.; Deshpande, M.; Katdare, M.; Tirth, S.; Parab, P. Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM). Diabetes Res Clin Pract 2001, 52, 77-84.
[88]	Johnson, M. A.; Smith, M. M.; Edmonds, J. T. Copper, iron, zinc, and manganese in dietary supplements, infant formulas, and ready-to-eat breakfast cereals. Am J Clin Nutr 1998, 67, 1035S-1040S, doi: 10.1093/ajcn/67.5.1035S.
[89]	Lee, D. H.; Gross, M. D.; Jacobs, D. R., Jr.; Cardiovascular Risk Development in Young Adults, S. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem 2004, 50, 582-588, doi: 10.1373/clinchem.2003.028852.
[90]	Lee, D. H.; Jacobs, D. R., Jr.; Gross, M.; Kiefe, C. I.; Roseman, J.; Lewis, C. E.; Steffes, M. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem 2003, 49, 1358-1366, doi: 10.1373/49.8.1358.
[91]	Bhardwaj, P.; Khanna, D. Green tea catechins: defensive role in cardiovascular disorders. Chin J Nat Med 2013, 11, 345-353, doi: 10.1016/S1875-5364(13)60051-5.

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Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. (2020). The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences, 8(5), 127-138. https://doi.org/10.11648/j.jfns.20200805.12

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Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J. Food Nutr. Sci. 2020, 8(5), 127-138. doi: 10.11648/j.jfns.20200805.12

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Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J Food Nutr Sci. 2020;8(5):127-138. doi: 10.11648/j.jfns.20200805.12

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@article{10.11648/j.jfns.20200805.12,
  author = {Huifeng Jin and Rolando Lorenzo Maddela and Robert Andrew Sinnott},
  title = {The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {8},
  number = {5},
  pages = {127-138},
  doi = {10.11648/j.jfns.20200805.12},
  url = {https://doi.org/10.11648/j.jfns.20200805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20200805.12},
  abstract = {Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.},
 year = {2020}
}

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TY  - JOUR
T1  - The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
AU  - Huifeng Jin
AU  - Rolando Lorenzo Maddela
AU  - Robert Andrew Sinnott
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.jfns.20200805.12
DO  - 10.11648/j.jfns.20200805.12
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 127
EP  - 138
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20200805.12
AB  - Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
VL  - 8
IS  - 5
ER  -

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Author Information

Huifeng Jin

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Rolando Lorenzo Maddela

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA
Robert Andrew Sinnott

Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA

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Plain Text BibTeX RIS

APA Style

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. (2020). The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences, 8(5), 127-138. https://doi.org/10.11648/j.jfns.20200805.12

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ACS Style

Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J. Food Nutr. Sci. 2020, 8(5), 127-138. doi: 10.11648/j.jfns.20200805.12

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AMA Style

Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J Food Nutr Sci. 2020;8(5):127-138. doi: 10.11648/j.jfns.20200805.12

Copy | Download

@article{10.11648/j.jfns.20200805.12,
  author = {Huifeng Jin and Rolando Lorenzo Maddela and Robert Andrew Sinnott},
  title = {The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {8},
  number = {5},
  pages = {127-138},
  doi = {10.11648/j.jfns.20200805.12},
  url = {https://doi.org/10.11648/j.jfns.20200805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20200805.12},
  abstract = {Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
AU  - Huifeng Jin
AU  - Rolando Lorenzo Maddela
AU  - Robert Andrew Sinnott
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.jfns.20200805.12
DO  - 10.11648/j.jfns.20200805.12
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 127
EP  - 138
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20200805.12
AB  - Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
VL  - 8
IS  - 5
ER  -

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