Background: The aim of this study is to analyze the clinicopathological features, diagnosis and treatment outcome of rare cases of malignant ovarian germ cell tumors in a government tertiary care hospital centre keeping fertility preservation surgery as a goal in young girls below 21 years of age. Methods: This is a retrospective study comprising of 24 patients diagnosed to have malignant ovarian germ cell tumors who attend the department of Radiation Oncology from 1998 to 2019 over 21 years period. The patients were evaluated on the basis of their age, obstetric history, investigations, and serum tumor markers estimation. All patients were staged according to FIGO, ECOG score were noted. Unilateral Salphingo oophorectomy (USO) with or without staging laparotomy surgery was done and BEP chemotherapy regimen was given. Response to treatment was evaluated by regular clinical examination, radiological and tumor marker studies. Results: In our study 17 patients were in FIGO stage III and 6 patients were in stage IV. The size of the primary tumor was 10-20 cm. in 15 patients. The various histology observed was-dysgerminoma -8, malignant teratoma-5, mixed germ cell tumor-5, yok sac tumor-4 and embryonal carcinoma in 2 patients. Eighteen patients underwent fertility preservation surgery i.e. USO - 15, and 3 patients underwent USO with staging laparotomy. In 14 patients 3-4 cycles of adjuvant chemotherapy (BEP regimen) was administered and all of them achieved complete remission. Conclusion: Malignant ovarian germ cell tumors carries excellent prognosis in spite of advanced stage disease. Patients should be referred to oncology centre and to be operated by gynecologic oncologist/ oncosurgeon. Adjuvant chemotherapy should be given to achieve complete remission.
| Published in | Cancer Research Journal (Volume 8, Issue 4) |
| DOI | 10.11648/j.crj.20200804.11 |
| Page(s) | 57-61 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Germ Cell Tumor Ovary, Fertility Preserving Surgery, Neo-adjuvant Chemotherapy, BEP Regimen
| [1] | Stantorm BF and Behram RE, Overview of Pediatrics. In. Nelson Text Book of Pediatrics 17th Ed. Philadelphia: Saunders: 2011 pp1-13. |
| [2] | Chen LH, Yip KC, Wu HJ and Yong SB. Yolk Sac Tumor in an Eight -Year Old Girl: A Case Report and Literature Review. Frontiers in Pediatrics 2019; 7: 169, doi: 10.3389/fped.2019.00169. |
| [3] | Young JL Jr, Wu XC, Roffers SD, Howe HL, Correa C and Weinstein R. Ovarian Cancer in Children and young Adults in the United States 1992-1997. Cancer 2003 (S10) p 2694-2700. |
| [4] | Tewari K, Cappuccini F, Disaia PJ, Berman ML, Manetta A, Kohler MF et al. Malignant ovarian tumors of the ovary. Obstet Gynecol 2000; 95: 128-133. |
| [5] | Matei Daniela, Emerson R and Jubilee Brown. Ovarian Germ Cell Tumors Chapter 24, In: Principles and Practices of Gynecologic Oncology, 2017; 7th Edition by Dennis S Chi, Andrew Berchuck, Don S Dizon and Catheryn M Yashar. (Wolter Kluwer) pp. 708. |
| [6] | Nogales FF, Dulcey I and Preda O. Germ Cell Tumors of the Ovary. An Update. Arch Pathol Lab Med 2014; 138: 351-362. |
| [7] | Baker BA, Frickey L, Yu IT, Hawkins EP, Cushing B and Perlman EJ. DNA content of ovarian immature teratomas and malignant germ cell tumors. Gynecol Oncol 1998; 71 (1): 14-18. |
| [8] | Gershenson DM, Copeland L J, Kavanagh JJ, Cangir A, Junco GD, Saul PB et al. Treatment of Malignant non dysgerminomatous germ cell tumors of the ovary with Vincristine, dactinomycin and cyclophosphamide. Cancer 1985; 56 (12): 2756-2761. |
| [9] | Rana AN, Humad H, Asif AM, Ghannam D and Nadeem N. Germ cell tumor presenting with Precocious Puberty in a Girl in United Arab Emirates. Dubai Medical Journal 2020; 3: 32-36. |
| [10] | Mangili G, Sigismondi C, Gadducci A, Cormio G, Scollo P, Tateo S et al. Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: A MITO-9 retrospective study. Int J Gynecol Cancer 2011, 21 (8): 1414-1421. |
| [11] | Lakshmanan M, Gupta S, Kumar V, Akhtar N, Chaturvedi A, Mishra S et al. Germ Cell Tumor ovary: an institutional experience of treatment and survival outcomes. Indian J Sur Oncol 2018 Jun; 9(2): 215-219. |
| [12] | Maheshwari A, Gupta S, Parikh PM and Tongaonkar HB. Malignant germ cell tumor ovary—experience at Tata Memorial Hospital. Indian J Med Pediatric Oncol 2004; 25(1): 43. |
| [13] | Smith HO, Berwick M, Verschraegen CF, Wiggins C, Lansing L, Muller CY et al. Incidence and survival rates for female malignant germ cell tumors. Obstet Gynecol 2006; 107(5): 1075–1085. |
| [14] | Giorgi UD, Casadei C, Bergamini A, Attademo L, Cormio G, Lorusso D et al. Therapeutic Challenges for Cisplatin- Resistant Ovarian Germ Cell Tumors. Cancers 2019; 11(10): 1584; https://doi.org/10.3390/cancers11101584. |
| [15] | Gershenson DM. Menstrual and reproductive function after treatment with combination chemotherapy for malignant ovarian germ cell tumors. J Clin Oncol. 1988; 6 (2): 270-275. |
| [16] | Perrin LC, Low J, Nicklin JL, Ward BG and Crandon AJ. Fertility and ovarian function after conservative surgery for germ cell tumors of the ovary. Aust N Z J Obstet Gynecol 1999; 39 (2): 243-244. |
| [17] | Ezzat A, Raja M, Bakri Y, Subhi J, Memon M, Schwartz P et al. Malignant ovarian germ cell tumors: a survival and prognostic analysis. Acta Oncol. 1999; 38(4): 455–460. |
| [18] | Brewer M, Gerhenson DM, Herzog CE, Mitchell MF, Silva EG and Wharton JT. Outcomes and reproductive function after chemotherapy for ovarian dysgerminoma. J Clin Oncol 1999; 17 (9): 2670–2675. |
| [19] | Shibata K, Kajiyam H and Kikkawa F. Growing teratoma syndrome of the ovary showing three patterns of metastasis. A Case report. Case Rep Oncol 2013; 6: 544-549. |
APA Style
Rajendra Kumar Tanwar, Bharti Saxena, Shankar Lal Mohanpuria, Harsh Goyal, Laxmi Agarwal, et al. (2020). Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India). Cancer Research Journal, 8(4), 57-61. https://doi.org/10.11648/j.crj.20200804.11
ACS Style
Rajendra Kumar Tanwar; Bharti Saxena; Shankar Lal Mohanpuria; Harsh Goyal; Laxmi Agarwal, et al. Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India). Cancer Res. J. 2020, 8(4), 57-61. doi: 10.11648/j.crj.20200804.11
AMA Style
Rajendra Kumar Tanwar, Bharti Saxena, Shankar Lal Mohanpuria, Harsh Goyal, Laxmi Agarwal, et al. Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India). Cancer Res J. 2020;8(4):57-61. doi: 10.11648/j.crj.20200804.11
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Download@article{10.11648/j.crj.20200804.11,
author = {Rajendra Kumar Tanwar and Bharti Saxena and Shankar Lal Mohanpuria and Harsh Goyal and Laxmi Agarwal and Madhu Saxena and Man Mohan Agarwal},
title = {Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India)},
journal = {Cancer Research Journal},
volume = {8},
number = {4},
pages = {57-61},
doi = {10.11648/j.crj.20200804.11},
url = {https://doi.org/10.11648/j.crj.20200804.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200804.11},
abstract = {Background: The aim of this study is to analyze the clinicopathological features, diagnosis and treatment outcome of rare cases of malignant ovarian germ cell tumors in a government tertiary care hospital centre keeping fertility preservation surgery as a goal in young girls below 21 years of age. Methods: This is a retrospective study comprising of 24 patients diagnosed to have malignant ovarian germ cell tumors who attend the department of Radiation Oncology from 1998 to 2019 over 21 years period. The patients were evaluated on the basis of their age, obstetric history, investigations, and serum tumor markers estimation. All patients were staged according to FIGO, ECOG score were noted. Unilateral Salphingo oophorectomy (USO) with or without staging laparotomy surgery was done and BEP chemotherapy regimen was given. Response to treatment was evaluated by regular clinical examination, radiological and tumor marker studies. Results: In our study 17 patients were in FIGO stage III and 6 patients were in stage IV. The size of the primary tumor was 10-20 cm. in 15 patients. The various histology observed was-dysgerminoma -8, malignant teratoma-5, mixed germ cell tumor-5, yok sac tumor-4 and embryonal carcinoma in 2 patients. Eighteen patients underwent fertility preservation surgery i.e. USO - 15, and 3 patients underwent USO with staging laparotomy. In 14 patients 3-4 cycles of adjuvant chemotherapy (BEP regimen) was administered and all of them achieved complete remission. Conclusion: Malignant ovarian germ cell tumors carries excellent prognosis in spite of advanced stage disease. Patients should be referred to oncology centre and to be operated by gynecologic oncologist/ oncosurgeon. Adjuvant chemotherapy should be given to achieve complete remission.},
year = {2020}
}
TY - JOUR T1 - Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India) AU - Rajendra Kumar Tanwar AU - Bharti Saxena AU - Shankar Lal Mohanpuria AU - Harsh Goyal AU - Laxmi Agarwal AU - Madhu Saxena AU - Man Mohan Agarwal Y1 - 2020/10/27 PY - 2020 N1 - https://doi.org/10.11648/j.crj.20200804.11 DO - 10.11648/j.crj.20200804.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 57 EP - 61 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20200804.11 AB - Background: The aim of this study is to analyze the clinicopathological features, diagnosis and treatment outcome of rare cases of malignant ovarian germ cell tumors in a government tertiary care hospital centre keeping fertility preservation surgery as a goal in young girls below 21 years of age. Methods: This is a retrospective study comprising of 24 patients diagnosed to have malignant ovarian germ cell tumors who attend the department of Radiation Oncology from 1998 to 2019 over 21 years period. The patients were evaluated on the basis of their age, obstetric history, investigations, and serum tumor markers estimation. All patients were staged according to FIGO, ECOG score were noted. Unilateral Salphingo oophorectomy (USO) with or without staging laparotomy surgery was done and BEP chemotherapy regimen was given. Response to treatment was evaluated by regular clinical examination, radiological and tumor marker studies. Results: In our study 17 patients were in FIGO stage III and 6 patients were in stage IV. The size of the primary tumor was 10-20 cm. in 15 patients. The various histology observed was-dysgerminoma -8, malignant teratoma-5, mixed germ cell tumor-5, yok sac tumor-4 and embryonal carcinoma in 2 patients. Eighteen patients underwent fertility preservation surgery i.e. USO - 15, and 3 patients underwent USO with staging laparotomy. In 14 patients 3-4 cycles of adjuvant chemotherapy (BEP regimen) was administered and all of them achieved complete remission. Conclusion: Malignant ovarian germ cell tumors carries excellent prognosis in spite of advanced stage disease. Patients should be referred to oncology centre and to be operated by gynecologic oncologist/ oncosurgeon. Adjuvant chemotherapy should be given to achieve complete remission. VL - 8 IS - 4 ER -
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