Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma
Cancer Research Journal
Volume 7, Issue 2, June 2019, Pages: 33-38
Received: Feb. 19, 2019;
Accepted: Mar. 22, 2019;
Published: Apr. 18, 2019
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Hanafy Hafez, Pediatric Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Enas El Nadi, Pediatric Oncology Department, Beni Suef University, Beni Suef, Egypt
Alaa Younes, Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Gehad Ahmed, Surgery Department, Faculty of Medicine, Helwan University, Helwan, Egypt
Mohamed Saad Zaghloul, Radiation Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Hala Taha, Surgical Pathology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Rania Labib, Clinical Research Department, Children Cancer Hospital Egypt, Cairo, Egypt
Sayed Abdelhamid Fadel, Pediatric Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt
Soha Ahmed, Department of Clinical Oncology, Aswan University, CCHE, Cairo, Egypt
Objectives: To assess the treatment efficiency, outcome and factors affecting the local control of localized bladder/prostate RMS. Patients and methods: Retrospective analysis of 54 patients with localized bladder/prostate RMS treated at Children Cancer Hospital, Egypt between August 2007 and Jan 2017. All patients were treated according to Intergroup Rhabdomyosarcoma Study (IRS -V) and subsequent Children’s Oncology Group COG guidelines. Results: The median age at diagnosis was 3.28 years (range 0.4–13.6). Fifty-one patients (94%) underwent initial biopsy. Complete surgical resection (primary or delayed) was performed in 7 patients (13%). Local control started before/at week 12 in 29 patients (61.7%). Local control methods were: Radiotherapy in 43 patients (79.2%), radiotherapy with surgery in 4 patients (9%), surgery in 1 patient and four patients did not receive local control. With a median follow up of 38.12 months, the 5-year failure-free survival (FFS) and overall (OS) of the whole patients were 60.4 ± 14.5% and 75.4 ± 14.1% respectively. A better 5-year FFS was experienced by those who had early local control (79.2 ± 17% vs. 43.8 ± 25% p= 0.005). Conclusions: Timing of local control and local radiotherapy is crucial and shouldn’t be delayed waiting for further response to the systemic chemotherapy.
Enas El Nadi,
Mohamed Saad Zaghloul,
Sayed Abdelhamid Fadel,
Treatment Efficiency and Problems of Local Control in Localized Bladder/Prostate Rhabdomyosarcoma, Cancer Research Journal.
Vol. 7, No. 2,
2019, pp. 33-38.
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