The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation
Cancer Research Journal
Volume 4, Issue 2, March 2016, Pages: 32-36
Received: Feb. 19, 2016;
Accepted: Feb. 28, 2016;
Published: Mar. 12, 2016
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Niveen A. Abo-Touk, Department of Clinical Oncology & Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Amir A. Fikry, Departement of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt
El Yamani Fouda, Departement of General Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt
This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (30 patients). All patients received systemic treatment including chemotherapy, hormonal treatment in receptor positive patients and palliative radiotherapy for patients with bone metastases .The median overall survival (OS) was 18 and 11 months in group I and II, respectively; however the difference did not reach statistical significant (p=0.085). The 2-year OS was 46% in group I and 22% in group II. Tumor size, clinical lymph node stage, Eastern Cooperative Oncology Group Performance Status (ECOG- PS) and the number of metastatic sites were significant independent prognostic factors affecting the OS in univariate analysis, and bone metastases was highly statistically significant. In multivariate analysis ECOG- PS was a significant factor and both the number of metastatic sites and bone metastases were highly significant. Although, locoregional surgery tends to increase overall survival in patients presented with metastatic breast cancer and patients with better ECOG- PS and single bone metastasis are more likely to benefit from surgery, further studies are needed involving a large number of cases, multi-institutional trials and longer follow-up to verify these findings.
Niveen A. Abo-Touk,
Amir A. Fikry,
El Yamani Fouda,
The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation, Cancer Research Journal.
Vol. 4, No. 2,
2016, pp. 32-36.
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