Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line
Cancer Research Journal
Volume 4, Issue 2, March 2016, Pages: 28-31
Received: Feb. 2, 2016; Accepted: Feb. 18, 2016; Published: Mar. 1, 2016
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Angelo De Martino, Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
Piera Torricelli, Department SPES, University of Molise, Campobasso, Italy
Hanan Mahmoud Abu-Zeid, Faculty of Science, Botany Department, Alexandria University, Alexandria, Egypt
Anna Shevchenko, People’s Friendship University of Russia, Moscow, Russia
Alberto Siciliano, Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
Simone Beninati, Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
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Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.
Water Garlic Extract, Copper, HepG2, p53, p21, AIF
To cite this article
Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, Simone Beninati, Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line, Cancer Research Journal. Vol. 4, No. 2, 2016, pp. 28-31. doi: 10.11648/j.crj.20160402.11
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