2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI

Yong Guo; Jiang Yan; Qingjun Wang; Jing Zhang; Lijing Shi; Yingying Hu; Yun Zhang

doi:doi:10.11648/j.ijmi.20180603.11

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2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI

Yong Guo, Jiang Yan, Qingjun Wang, Jing Zhang, Lijing Shi, Yingying Hu, Yun Zhang

Published in International Journal of Medical Imaging (Volume 6, Issue 3)

Received: 9 July 2018 Accepted: 23 November 2018 Published: 20 December 2018

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Abstract

Objective To investigate the feasibility of low dose dedicated computed tomography (CT) with IMR technique compared with magnetic resonance imaging (MRI) in preoperative evaluation of breast cancer. Methods Dedicated CT and breast MRI were performed in 21 patients with diagnosed breast mass for preoperative evaluation. A dedicated protocol combined with chest diagnostic CT and dynamic scans of breast was developed with the use of IMR technique as well as optimization of scan parameters to ensure acceptable radiation dose. Image quality evaluations of CT images were performed using a five-point scale. The number, site and size (maximum diameter) of breast lesion were recorded respectively in CT and MRI images. The enhancement patterns of breast lesion were classified to 3 types (washout, plateau, and persistence) according to time intensity curve derived from CT and time signal curve derived from MRI, respectively. Pearson’s correlation, Bland-Altman analysis, and Cohen’s kappa test were used for statistical assessment. Results The mean effective radiation dose of dedicated breast CT, with the image quality diagnostic acceptable for evaluation of breast lesion and pulmonary structures, was (2.15±0.39) mSv, which was no more than a routine chest diagnostic CT. Results of breast lesion number and lesion site obtained by CT and MRI was consistent, with a total of 24 lesions detected in 21 patients. The mean lesion size was (26.5±12.1) mm in CT and (26.1±12.9) mm in MR, respectively. CT showed an excellent correlation with MRI for lesion size (r=0.99, n=24, p<0.0001). Limits of agreement determined by Bland-Altman analysis for lesion extent was (-3.0mm, 3.8mm). Good agreement was observed between CT and MRI for lesion enhancement patterns (kappa value = 0.936, p=0.000). Conclusion Dedicated breast CT imaging with acceptable radiation dose enabled diagnostic image quality and showed good agreement with breast MR imaging in preoperative evaluation of breast cancer.

Published in	International Journal of Medical Imaging (Volume 6, Issue 3)
DOI	10.11648/j.ijmi.20180603.11
Page(s)	18-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Breast Cancer, Computed Tomography, Low Radiation Dose, Iterative Reconstruction

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APA Style

Yong Guo, Jiang Yan, Qingjun Wang, Jing Zhang, Lijing Shi, et al. (2018). 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. International Journal of Medical Imaging, 6(3), 18-24. https://doi.org/10.11648/j.ijmi.20180603.11

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ACS Style

Yong Guo; Jiang Yan; Qingjun Wang; Jing Zhang; Lijing Shi, et al. 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. Int. J. Med. Imaging 2018, 6(3), 18-24. doi: 10.11648/j.ijmi.20180603.11

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AMA Style

Yong Guo, Jiang Yan, Qingjun Wang, Jing Zhang, Lijing Shi, et al. 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. Int J Med Imaging. 2018;6(3):18-24. doi: 10.11648/j.ijmi.20180603.11

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@article{10.11648/j.ijmi.20180603.11,
  author = {Yong Guo and Jiang Yan and Qingjun Wang and Jing Zhang and Lijing Shi and Yingying Hu and Yun Zhang},
  title = {2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI},
  journal = {International Journal of Medical Imaging},
  volume = {6},
  number = {3},
  pages = {18-24},
  doi = {10.11648/j.ijmi.20180603.11},
  url = {https://doi.org/10.11648/j.ijmi.20180603.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20180603.11},
  abstract = {Objective To investigate the feasibility of low dose dedicated computed tomography (CT) with IMR technique compared with magnetic resonance imaging (MRI) in preoperative evaluation of breast cancer. Methods Dedicated CT and breast MRI were performed in 21 patients with diagnosed breast mass for preoperative evaluation. A dedicated protocol combined with chest diagnostic CT and dynamic scans of breast was developed with the use of IMR technique as well as optimization of scan parameters to ensure acceptable radiation dose. Image quality evaluations of CT images were performed using a five-point scale. The number, site and size (maximum diameter) of breast lesion were recorded respectively in CT and MRI images. The enhancement patterns of breast lesion were classified to 3 types (washout, plateau, and persistence) according to time intensity curve derived from CT and time signal curve derived from MRI, respectively. Pearson’s correlation, Bland-Altman analysis, and Cohen’s kappa test were used for statistical assessment. Results The mean effective radiation dose of dedicated breast CT, with the image quality diagnostic acceptable for evaluation of breast lesion and pulmonary structures, was (2.15±0.39) mSv, which was no more than a routine chest diagnostic CT. Results of breast lesion number and lesion site obtained by CT and MRI was consistent, with a total of 24 lesions detected in 21 patients. The mean lesion size was (26.5±12.1) mm in CT and (26.1±12.9) mm in MR, respectively. CT showed an excellent correlation with MRI for lesion size (r=0.99, n=24, p<0.0001). Limits of agreement determined by Bland-Altman analysis for lesion extent was (-3.0mm, 3.8mm). Good agreement was observed between CT and MRI for lesion enhancement patterns (kappa value = 0.936, p=0.000). Conclusion Dedicated breast CT imaging with acceptable radiation dose enabled diagnostic image quality and showed good agreement with breast MR imaging in preoperative evaluation of breast cancer.},
 year = {2018}
}

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TY - JOUR
T1 - 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI
AU - Yong Guo
AU - Jiang Yan
AU - Qingjun Wang
AU - Jing Zhang
AU - Lijing Shi
AU - Yingying Hu
AU - Yun Zhang
Y1 - 2018/12/20
PY - 2018
N1 - https://doi.org/10.11648/j.ijmi.20180603.11
DO - 10.11648/j.ijmi.20180603.11
T2 - International Journal of Medical Imaging
JF - International Journal of Medical Imaging
JO - International Journal of Medical Imaging
SP - 18
EP - 24
PB - Science Publishing Group
SN - 2330-832X
UR - https://doi.org/10.11648/j.ijmi.20180603.11
AB - Objective To investigate the feasibility of low dose dedicated computed tomography (CT) with IMR technique compared with magnetic resonance imaging (MRI) in preoperative evaluation of breast cancer. Methods Dedicated CT and breast MRI were performed in 21 patients with diagnosed breast mass for preoperative evaluation. A dedicated protocol combined with chest diagnostic CT and dynamic scans of breast was developed with the use of IMR technique as well as optimization of scan parameters to ensure acceptable radiation dose. Image quality evaluations of CT images were performed using a five-point scale. The number, site and size (maximum diameter) of breast lesion were recorded respectively in CT and MRI images. The enhancement patterns of breast lesion were classified to 3 types (washout, plateau, and persistence) according to time intensity curve derived from CT and time signal curve derived from MRI, respectively. Pearson’s correlation, Bland-Altman analysis, and Cohen’s kappa test were used for statistical assessment. Results The mean effective radiation dose of dedicated breast CT, with the image quality diagnostic acceptable for evaluation of breast lesion and pulmonary structures, was (2.15±0.39) mSv, which was no more than a routine chest diagnostic CT. Results of breast lesion number and lesion site obtained by CT and MRI was consistent, with a total of 24 lesions detected in 21 patients. The mean lesion size was (26.5±12.1) mm in CT and (26.1±12.9) mm in MR, respectively. CT showed an excellent correlation with MRI for lesion size (r=0.99, n=24, p<0.0001). Limits of agreement determined by Bland-Altman analysis for lesion extent was (-3.0mm, 3.8mm). Good agreement was observed between CT and MRI for lesion enhancement patterns (kappa value = 0.936, p=0.000). Conclusion Dedicated breast CT imaging with acceptable radiation dose enabled diagnostic image quality and showed good agreement with breast MR imaging in preoperative evaluation of breast cancer.
VL - 6
IS - 3
ER -

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Author Information

Yong Guo

Department of Radiology, Navy General Hospital, Beijing, China
Jiang Yan

Clinical Science, Philips Healthcare, Shanghai, China
Qingjun Wang

Department of Radiology, Navy General Hospital, Beijing, China
Jing Zhang

Department of Radiology, Navy General Hospital, Beijing, China
Lijing Shi

Department of Radiology, Navy General Hospital, Beijing, China
Yingying Hu

Department of Radiology, Navy General Hospital, Beijing, China
Yun Zhang

Department of Radiology, Navy General Hospital, Beijing, China

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APA Style

Yong Guo, Jiang Yan, Qingjun Wang, Jing Zhang, Lijing Shi, et al. (2018). 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. International Journal of Medical Imaging, 6(3), 18-24. https://doi.org/10.11648/j.ijmi.20180603.11

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ACS Style

Yong Guo; Jiang Yan; Qingjun Wang; Jing Zhang; Lijing Shi, et al. 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. Int. J. Med. Imaging 2018, 6(3), 18-24. doi: 10.11648/j.ijmi.20180603.11

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AMA Style

Yong Guo, Jiang Yan, Qingjun Wang, Jing Zhang, Lijing Shi, et al. 2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI. Int J Med Imaging. 2018;6(3):18-24. doi: 10.11648/j.ijmi.20180603.11

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@article{10.11648/j.ijmi.20180603.11,
  author = {Yong Guo and Jiang Yan and Qingjun Wang and Jing Zhang and Lijing Shi and Yingying Hu and Yun Zhang},
  title = {2 Milisievert Low Dose Dedicated Breast CT with Iterative Model Reconstruction Technique in Evaluation of Breast Mass: Feasibility Study in Comparison with MRI},
  journal = {International Journal of Medical Imaging},
  volume = {6},
  number = {3},
  pages = {18-24},
  doi = {10.11648/j.ijmi.20180603.11},
  url = {https://doi.org/10.11648/j.ijmi.20180603.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20180603.11},
  abstract = {Objective To investigate the feasibility of low dose dedicated computed tomography (CT) with IMR technique compared with magnetic resonance imaging (MRI) in preoperative evaluation of breast cancer. Methods Dedicated CT and breast MRI were performed in 21 patients with diagnosed breast mass for preoperative evaluation. A dedicated protocol combined with chest diagnostic CT and dynamic scans of breast was developed with the use of IMR technique as well as optimization of scan parameters to ensure acceptable radiation dose. Image quality evaluations of CT images were performed using a five-point scale. The number, site and size (maximum diameter) of breast lesion were recorded respectively in CT and MRI images. The enhancement patterns of breast lesion were classified to 3 types (washout, plateau, and persistence) according to time intensity curve derived from CT and time signal curve derived from MRI, respectively. Pearson’s correlation, Bland-Altman analysis, and Cohen’s kappa test were used for statistical assessment. Results The mean effective radiation dose of dedicated breast CT, with the image quality diagnostic acceptable for evaluation of breast lesion and pulmonary structures, was (2.15±0.39) mSv, which was no more than a routine chest diagnostic CT. Results of breast lesion number and lesion site obtained by CT and MRI was consistent, with a total of 24 lesions detected in 21 patients. The mean lesion size was (26.5±12.1) mm in CT and (26.1±12.9) mm in MR, respectively. CT showed an excellent correlation with MRI for lesion size (r=0.99, n=24, p<0.0001). Limits of agreement determined by Bland-Altman analysis for lesion extent was (-3.0mm, 3.8mm). Good agreement was observed between CT and MRI for lesion enhancement patterns (kappa value = 0.936, p=0.000). Conclusion Dedicated breast CT imaging with acceptable radiation dose enabled diagnostic image quality and showed good agreement with breast MR imaging in preoperative evaluation of breast cancer.},
 year = {2018}
}

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