Sansho Intake Modulates Ileum Activity in Stress-loaded Rats
Journal of Food and Nutrition Sciences
Volume 3, Issue 3-1, May 2015, Pages: 9-12
Received: Jun. 25, 2015; Accepted: Jun. 27, 2015; Published: Jul. 3, 2015
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Authors
Mari Kimoto, Physiological Laboratories, Japan Women's University, Tokyo, Japan
Jorge L. Zeredo, Graduate Program in Health Science and Technology, University of Brasilia, Brasilia, Brazil; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Masato S. Ota, Laboratory of Biochemistry and Food Biology, Japan Women's University, Tokyo, Japan
Zenro Nihei, Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Kazuo Toda, Physiological Laboratories, Japan Women's University, Tokyo, Japan; Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
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Abstract
Sansho (Japanese pepper) is a common spice widely used in Japanese cuisine. In addition, it is also an important component in Kampo medicine, such as in Daiken Chuto, which stimulates gastrointestinal motility and improves postoperative ileus. On the other hand, we previously reported that gravity stress loading produce negative effects on ileal movements. In the present study, we report changes in ileal motility after gravity-stress with and without Sansho intake in male and female rats. Ileal movements were activated by topical Acetylcholine (Ach) application, and maximum amplitudes (MA) of the evoked contraction were compared. Clear tonic patterns were observed in the ileal motility after Ach application. After short-term stress, there were no significant differences in MA between control and Sansho-intake groups in both sexes. However, after long-term stress-loading, significant enhancement of MA was observed in Sansho-intake group in males, but not in females. The present study showed that SAN affected Ach-induced ileal motility in the male, but not in the female after long-term stress loading, indicating sex differences in effects of Sansho intake. It is suggested that Sansho is more effective in males than in females to decrease negative stress response.
Keywords
Sansho (Japanese Pepper), Ileum, Stress, Motility, Sex Difference, Rat
To cite this article
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda, Sansho Intake Modulates Ileum Activity in Stress-loaded Rats, Journal of Food and Nutrition Sciences. Special Issue: Effects of Foods on Gastrointestinal, Metabolic and Immunological Function. Vol. 3, No. 3-1, 2015, pp. 9-12. doi: 10.11648/j.jfns.s.2015030301.13
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