Cancer Research Journal

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Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells

Received: 17 April 2014    Accepted: 23 May 2014    Published: 10 June 2014
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Abstract

Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P<0.05~P<0.01). There was no significant difference in the ATP concentration between MKM45 cells that were treated with the three Chinese medicinal materials and those exposed to 5-Fu (P>0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.

DOI 10.11648/j.crj.20140203.11
Published in Cancer Research Journal (Volume 2, Issue 3, May 2014)
Page(s) 42-46
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gastric Carcinoma Cells, Anti- Cancer Chinese Medicinal Materials, ATP Concentration

References
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Author Information
  • Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

  • Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

  • Cancer Research Laboratory, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

  • Department of Nuclear Medicine, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

  • Department of Detection Center, Key Laboratory of Biological Medical of Jiangxi, Jiangxi Academy of Medical Science, Jiangxi, Nanchang, China

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    Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. (2014). Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Research Journal, 2(3), 42-46. https://doi.org/10.11648/j.crj.20140203.11

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    ACS Style

    Xuejun Zhan; Daze Xie; Yingyin Hu; Ge Dai; Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res. J. 2014, 2(3), 42-46. doi: 10.11648/j.crj.20140203.11

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    AMA Style

    Xuejun Zhan, Daze Xie, Yingyin Hu, Ge Dai, Yanping Xu. Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells. Cancer Res J. 2014;2(3):42-46. doi: 10.11648/j.crj.20140203.11

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  • @article{10.11648/j.crj.20140203.11,
      author = {Xuejun Zhan and Daze Xie and Yingyin Hu and Ge Dai and Yanping Xu},
      title = {Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells},
      journal = {Cancer Research Journal},
      volume = {2},
      number = {3},
      pages = {42-46},
      doi = {10.11648/j.crj.20140203.11},
      url = {https://doi.org/10.11648/j.crj.20140203.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.20140203.11},
      abstract = {Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Empirical Studies about Inhibiting Proliferation of Zedoary Turmeric oil, Cinobufacini and Solanine on Gastric Carcinoma Cells
    AU  - Xuejun Zhan
    AU  - Daze Xie
    AU  - Yingyin Hu
    AU  - Ge Dai
    AU  - Yanping Xu
    Y1  - 2014/06/10
    PY  - 2014
    N1  - https://doi.org/10.11648/j.crj.20140203.11
    DO  - 10.11648/j.crj.20140203.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 42
    EP  - 46
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20140203.11
    AB  - Purpose: To investigate the anti-proliferative effects of anti-cancer Chinese medicinal materials such as zedoary turmeric oil, cinobufacini and solanine on gastric carcinoma cell line NKM45. Methods: Bioluminescence assay (BLA) was applied to determine the ATP concentration when NKM45 was exposed to the three Chinese medicinal materials. The influence of zedoary turmeric oil on the growth curve of NKM45 cells was also analyzed. And the concentration of ATP was compared with NKM45 cells that were exposed to 5-Fluorouracil(5-Fu). Results: The concentration of ATP was significantly decreased when the NKM45 cells were exposed to the three Chinese medicinal materials and 5-Fu (P0.05). The zedoary turmeric oil significantly inhibited the survival rate of NKM45 cells. Conclusions: Zedoary turmeric oil, cinobufacin, and solanine can inhibit the proliferative activity of NKM45 cells. They have exploitation potential with broad market prospect.
    VL  - 2
    IS  - 3
    ER  - 

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