Cancer Research Journal
Volume 6, Issue 2, June 2018, Pages: 38-46
Received: Jan. 13, 2018;
Accepted: Jan. 29, 2018;
Published: Mar. 7, 2018
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Francis Agada, Department of Pure and Applied Chemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria
Chika Muhammad, Department of Pure and Applied Chemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria
Ahmad Uba, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
Halilu Emmanuel Mshelia, Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
Halima Lawal Zubairu, Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.
Halilu Emmanuel Mshelia,
Halima Lawal Zubairu,
Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus, Cancer Research Journal.
Vol. 6, No. 2,
2018, pp. 38-46.
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