Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Nina Gridina; Anatoliy Morozov; Yuriy Ushenin; Vladimir Rozumenko; Nataliya Draguntsova

doi:doi:10.11648/j.crj.20190703.14

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Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova

Published in Cancer Research Journal (Volume 7, Issue 3)

Received: 5 July 2019 Accepted: 12 August 2019 Published: 23 August 2019

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Abstract

Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil - hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the “Plasmon-6” biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil - hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil - hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil – hydrochloride and the absence of the toxic and tumor-stimulating action of the drug.

Published in	Cancer Research Journal (Volume 7, Issue 3)
DOI	10.11648/j.crj.20190703.14
Page(s)	101-105
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Glioblastomas, Tumor-Associated Inflammation, Low Concentrations of Verapamil-Hydrochloride, Life Expectancy

References

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APA Style

Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova. (2019). Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Research Journal, 7(3), 101-105. https://doi.org/10.11648/j.crj.20190703.14

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ACS Style

Nina Gridina; Anatoliy Morozov; Yuriy Ushenin; Vladimir Rozumenko; Nataliya Draguntsova. Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Res. J. 2019, 7(3), 101-105. doi: 10.11648/j.crj.20190703.14

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AMA Style

Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova. Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Res J. 2019;7(3):101-105. doi: 10.11648/j.crj.20190703.14

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@article{10.11648/j.crj.20190703.14,
  author = {Nina Gridina and Anatoliy Morozov and Yuriy Ushenin and Vladimir Rozumenko and Nataliya Draguntsova},
  title = {Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {3},
  pages = {101-105},
  doi = {10.11648/j.crj.20190703.14},
  url = {https://doi.org/10.11648/j.crj.20190703.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.14},
  abstract = {Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil - hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the “Plasmon-6” biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil - hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil - hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil – hydrochloride and the absence of the toxic and tumor-stimulating action of the drug.},
 year = {2019}
}

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TY  - JOUR
T1  - Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period
AU  - Nina Gridina
AU  - Anatoliy Morozov
AU  - Yuriy Ushenin
AU  - Vladimir Rozumenko
AU  - Nataliya Draguntsova
Y1  - 2019/08/23
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190703.14
DO  - 10.11648/j.crj.20190703.14
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 101
EP  - 105
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190703.14
AB  - Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil - hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the “Plasmon-6” biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil - hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil - hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil – hydrochloride and the absence of the toxic and tumor-stimulating action of the drug.
VL  - 7
IS  - 3
ER  -

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Author Information

Nina Gridina

Experimental Department, Romodanov Neurosurgery Institute of the National Academy of Medical Science of Ukraine, Kiev, Ukraine
Anatoliy Morozov

Romodanov Neurosurgery Institute of the National Academy of Medical Science of Ukraine, Kiev, Ukraine
Yuriy Ushenin

Department of Physical and Technological Bases of Sensor Material Science, V. Ye. Lashkaryov Institute of Semiconductor of National Science Academy of Ukraine, Kiev, Ukraine
Vladimir Rozumenko

Clinical Department, Romodanov Neurosurgery Institute of the National Academy of Medical Science of Ukraine, Kiev, Ukraine
Nataliya Draguntsova

Experimental Department, Romodanov Neurosurgery Institute of the National Academy of Medical Science of Ukraine, Kiev, Ukraine

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APA Style

Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova. (2019). Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Research Journal, 7(3), 101-105. https://doi.org/10.11648/j.crj.20190703.14

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ACS Style

Nina Gridina; Anatoliy Morozov; Yuriy Ushenin; Vladimir Rozumenko; Nataliya Draguntsova. Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Res. J. 2019, 7(3), 101-105. doi: 10.11648/j.crj.20190703.14

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AMA Style

Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova. Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period. Cancer Res J. 2019;7(3):101-105. doi: 10.11648/j.crj.20190703.14

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@article{10.11648/j.crj.20190703.14,
  author = {Nina Gridina and Anatoliy Morozov and Yuriy Ushenin and Vladimir Rozumenko and Nataliya Draguntsova},
  title = {Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period},
  journal = {Cancer Research Journal},
  volume = {7},
  number = {3},
  pages = {101-105},
  doi = {10.11648/j.crj.20190703.14},
  url = {https://doi.org/10.11648/j.crj.20190703.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20190703.14},
  abstract = {Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil - hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the “Plasmon-6” biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil - hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil - hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil – hydrochloride and the absence of the toxic and tumor-stimulating action of the drug.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period
AU  - Nina Gridina
AU  - Anatoliy Morozov
AU  - Yuriy Ushenin
AU  - Vladimir Rozumenko
AU  - Nataliya Draguntsova
Y1  - 2019/08/23
PY  - 2019
N1  - https://doi.org/10.11648/j.crj.20190703.14
DO  - 10.11648/j.crj.20190703.14
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 101
EP  - 105
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20190703.14
AB  - Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil - hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the “Plasmon-6” biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil - hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil - hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil – hydrochloride and the absence of the toxic and tumor-stimulating action of the drug.
VL  - 7
IS  - 3
ER  -

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