Effect of Second Cycle Pre-induction Chemotherapy in Critically Ill Burkitt’s Lymphoma Children
Cancer Research Journal
Volume 7, Issue 1, March 2019, Pages: 25-32
Received: Feb. 16, 2019; Accepted: Mar. 25, 2019; Published: Apr. 18, 2019
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Emad Moussa, Department of Clinical Oncology, Menufiya University, Shebeen, Egypt; Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt
Asmaa Hamoda, Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt; Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Samah Semary, Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt; Department of Clinical Oncology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
Marwa Romeih, Department of Radiodiagnosis, Faculty of Medicine, Helwan University, Helwan, Egypt; Department of Radiodiagnosis, Children Cancer Hospital Egypt, Cairo, Egypt
Randa Amin, Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Pathology, Children Cancer Hospital Egypt, Cairo, Egypt
Omneya Hassanin, Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt
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Advanced stage Burkiit’s lymphoma (BL) is associated with tumor burden. Toxicities from intensive therapies are significant. The objectives of this study were to analyze the outcome of patients who could not receive induction chemotherapy on time, and were given a 2nd pre-phase (CVP), and to measure the impact of delay on disease outcome. It is a retrospective non randomized study included pediatric patients, suffering from Burkitt’s Lymphoma over 8 years period in CCHE. The result showed that, four hundred and eight patients were diagnosed as Burkitt’s Lymphoma from July 2007 till October 2015, 286 patients (70.1%) received induction on time as per protocol, while 122 patients (29.9%) were not fit to receive their induction chemotherapy on due time. The delay ranged from 6-45 days. While forty five patients (36.88%) out of the delayed patients received 2nd CVP, 16 patients (13.1%) showed relapse/progression. OS among delayed patients who received 2nd CVP versus those who were delayed and were able to receive full induction chemotherapy was (76.1%), (88.7%) respectively. OS in patients who were delayed versus those who were not delayed was (84%), (85.9%) respectively. In conclusion, in critically ill patients delay of chemotherapy in induction phase is important to reduce morbidity and mortality. The delay of chemotherapy has no impact on OS in Burkitt’s lymphoma children. A second pre-phase therapy in our opinion should not be adopted for all critical ill patients who will not tolerate intensive therapy during early phases of treatment, but instead we recommend a recovery from organ toxicity and starting intensive therapy (COPADM) rather than giving 2nd CVP with careful surveillance of disease progression.
Burkitt’s Lymphoma, Second Pre-Induction Phase, Chemotherapy Toxicity
To cite this article
Emad Moussa, Asmaa Hamoda, Samah Semary, Marwa Romeih, Randa Amin, Omneya Hassanin, Effect of Second Cycle Pre-induction Chemotherapy in Critically Ill Burkitt’s Lymphoma Children, Cancer Research Journal. Vol. 7, No. 1, 2019, pp. 25-32. doi: 10.11648/j.crj.20190701.14
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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