Cancer Research Journal
Volume 7, Issue 3, September 2019, Pages: 79-86
Received: Jul. 6, 2019;
Accepted: Jul. 25, 2019;
Published: Aug. 10, 2019
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Francisco Tria IV, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Daphne Ang, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Jose Jasper Andal, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Frances Victoria Que, Department of Medical Oncology, St. Luke’s Medical Center, Quezon City, Philippines
Loraine Kay Cabral, Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Rosil Dimalibot, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Rachelle Arah Salamat, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Ma. Luisa Enriquez, Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Sharlynne Bandales, Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Raymundo Lo, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Manuelito Madrid, Institute of Pathology, St. Luke’s Medical Center, Quezon City, Philippines
Marcelo Imasa, Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
Rubi Li, Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequencing. This is the first local study to perform comprehensive BRCA1 and BRCA 2 (all exons) mutational analysis among Filipinos. This study prompts further investigation of the unique variants to enable better understanding of the genetic predisposition to BC among Filipinos.
Francisco Tria IV,
Jose Jasper Andal,
Frances Victoria Que,
Loraine Kay Cabral,
Rachelle Arah Salamat,
Ma. Luisa Enriquez,
Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos, Cancer Research Journal.
Vol. 7, No. 3,
2019, pp. 79-86.
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