Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats
Journal of Food and Nutrition Sciences
Volume 3, Issue 3-1, May 2015, Pages: 1-4
Received: Dec. 15, 2014; Accepted: Dec. 16, 2014; Published: Feb. 27, 2015
Views 3087      Downloads 158
Authors
Mari Kimoto, Physiological Laboratories, Japan Women's University, Tokyo, Japan
Jorge L. Zeredo, Graduate Program in Health Sciences and Technology, University of Brasilia, Brasilia, Brazil; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Masato S. Ota, Laboratory of Biochemistry and Food Biology, Japan Women's University, Tokyo, Japan
Zenro Nihei, Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Kazuo Toda, Physiological Laboratories, Japan Women's University, Tokyo, Japan; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Article Tools
Follow on us
Abstract
We investigated the effects of somatostatin on the ileal movements after gravity stress and compared these effects between male and female rats. Using an in vitro preparation, measurements of ileal movements evoked by somatostatin application were done at 1, 3, 15 and 30 days after 3G gravity loading-conditioning. Mixed phasic and tonic patterns were observed in the ileal muscle activities. Gravity-stress decreased or antagonized somatostatin inhibitory effects on tonic ileal contraction at an early stage (at day 3) in females, but not in males, indicating that sex differences exist in the way that changes of somatostatin sensitivity is modulated by stress conditioning.
Keywords
Somatostatin, Gravity Stress, Ileum, Sex Difference, Rat
To cite this article
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda, Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats, Journal of Food and Nutrition Sciences. Special Issue: Effects of Foods on Gastrointestinal, Metabolic and Immunological Function. Vol. 3, No. 3-1, 2015, pp. 1-4. doi: 10.11648/j.jfns.s.2015030301.11
References
[1]
Adam ,T.C., Epel, E.S.(2007). Stress, eating and the reward system. Physiol. Behav. 91:449-358.
[2]
Patterson, Z.R., Abizaid, A. (2013). Stress induced obesity: lessons from rodent models of stress. Front. Neurosci. 7:130. doi: 10.3389/fnins.2013.00130.
[3]
Yau, Y.H., Potenza, M.N. (2013). Stress and eating behaviors.,Minerva Endocrinology 38:255-267.
[4]
Torres, S.J., Nowson, C.A. (2007). Relationship between stress, eating behavior, and obesity. Nutrition. 23:887-894.
[5]
Marti O, Marti J, Armario A. (1994). Effects of chronic stress on food intakein rats: influence of stressor intensity and duration of daily exposure.Physiol. Behav .55:747–53
[6]
Rowland, N.E., Antelman, S.M. (1976). Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity. Science191:310–312.
[7]
Wallach,M.B., Dawber, M., McMahon,M., Rogers, C. (1977). A new anorexigen assay: stress-induced hyperphagia in rats. Pharmacol. Biochem. Behav. 6:529–531.
[8]
Whirledge,S., Cidlowski, J.A.A. (2013). Role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. Endocrinology. 154:4450-4468.
[9]
Machado, T.D., Dalle Molle, R., Laureano, D.P,. Portella, A.K., Werlang, I.C., Benetti C.da, S., Noschang, C., Silveira, P.P. (2013). Early life stress is associated with anxiety, increased stress responsivity and preference for "comfort foods" in adult female rats. Stress 16:549-556.
[10]
Lucassen, P.J., Pruessner, J., Sousa, N., Almeida, O.F., Van Dam, A.M., Rajkowska, G., Swaab, D.F., Czéh, B. (2014). Neuropathology of stress. Acta Neuropathol. 127:109-135.
[11]
Aguilera. G.(2011). HPA axis responsiveness to stress: implications for healthy aging. Exp. Gerontol. 46:90-95.
[12]
Maniam, J., Morris, M.J. (2012). The link between stress and feeding behaviour. Neuropharmacology 63:97-110.
[13]
Levy, B.H., Tasker, J.G. (2012). Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress. Front Cell Neurosci. 6:24. doi: 10.3389/fncel.2012.00024
[14]
Abdu, F., Hicks, G.A., Hennig, G., Allen, J.P,. Grundy, D. (2002). Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. Am. J. Physiol .Gastrointest. Liver Physiol. 282:624-633.
[15]
Guillemin, R. (1976). Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus. Endocrinology 99:1653–1654.
[16]
Furness, J.B., Costa, M. (1979). Actions of somatostatin on excitatory and inhibitory nerves in the intestine. Eur. J. Pharmacol. 56:69–74.
[17]
Feniuk, W., Dimech, J., Humphrey, P.P. (1993). Characterization of somatostatin receptors in guinea-pig isolated ileum, vas deferens and right atrium. Br. J. Pharmacol. 110:1156–1164.
[18]
Pizzuto, G., Surgo, D., Clementi, M., Marsico, R., Genco, A., Materia, A., Basso, N. (1997).Differential effect of stress on gastric somatostatin, prostaglandin E and gastrin release in the rat. Ital J Gastroenterol Hepatol. 29:143-147.
[19]
Aguila, M.C., Pickle, R.L.,Yu, W.H., McCann, S.M.(1991). Roles of somatostatin and growth hormone-releasing factor in ether stress inhibition of growth hormone release. Neuroendocrinology 54:515–520.
[20]
Kimoto, M., Zeredo, J.L., Toda, K. (2011). Irritant-drinking behaviour can be modified by gravity-stress loaded in developing but not in adult rats. Stress Health 27:34–41.
[21]
Kimoto, M., Zeredo, J.L., Toda, K. (2012). Hypergravity conditioning on ileal movements in rats. Aviat. Space Environ. Med. 83:483–487.
[22]
Kimoto, M., Zeredo, J.L.,Ota, M.S., Nihei, Z., Toda,K.(2014). Comparison of stress-induced modulation of smooth-muscle activity between ileum and colon in male rats, Auton. Neurosci., 183:8-11.
[23]
McEwen, B.S. (2011). Stress, sex and neural adaptation to a changing environment: mechanisms of neuronal remodeling. Ann. N. Y. Acad. Sci. 1204(Suppl): 38–59.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186