Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia
Cancer Research Journal
Volume 4, Issue 3, May 2016, Pages: 43-47
Received: Feb. 2, 2016; Accepted: Feb. 24, 2016; Published: Apr. 1, 2016
Views 3864      Downloads 137
Authors
Syarif Ibrahim, Department of Surgery, Wahidin Sudirohusodo General Hospital, Makassar, Indonesia
Rosdiana Natzir, Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Andi Asadul Islam, Department of Surgery, Neuro Surgery Division, Wahidin Sudirohusodo General Hospital/Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Tjakra Manuaba, Department of Surgery, Sanglah General Hospital/Faculty of Medicine, Udayana University, Denpasar, Indonesia
A. Benyamin Fachruddin, Department of Internal Division, Wahidin Sudirohusodo General Hospital/Faculty of medicine, Hasanuddin University, Makassar, Indonesia
Burhanuddin Bahar, Department of Epidemiology Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
William Hamdani, Department of Surgery, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Husni Cangara, Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Mochammad Hatta, Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Article Tools
Follow on us
Abstract
Background: During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. Aim: To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. Methods: Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. Results: There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (P = 0.089). While Ki-67 had positive association with higher grade malignancy (P = 0.03). However, there was no association between GATA-3 expression and histopathology grading. Conclusion: In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer.
Keywords
GATA-3, p53 and Ki-67, Histopathology Grading, Breast Cancer
To cite this article
Syarif Ibrahim, Rosdiana Natzir, Andi Asadul Islam, Tjakra Manuaba, A. Benyamin Fachruddin, Burhanuddin Bahar, William Hamdani, Husni Cangara, Mochammad Hatta, Correlation Between GATA-3, Ki67 and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia, Cancer Research Journal. Vol. 4, No. 3, 2016, pp. 43-47. doi: 10.11648/j.crj.20160403.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
American Cancer Society. 2009-2010. Breast Cancer Facts and Figures.
[2]
Tjindarbumi, D., Mangunkusumo, R. 2002. Cancer In Indonesia, Present and Future. Jpn J Clin Onco. (Suplement 1) S17-S21.
[3]
Li, F. Y., Wu, S. G., Zhou, J., et al. 2014. Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study. Open One. 9: 2.
[4]
Yoon, B. S. N. K., Maresh, B. S. E. L., et al. 2010. Higher Levels of GATA-3 Predict Better Survival in Women with Breast Cancer. Human Pathology. 41: 1794-1801.
[5]
Mehra, R., Varambally, S., et al. 2005. Identification of GATA-3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis. Cancer Res. 65: 11259-11264.
[6]
Liu, D. P., Song, H., Xu, Y., et al. 2010. A Common Gain of Function of p53 Cancer Mutants in Inducing Genetic Instability. Oncogene. 29: 949-956.
[7]
Cheang, M. C., Chia, S. K., Voduc, D., Gao, D., Leung, S., et al. 2009. Ki-67 Index, HER2 Status, and Prognosis With Luminal B Breast Cancer. Journal of the National Cancer Institute. 101: 736-750.
[8]
Scholzen, T., Gerdes, J. 2000. The Ki-67 Protein: From the Known and The Unknown. Journal of Cellular Physiology. 182: 311-322.
[9]
Goldhirsch, A., Ingle, J. N., Gelbert, R. D., Thurlimann, B., et al. 2009. Thresholds for Therapies: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009. Annals of Oncology. 20: 1319-1329.
[10]
Nishimura, R., Osaka, T. 2010. Clinical Significance of Ki-67 in Neoadjuvant Chemotherapy for Primary Breast Cancer as a Predictor for Chemo sensitivity and for Prognosis. Department of Breast and Endocrine Surgery, Kumamoto City Hospital, Kumamoto, Japan: Japanese Breast Cancer. 17: 269-275.
[11]
Weisner, G. F., Magener, A. 2009. Ki-67 as a Prognostic Molecular Marker in Routine Clinical use in Breast Cancer Patients. The Breast. 18: 135-141.
[12]
Dydensborg, A. B., Rose, A. A. N., et. al. 2009. GATA-3 Inhibits Breast Cancer Growth and Pulmonary Breast Cancer Metastasis. Oncogene.28: 2634-2642.
[13]
Albergaria, A., Joana, P., et al. 2009. Expression of Foxal and GATA-3 in Breast Cancer. The Prognostic Significance in Hormone Receptor-Negative Tumors.
[14]
Sirvent, J. J., Salvado, M. T., et al. 1995. p53 in Breast Cancer. Its Relation to Histological Grade, Lymph-node Status, Hormon Receptors, Cell-Proliferation fraction (Ki-67) and c-erB-2. Immunohistochemical study of 153 Cases. Histopathol.10: 531-539.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186