Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats
Journal of Food and Nutrition Sciences
Volume 3, Issue 3-1, May 2015, Pages: 5-8
Received: Feb. 9, 2015; Accepted: Feb. 10, 2015; Published: Feb. 27, 2015
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Authors
Mari Kimoto, Physiological Laboratories, Japan Women's University, Tokyo, Japan
Jorge L. Zeredo, Graduate Program in Health Sciences and Technologies,University of Brasilia, Brasilia, Brazil; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Masato S. Ota, Laboratory of Biochemistry and Food Biology, Japan Women's University, Tokyo, Japan
Zenro Nihei, Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Kazuo Toda, Physiological Laboratories, Japan Women's University, Tokyo, Japan; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
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Abstract
Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.
Keywords
Ginger, Zingerone, Ileum, Motility, Sex Difference, Rat
To cite this article
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda, Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats, Journal of Food and Nutrition Sciences. Special Issue: Effects of Foods on Gastrointestinal, Metabolic and Immunological Function. Vol. 3, No. 3-1, 2015, pp. 5-8. doi: 10.11648/j.jfns.s.2015030301.12
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