Cancer Research Journal

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The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps

Received: 15 February 2018    Accepted: 01 March 2018    Published: 22 March 2018
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Abstract

The aim of the current study was to evaluate the expression levels of STAT6, VEGF and microvessel density (MVD) score in nasal polyp tissues and to explore the underlying relationships during the pathogenesis of nasal polyps. 40 cases with surgical removal of nasal polyps were included, comparing with control group of 10 inferior turbinate mucosal tissues resected from nasal septum deviation correction surgery, from the same time period. By immunohistochemistry, the protein expression levels of STAT6, VEGF and MVD were determined. The results showed that the positive expression rate of STAT6 in mucosal epithelium and glands of nasal polyp tissues was 70%, which was significantly higher than that in control group (P < 0.01). The positive expression percentage of VEGF was 75%, which also higher than that in control group (P < 0.01). The MVD values in nasal polyp group was 22.67±7.54, while 7.04±2.63 in control group. The expression of STAT6 was closely related with the expression of VEGF and MVD, increasing with the level of VEGF and MVD. In general, the expression levels of STAT6, VEGF and MVD in nasal polyp group were increased and themselves were positively correlated, indicating the significant importance in the development of nasal polyp.

DOI 10.11648/j.crj.20180602.12
Published in Cancer Research Journal (Volume 6, Issue 2, June 2018)
Page(s) 47-50
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nasal Polyp, STAT6, VEGF, MVD, Nasal Turbinate Tissues

References
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Author Information
  • Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, Guangzhou, China

  • First Class Ward, The First Affiliated Hospital, Jinan University, Guangzhou, China

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  • APA Style

    Qingsong Cao, Jie Zhang. (2018). The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps. Cancer Research Journal, 6(2), 47-50. https://doi.org/10.11648/j.crj.20180602.12

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    ACS Style

    Qingsong Cao; Jie Zhang. The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps. Cancer Res. J. 2018, 6(2), 47-50. doi: 10.11648/j.crj.20180602.12

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    AMA Style

    Qingsong Cao, Jie Zhang. The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps. Cancer Res J. 2018;6(2):47-50. doi: 10.11648/j.crj.20180602.12

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  • @article{10.11648/j.crj.20180602.12,
      author = {Qingsong Cao and Jie Zhang},
      title = {The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps},
      journal = {Cancer Research Journal},
      volume = {6},
      number = {2},
      pages = {47-50},
      doi = {10.11648/j.crj.20180602.12},
      url = {https://doi.org/10.11648/j.crj.20180602.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.crj.20180602.12},
      abstract = {The aim of the current study was to evaluate the expression levels of STAT6, VEGF and microvessel density (MVD) score in nasal polyp tissues and to explore the underlying relationships during the pathogenesis of nasal polyps. 40 cases with surgical removal of nasal polyps were included, comparing with control group of 10 inferior turbinate mucosal tissues resected from nasal septum deviation correction surgery, from the same time period. By immunohistochemistry, the protein expression levels of STAT6, VEGF and MVD were determined. The results showed that the positive expression rate of STAT6 in mucosal epithelium and glands of nasal polyp tissues was 70%, which was significantly higher than that in control group (P P < 0.01). The MVD values in nasal polyp group was 22.67±7.54, while 7.04±2.63 in control group. The expression of STAT6 was closely related with the expression of VEGF and MVD, increasing with the level of VEGF and MVD. In general, the expression levels of STAT6, VEGF and MVD in nasal polyp group were increased and themselves were positively correlated, indicating the significant importance in the development of nasal polyp.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Expression and Significance of STAT6, VEGF and MVD in Nasal Polyps
    AU  - Qingsong Cao
    AU  - Jie Zhang
    Y1  - 2018/03/22
    PY  - 2018
    N1  - https://doi.org/10.11648/j.crj.20180602.12
    DO  - 10.11648/j.crj.20180602.12
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 47
    EP  - 50
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20180602.12
    AB  - The aim of the current study was to evaluate the expression levels of STAT6, VEGF and microvessel density (MVD) score in nasal polyp tissues and to explore the underlying relationships during the pathogenesis of nasal polyps. 40 cases with surgical removal of nasal polyps were included, comparing with control group of 10 inferior turbinate mucosal tissues resected from nasal septum deviation correction surgery, from the same time period. By immunohistochemistry, the protein expression levels of STAT6, VEGF and MVD were determined. The results showed that the positive expression rate of STAT6 in mucosal epithelium and glands of nasal polyp tissues was 70%, which was significantly higher than that in control group (P P < 0.01). The MVD values in nasal polyp group was 22.67±7.54, while 7.04±2.63 in control group. The expression of STAT6 was closely related with the expression of VEGF and MVD, increasing with the level of VEGF and MVD. In general, the expression levels of STAT6, VEGF and MVD in nasal polyp group were increased and themselves were positively correlated, indicating the significant importance in the development of nasal polyp.
    VL  - 6
    IS  - 2
    ER  - 

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