The Effects of High and Low-Dose Cordyceps Militaris-Containing Mushroom Blend Supplementation After Seven and Twenty-Eight Days
American Journal of Sports Science
Volume 6, Issue 1, March 2018, Pages: 1-7
Received: Nov. 30, 2017;
Accepted: Dec. 8, 2017;
Published: Jan. 12, 2018
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Wesley David Dudgeon, Department of Health and Human Performance, College of Charleston, Charleston, United States
Dennison David Thomas, Department of Health and Human Performance, College of Charleston, Charleston, United States
William Dauch, Department of Health and Human Performance, College of Charleston, Charleston, United States
Timothy Paul Scheett, Department of Health and Human Performance, College of Charleston, Charleston, United States
Michael John Webster, School of Health Sciences, Valdosta State University, Valdosta, United States
The purpose of this study was to examine the aerobic performance effect of 1) low-dose mushroom blend supplementation (1.0 - 2.0 g/day) over a prolonged time period of 28 days compared to a placebo and 2) a higher dose of PeakO2 (12 g/day) for seven days compared to placebo supplementation. For Trial 1, 40 young adult (19-34 yrs) subjects met participation criteria and were randomized into one of two groups. The treatment group (T, n=23) consumed 1.0-2.0 g /day of mushroom blend (PeakO2) along with 2.0g of Gatorade powder for 28 days. The control group (C, n=17) consumed placebo (whole wheat flour) and Gatorade powder in identical fashion. At baseline each participant completed a maximal oxygen consumption (VO2max) test, which included a 5-minute economy state from minutes 3-8 along with a Wingate cycle ergometer test (peak power) at least 24 hrs later. Forty-three young adult subjects met participation criteria for Trial 2 and were randomized into one of two groups. T (n=29), consumed 12.0 g /day of mushroom blend (PeakO2) along with 12.0 g of Gatorade powder for one week. C (n=14) consumed placebo (whole wheat flour) and Gatorade powder in identical fashion There were no differences between groups in any variables at baseline. After 28 days of supplementation, T had a significant increase (< 0.05) in time to fatigue, a significant increase in VO2peak (p < 0.05) and a reduction in blood lactate (p < 0.05) during the economy phase. Analysis for trial 2 was conducted stratifying each group by VO2peak at baseline, in which the top 50% of each group was compared to the bottom 50% (Treatment top, MT, Treatment bottom, MB, Control top, CT, Control bottom, CB). The MB group experienced significant (p<0.05) increases in VO2peak. MB increased VO2max significantly (p < 0.05) while MT, CT, and CB did not change significantly. The MT group experienced a significant 3 bpm drop in economy HR from pre- to post-testing (p < 0.05). The PT demonstrated a significant 4.5% increase in peak power from pre- to post-testing (p < 0.05). No other changes were detected. These data suggest that longer duration, lower dose, supplementation of PeakO2 appears to improve endurance performance in apparently healthy young adults. Further, short duration supplementation of higher doses of PeakO2 may improve performance, but differing effects may occur based upon fitness level.
Wesley David Dudgeon,
Dennison David Thomas,
Timothy Paul Scheett,
Michael John Webster,
The Effects of High and Low-Dose Cordyceps Militaris-Containing Mushroom Blend Supplementation After Seven and Twenty-Eight Days, American Journal of Sports Science.
Vol. 6, No. 1,
2018, pp. 1-7.
H. O. Kim and J. W. Yun, "A comparative study on the production of exopolysaccharides between two entomopathogenic fungi Cordyceps militaris and Cordyceps sinensis in submerged mycelial cultures," (in eng), J Appl Microbiol, vol. 99, no. 4, pp. 728-38, 2005.
H. M. Yu, B. S. Wang, S. C. Huang, and P. D. Duh, "Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage," (in eng), J Agric Food Chem, vol. 54, no. 8, pp. 3132-8, Apr 19 2006.
J. J. Cannell, B. W. Hollis, M. B. Sorenson, T. N. Taft, and J. J. Anderson, "Athletic performance and vitamin D," (in eng), Med Sci Sports Exerc, vol. 41, no. 5, pp. 1102-10, May 2009.
C. Xu, J. Lv, Y. M. Lo, S. W. Cui, X. Hu, and M. Fan, "Effects of oat beta-glucan on endurance exercise and its anti-fatigue properties in trained rats," (in eng), Carbohydr Polym, vol. 92, no. 2, pp. 1159-65, Feb 15 2013.
K. R. Hirsch, A. E. Smith-Ryan, E. J. Roelofs, E. T. Trexler, and M. G. Mock, "Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation," (in eng), J Diet Suppl, pp. 1-13, Jul 13 2016.
S. N. Colson, F. B. Wyatt, D. L. Johnston, L. D. Autrey, Y. L. FitzGerald, and C. P. Earnest, "Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation," (in eng), J Strength Cond Res, vol. 19, no. 2, pp. 358-63, May 2005.
C. P. Earnest et al., "Effects of a commercial herbal-based formula on exercise performance in cyclists," (in eng), Med Sci Sports Exerc, vol. 36, no. 3, pp. 504-9, Mar 2004.
A. C. Parcell, J. M. Smith, S. S. Schulthies, J. W. Myrer, and G. Fellingham, "Cordyceps Sinensis (Cordy Max Cs-4) supplementation does not improve endurance exercise performance," (in eng), Int J Sport Nutr Exerc Metab, vol. 14, no. 2, pp. 236-42, Apr 2004.
G. Dai, T. Bao, C. Xu, R. Cooper, and J. S. Zhu, "CordyMax Cs-4 improves steady-state bioenergy status in mouse liver," (in eng), J Altern Complement Med, vol. 7, no. 3, pp. 231-40, Jun 2001.
F. Yan, Y. Zhang, and B. Wang, "Effects of polysaccharides from Cordyceps sinensis mycelium on physical fatigue in mice," Bangladesh Journal of Pharmacology, vol. 7, no. 3, pp. 217-221, 2012.
R. Kumar, P. S. Negi, B. Singh, G. Ilavazhagan, K. Bhargava, and N. K. Sethy, "Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators," (in eng), J Ethnopharmacol, vol. 136, no. 1, pp. 260-6, Jun 14 2011.
A. C. o. S. Medicine, ACSM's Resource Manual For Guidelines for Exercise Testing and Prescription, 7 ed. Wolters Kluwer, 2013.
K. Jung, I. H. Kim, and D. Han, "Effect of medicinal plant extracts on forced swimming capacity in mice," (in eng), J Ethnopharmacol, vol. 93, no. 1, pp. 75-81, Jul 2004.
C. Y. Chen et al., "Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training," (in eng), High Alt Med Biol, vol. 15, no. 3, pp. 371-9, Sep 2014.
Z. Zhang and e. al., "Clinical and laboratory studies of Jin Shui Bao in eliminating oxygen free radicals in elderly senescent Xu-Zheng (Asthenia syndrome) patients," Journal of Management of Traditional Chinese Medicine, vol. 5, pp. 14-18(supplement), 1995.
Z. Cao and Y. Wen, "Therapeutic effect analysis of Jin Shui Bao capsule in treatment of 33 elderly Xu-Zheng (Asthenia syndrome) patients," Journal of Applied Traditional Chinese Medicine, vol. 1, pp. 32-33, 1993.
N. Manabe et al., "Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse," (in eng), Jpn J Pharmacol, vol. 70, no. 1, pp. 85-8, Jan 1996.
Y. Lou, X. Liao, and Y. Lu, "Cardiovascular pharmacological studies of ethanol extracts of Cordyceps mycelia and Cordyceps fermentation solution," Chinese Traditional and Herbal Drugs, vol. 17, no. 5, pp. 7-21, 1986.
W. Wang, "Observations of effects of Jin Shui Bao on SOD activity in COED patients," Journal of Management of Traditional Chinese Medicine, vol. 5, p. 24(supplement), 1995.
Y. Z. Guo, "Medicinal chemistry, pharmacology, and clinical applications of fermented mycelia of Cordyceps sinensis and JinShuBao capsule," Journal of Modern Diagnostics and Therapeutics, no. 1, pp. 60-65, 1986.
Y. Huang et al., "Toxicity study of fermentation Cordyceps mycelia B414," Zhongchenyao Yanjiu, vol. 10, pp. 24-25, 1987.