Bowel Obstruction and Perforation in Pediatric Intestinal Mature B Cell Lymphoma: Incidence, Clinical Features, and Outcome in CCHE
Cancer Research Journal
Volume 7, Issue 2, June 2019, Pages: 45-52
Received: Mar. 19, 2019;
Accepted: Apr. 17, 2019;
Published: May 26, 2019
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Samah Fathy Semary, Department of Clinical Oncology, Faculty of Medicine, Beni - Suef University, Beni- Suef, Egypt; Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt
Hany Abdel Rahman, Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt; Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Gehad Ahmed, Department of Surgery, Helwan University, Cairo, Egypt; Department of Surgery, Children Cancer Hospital Egypt, Cairo, Egypt
Naglaa El Kenaie, Department of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt; Department of Pathology, Children Cancer Hospital Egypt, Cairo, Egypt
Marwa Romeih, Department of Radio-Diagnosis, Helwan University, Cairo, Egypt; Department of Radio–Diagnosis, Children Cancer Hospital Egypt, Cairo, Egypt
Rana Mohy, Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt
Nouran Nagi, Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt
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Bowel perforation or obstruction is life-threatening complications of intestinal lymphoma. Our aim was to define incidence, clinical features, and outcome associated with bowel perforation or obstruction in pediatric intestinal lymphoma. A retrospective, non-randomized study was included all newly diagnosed pediatric intestinal mature B cell lymphoma patients who were operated out of intestinal obstruction or perforation from July 2007 till July 2017 in CCHE. The results showed that, intestinal obstruction or perforation developed in 34 patients (7.5%) out of 456 patients with intestinal mature B cell lymphoma. Median age is 4.85 years. All of them were treated accordingly to NHL LMB 96 protocol . The 5 years OS among patients were operated out of intestinal obstruction, and who were operated out of perforation were 87.7%, 62.9% respectively with no significant statistical differences. Five years OS among patients with viable malignant cell versus no malignant cell was 65.2%, 90.9% respectively with significant P value. The five years OS for patients didn’t have surgery, and who had surgery was 87.9%, 78.6%, respectively, with no significant statistical differences. Multivariate analysis on EFS and OS was done for the overall group and the subgroup. Including age, sex, pathology, clinical stage, elevated LDH, presence of ATLS, showed statically no significance. In Conclusion, Intestinal complication in the form of obstruction with or without intussusception, or obstruction perforation followed by exploration is not adverse prognostic factor for survival in pediatric patients with intestinal mature B cell lymphoma. Operation with viable malignant cell was associated with significant lower outcome.
Bowel Obstruction, Bowel Perforation, Prognostic Factors, Pediatric Intestinal Mature B Cell Lymphoma
To cite this article
Samah Fathy Semary,
Hany Abdel Rahman,
Naglaa El Kenaie,
Bowel Obstruction and Perforation in Pediatric Intestinal Mature B Cell Lymphoma: Incidence, Clinical Features, and Outcome in CCHE, Cancer Research Journal.
Vol. 7, No. 2,
2019, pp. 45-52.
Copyright © 2019 Authors retain the copyright of this article.
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