Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells
Cancer Research Journal
Volume 4, Issue 5, September 2016, Pages: 69-72
Received: Aug. 4, 2016;
Accepted: Aug. 26, 2016;
Published: Sep. 21, 2016
Views 3083 Downloads 109
Torricelli Piera, Department SPES, University of Molise, Campobasso, Italy
Ferorelli Pasquale, University of Tor Vergata, Department of Biology, Rome, Italy
Shevchenko Anna, People’s Friendship University of Russia, Moscow, Russia
Antonelli Francesco, University of Tor Vergata, Department of Biology, Rome, Italy
Siciliano Alberto, University of Tor Vergata, Department of Biology, Rome, Italy
De Martino Angelo, University of Tor Vergata, Department of Biology, Rome, Italy
Beninati Simone, University of Tor Vergata, Department of Biology, Rome, Italy
Follow on us
Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.
Antioxidants, Organ Perfusion, Oxidative Stress, Micronutrients, HCC, Hepatocarcinoma
To cite this article
De Martino Angelo,
Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells, Cancer Research Journal.
Vol. 4, No. 5,
2016, pp. 69-72.
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Antonelli F. & Beninati S. Enhanced survival of B16-F10 melanoma tumour-bearing C57BL6/N mice treated with a mixture of antioxidants in: Recent Res Devel in Life Sci. 2011; 5: 51-60 Research Signpost, Trivandrum India
Torricelli P, Antonelli F, Ferorelli P, De Martino A, Shevchenko A, and Beninati S. Organ culture model of liver for the study of cancer treatment for hepatocellular carcinoma. Cancer Res J. 2016; 4 (2): 37-42.
Kolev Y., Uetake H., Takagi Y., Sugihara K. Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1α) pathway, angiogenic factors production and poor prognosis. Annals of Surgical Oncology. 2008; 15 (8): 2336–2344.
F. Pons, M. Varela, and J. M. Llovet, Staging systems in hepatocellular carcinoma. HPB (Oxford). 2005; 7 (1): 35–41.
Forner A, Reig ME, de Lope CR, Bruix J. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis. 2010; 30 (1): 61-74.
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, et al. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A 2010; 73: 445–461.
Moreno P, Salvadó V. Determination of eight water- and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography. J Chromatogr A. 2000 870 (1-2): 207-215.
Romero Rodriguez MA, Vazquez Oderiz ML, Lopez Hernandez J, Simal Lozano J. Determination of vitamin C and organic acids in various fruits by HPLC. J Chromatogr Sci. 1992; 30 (11): 433-437.
Frith CH, Ward JM, Turusov VS. Tumours of the liver. IARC Sci Publ. 1994; (111): 223–69.
Prasad S, Gupta SC, Tyagi AK. Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Lett. 2016, doi: 10.1016/j.canlet.2016.03.042. [Epub ahead of print]
Ying Wang, Ira Tabas. Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association? J Atheroscler Thromb. 2014; 21 (5): 381–390.
O’Brien W J, Farhan Rizvi. NADPH oxidase expression and production of superoxide by human corneal stromal cells H. Mol Vis. 2009; 15: 2535–2543.
Li G, Scull C, Ozcan L, Tabas I NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol. 2010; 191 (6): 1113–1125.
Torricelli P., Ferorelli P., De Martino A., Antonelli F., Beninati S.. The Influence of Preventive Multiple Micronutrients Supplementation on Liver Steatosis in High- cholesterol Fed C57BL6/N Mice. American Journal of Life Sciences. 2013; 1 (2): 55-60.
Torricelli P., Ferorelli P., De Martino A., Antonelli F. Beninati S.. Preventive Effects of A Mixture of Micronutrients with Antioxidative Properties on Experimentally Induced Prostate Hyperplasia, American Journal of Life Sciences. 2013; 1 (1): 22-26.
Martínez ME, T. Jacobs E, Baron JA, Marshall JR, Byers TJ. Dietary Supplements and Cancer Prevention: Balancing Potential Benefits Against Proven Harms. Natl Cancer Inst. 2012; 104 (10): 732–739.
Thanan R, Oikawa S, HirakuY, Ohnishi S, Ma N, Pinlaor S, Yongvanit P, Kawanishi S, Murata M. Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer. Int J Mol Sci. 2015; 16 (1): 193–217.