The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents
International Journal of Medical Imaging
Volume 4, Issue 3, May 2016, Pages: 17-22
Received: Jun. 16, 2016;
Accepted: Jul. 5, 2016;
Published: Jul. 18, 2016
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Iliya Mikhailovich Strekalov, Central City Clinical Hospital No. 1, Ekaterinburg, Russia
Leonid Petrovich Larionov, Department of Pharmacology and Clinical Pharmacology, Faculty of Pharmacy, Ural State Medical University, Ekaterinburg, Russia
Мikhail Georgievich Zuev, Oxide Systems Laboratory, Institute of Solid State Chemistry, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia
Elena Yuryevna Zhuravleva, Experimental Physics Department, Physico-Technical Institute, Ural Federal University Named After the First President of Russia B. N. Yeltsin, Ekaterinburg, Russia
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It is known that there is a high risk of progression of side effects in kidneys, so-called nephropathy induced with X-ray contrast agents, at applying of water-soluble X-ray contrast agents in medical practice. New water-insoluble compounds of orthotantalates of rare-earth elements are offered as new X-ray contrast agents for endocavitary administration. The achieved results have shown the absence of general toxic effect on bodies of animals, high X-ray contrast properties in vitro and in vivo experiments. The investigations were performed on white nondescript mice, rats Wistar subtype and Chinchilla rabbits.
X-ray Contract Agents, Nephropathy Induced with X-ray Contrast Agents, Orthotantalates of Rare-Earth Elements
To cite this article
Iliya Mikhailovich Strekalov,
Leonid Petrovich Larionov,
Мikhail Georgievich Zuev,
Elena Yuryevna Zhuravleva,
The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents, International Journal of Medical Imaging.
Vol. 4, No. 3,
2016, pp. 17-22.
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Rosenstrauch L. S. Prevention of complications in X-ray studies with the use of contrast agents / L. S. Rosenstrauch // Vestnik rentgenologii i radiologii. 1978. No. 9, pp. 31 – 35. [in Russian].
Shimanovskii N. L. Contrast agents. Efficient application guide. Moscow: GEOTAR–Media. 2009. 463 p. [in Russian].
John A. K. Renal insufficiency: gadopentetate dimeglumine as a radiographic contrast agent during peripheral vascular interventional procedures / A. K. John, C. G. Stuart, C. W. Arthur // Radiology. 1996. Vol. 198, pp. 579 – 581.
Gomes A. S. Acute renal dysfunction in high–risk patients after angiography: comparison of ionic contrast media / A. S. Gomes, I. F. Lois, I. D. Baxer // Radiology. 1989. Vol. 121, No. 14, pp. 410 – 415.
Sergeyev P. V., Sviridov N. K., Shimanovskii N. L. X-ray contrast agents. Moscow: Meditsina. 1993. 307 p. [in Russian].
Strekalov I. M. A new X-ray contrast agent – lanthanum orthotantalate and possibilities of its application in abdominal surgery (experimental study): candidate of science (medicine) thesis / I. M. Strekalov / Ekaterinburg. 2007, pp. 84 – 87. [in Russian].
Velmas T. / Gd–DTPA as an alternative contrast agent in conventional and interventional and radiology / T. Velmas T. Markkola // Acta Radiol. 1998. Vol. 39, pp. 223 – 226.
Zuev M. G., Larionov L. P. Tantalum X-ray contrast agents (Solid-State Chemistry for Medicine Series). Ekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2002. ISBN 5-7691-1282-4. [in Russian]. 155 p.
New Materials for Medicine / Collective of authors, M. G. Zuev and L. P. Larionov, Eds., Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2006. ISBN 5-7691-1718-4. [in Russian]. 166 p.
Zhuravleva E. Yu. Tantalum X-ray Contrast Media (Solid-State Chemistry for Medicine Series), by M. G. Zuev and L. P. Larionov, Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2002 // Inorganic Materials, Vol. 40, No. 6, 2004, pp. 671 – 672.
Zhuravleva E. Yu. New Materials for Medicine, M. G. Zuev and L. P. Larionov, Eds., Eekaterinburg: Ural. Otd., Ross. Akad. Nauk, 2006 // Inorganic Materials, 2007, Vol. 43, No. 9, p. 1034.
Zuev M. G. and Larionov L. P. "Tantalic Radio-Opaque Drugs. Preclinical Studies" Monography. Lambert Academic Publishing, 2012. 250 p. [in Russian].
Strekalov I. M., Larionov L. P., Zuyev M. G. // Vestnik rentgenologii i radiologii. 2007 NO 1, pp. 45 – 54.