American Journal of Sports Science

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The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Received: 15 February 2015    Accepted: 27 February 2015    Published: 04 March 2015
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Abstract

The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.

DOI 10.11648/j.ajss.20150302.11
Published in American Journal of Sports Science (Volume 3, Issue 2, March 2015)
Page(s) 29-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

NGAL, IL6, Cycling performance, Quercetin, Resveratrol

References
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Author Information
  • University of Balikesir, Physical Education and Sports, Balikesir, Turkey

  • University of Balikesir, Faculty of Medicine, Department of Medical Biochemistry, Balikesir Turkey

  • University of Balikesir, Faculty of Medicine, Department of Medical Biochemistry, Balikesir Turkey

  • Liverpool John Moores University, Faculty of Science, Schoool of Pharmacy and Biomolecular Sciences, Liverpool, England (UK)

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    Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. (2015). The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. American Journal of Sports Science, 3(2), 29-35. https://doi.org/10.11648/j.ajss.20150302.11

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    ACS Style

    Zekine Punduk; Adnan Adil Hismiogullari; Ozlem Yavuz; Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am. J. Sports Sci. 2015, 3(2), 29-35. doi: 10.11648/j.ajss.20150302.11

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    AMA Style

    Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am J Sports Sci. 2015;3(2):29-35. doi: 10.11648/j.ajss.20150302.11

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  • @article{10.11648/j.ajss.20150302.11,
      author = {Zekine Punduk and Adnan Adil Hismiogullari and Ozlem Yavuz and Khalid Rahman},
      title = {The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response},
      journal = {American Journal of Sports Science},
      volume = {3},
      number = {2},
      pages = {29-35},
      doi = {10.11648/j.ajss.20150302.11},
      url = {https://doi.org/10.11648/j.ajss.20150302.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajss.20150302.11},
      abstract = {The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response
    AU  - Zekine Punduk
    AU  - Adnan Adil Hismiogullari
    AU  - Ozlem Yavuz
    AU  - Khalid Rahman
    Y1  - 2015/03/04
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajss.20150302.11
    DO  - 10.11648/j.ajss.20150302.11
    T2  - American Journal of Sports Science
    JF  - American Journal of Sports Science
    JO  - American Journal of Sports Science
    SP  - 29
    EP  - 35
    PB  - Science Publishing Group
    SN  - 2330-8540
    UR  - https://doi.org/10.11648/j.ajss.20150302.11
    AB  - The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.
    VL  - 3
    IS  - 2
    ER  - 

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