Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.
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Journal of Food and Nutrition Sciences (Volume 3, Issue 3-1)
This article belongs to the Special Issue Effects of Foods on Gastrointestinal, Metabolic and Immunological Function |
| DOI | 10.11648/j.jfns.s.2015030301.12 |
| Page(s) | 5-8 |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ginger, Zingerone, Ileum, Motility, Sex Difference, Rat
| [1] | Malhotra, S., Singh, A.P. (2003). Medicinal properties of Ginger (Zingiber officinale Rosc.). Natural Product Radiance 2:296-301. |
| [2] | Thomson, M., Al-Qattan, K.K., Al-Sawan, S.M., Alnaqeeb, M. A., Khan, I., Ali, M. (2002). The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids. 67:475-458. |
| [3] | Pereira, M.M., Haniadka., R, Chacko, P.P., Palatty, P.L., Baliga, M.S. (2011). Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review. J Buon.;16:414-424. |
| [4] | Haniadka,R., Rajeev,A.G., Palatty,P.L., Arora, A., Baliga,M.S., (2012). Zingiber officinale (Ginger) as an anti-emetic in cancer chemotherapy: A Review. J. Altern. Complementary Med. 18: 440-444. |
| [5] | Ramadan, G., Al-Kahtani, M.A., El-Sayed W.M. (2011). Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 34:291-301. |
| [6] | Changa, J. S.; Wanga, K. C.; Yehd, C. F.; Shiehc,D.E.; Chiang, L. C. (2013). Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell line. J.Ethnopharmacol., 145:146–151. |
| [7] | Suzuki, H., Inadomi, J.M., Hibi, T. (2009). Japanese herbal medicine in functional gastrointestinal disorders.] Neurogastroenterol Motil. 21: 688–696. |
| [8] | Ghayur, M.N., Gilani, A. H. (2005). Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig Dis Sci. 50:1889-1897. |
| [9] | Jalali-Nezhad, A. A., Farajian-Mashhadi, F., Komeili, G., Barkhordari-Ahmadi, F. (2015) The effect of ginger hydroalcholic extract on rat ileal contraction in vitro. Zahedan J Res Med Sci. 15:29-33. |
| [10] | Borrelli, F., Capasso, R., Pinto, A., Izzo, A.A. (2004). Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro. Life Sci. 74:2889-2896. |
| [11] | Sato, K., Kase, Y., Hayakawa,T., Murata, P., Ishige, A., Sasaki, H. (2001). Dai-kenchu-to enhances accelerated small intestinal movement. Biol. Pharmaco. Bull., 24:1122-1126. |
| [12] | Yamahara, J., Huang, Q., Li, Y. H., Xu, L., Fujimura, H. (1990). Gastrointestinal motility enhancing effects of ginger and its active constituents. Chem.Phramaco. Bull., 38:430-431. |
| [13] | Mayer, E. A. (2000). The neurobiology of stress and gastrointestinal disease. Gut, 47:861-869. |
| [14] | Marti, O., Marti, J., Armario, A. (1994). Effects of chronic stress on food intake in rats: Influence of stressor intensity and duration of daily exposure. Physiology & Behavior, 55:747–753. |
| [15] | Torres, S. J., Nowson, C. A. (2007). Relationship between stress, eating behavior, and obesity. Nutrition. 23:887-894. |
| [16] | Marti O, Marti J, Armario A. (1994). Effects of chronic stress on food intake in rats: influence of stressor intensity and duration of daily exposure. Physiol. Behav. 55:747–53. |
| [17] | Rowland, N. E., Antelman, S. M. (1976). Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity. Science 191:310–312. |
| [18] | Wallach, M. B., Dawber, M., McMahon, M., Rogers, C. (1977). A new anorexigen assay: stress-induced hyperphagia in rats. Pharmacol. Biochem. Behav. 6:529–531. |
| [19] | Machado, T. D., Dalle Molle, R., Laureano, D. P,. Portella, A.K., Werlang, I. C., Benetti C. da, S., Noschang, C., Silveira, P. P. (2013). Early life stress is associated with anxiety, increased stress responsivity and preference for "comfort foods" in adult female rats. Stress 16:549-556. |
| [20] | Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F., Van Dam, A. M., Rajkowska, G., Swaab, D. F., Czéh, B. (2014). Neuropathology of stress. Acta Neuropathol. 127:109-135. |
| [21] | Kimoto, M., Zeredo, J. L., Ota, M. S., Nihei, Z., Toda, K.(2014). Comparison of stress-induced modulation of smooth-muscle activity between ileum and colon in male rats, Auton. Neurosci., 183:8-11. |
| [22] | Kimoto, M., Zeredo, J. L., Toda, K. (2012). Hypergravity conditioning on ileal movements in rats. Aviat. Space Environ. Med. 83:483–487. |
| [23] | Edwards, Q. T., Colquist, S., Maradiegue, A. (2005). What's cooking with garlic: is this complementary and alternative medicine for hypertension? J Am Acad Nurse Pract. 17:381-385. |
| [24] | Hoffman, T. (2007). Ginger: an ancient remedy and modern miracle drug. Hawaii Med J. 66:326-327. |
| [25] | McEwen, B. S. (2011). Stress, sex and neural adaptation to a changing environment: mechanisms of neuronal remodeling. Ann. N. Y. Acad. Sci. 1204 (Suppl): 38–59. |
| [26] | Maniam, J., Morris, M. J. (2012). The link between stress and feeding behaviour. Neuropharmacol. 63:97-110. |
| [27] | Yau, Y. H., Potenza, M. N. (2013). Stress and eating behaviors. Minerva Endocrinology 38:255-267. |
| [28] | Keatonga, L., Hayesa, J., Moanea, S., Lehaneb, M., O’Dohertyc, S., Kingstond, R., Fureyb, A. (2014). The effect of simulated gastro-intestinal conditions on the antioxidant activity of herbal preparations made from native Irish hawthorn. J. Herbal Med. 4:127-133. |
| [29] | Allisona, D. B., Fontaineb, K. R., Heshkaa, S., Mentorec, J. L., & Heymsfieldc, S. B. (2001). Alternative treatments for weight loss: A critical review. Critical Reviews in Food Science and Nutrition. 41:1-28. |
| [30] | McNamara, F. N., Randall, A., Gunthorpe, M. J. (2005). Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol.144:781–790. |
| [31] | Geppetti, P., Trevisani, M. (2004). Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function Br. J. Pharmacol. 141: 1313–1320. |
| [32] | Mundey, M. K., Ali, A., Mason, R., Wilson, V. G. (2000). Pharmacological examination of contractile responses of the guinea-pig isolated ileum produced by m-opioid receptor antagonists in the presence of, and following exposure to, morphine. Br J Pharmacol. 131:893-902. |
| [33] | Pertz, H. H., Lehmann, J., Roth-Ehrans, R., Elz, S. (2011). Effects of ginger constituents on the gastrointestinal tract: Role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta Med. 77:973-978. |
APA Style
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. (2015). Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. Journal of Food and Nutrition Sciences, 3(3-1), 5-8. https://doi.org/10.11648/j.jfns.s.2015030301.12
ACS Style
Mari Kimoto; Jorge L. Zeredo; Masato S. Ota; Zenro Nihei; Kazuo Toda. Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. J. Food Nutr. Sci. 2015, 3(3-1), 5-8. doi: 10.11648/j.jfns.s.2015030301.12
AMA Style
Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda. Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats. J Food Nutr Sci. 2015;3(3-1):5-8. doi: 10.11648/j.jfns.s.2015030301.12
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Download@article{10.11648/j.jfns.s.2015030301.12,
author = {Mari Kimoto and Jorge L. Zeredo and Masato S. Ota and Zenro Nihei and Kazuo Toda},
title = {Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats},
journal = {Journal of Food and Nutrition Sciences},
volume = {3},
number = {3-1},
pages = {5-8},
doi = {10.11648/j.jfns.s.2015030301.12},
url = {https://doi.org/10.11648/j.jfns.s.2015030301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.s.2015030301.12},
abstract = {Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.},
year = {2015}
}
TY - JOUR T1 - Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats AU - Mari Kimoto AU - Jorge L. Zeredo AU - Masato S. Ota AU - Zenro Nihei AU - Kazuo Toda Y1 - 2015/02/27 PY - 2015 N1 - https://doi.org/10.11648/j.jfns.s.2015030301.12 DO - 10.11648/j.jfns.s.2015030301.12 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 5 EP - 8 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.s.2015030301.12 AB - Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 μM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading. VL - 3 IS - 3-1 ER -
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