Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis

Daxia Cai; Ying Yang; Zewei Jiang; Dongmei He

doi:doi:10.11648/j.crj.20200804.13

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Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis

Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He

Received: 27 October 2020 Accepted: 13 November 2020 Published: 23 November 2020

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Abstract

Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373^*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149^*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.

DOI	10.11648/j.crj.20200804.13
Published in	Cancer Research Journal (Volume 8, Issue 4, December 2020)
Page(s)	68-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bioinformatics Analysis, Differentially Expressed Genes (DE-genes), Differentially Expressed microRNAs (DE-miRNAs), Nasal-type NK/T-cell Lymphoma (nasal-type NKTL), microRNAs

References

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APA Style

Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He. (2020). Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Research Journal, 8(4), 68-81. https://doi.org/10.11648/j.crj.20200804.13

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ACS Style

Daxia Cai; Ying Yang; Zewei Jiang; Dongmei He. Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Res. J. 2020, 8(4), 68-81. doi: 10.11648/j.crj.20200804.13

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AMA Style

Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He. Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Res J. 2020;8(4):68-81. doi: 10.11648/j.crj.20200804.13

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@article{10.11648/j.crj.20200804.13,
  author = {Daxia Cai and Ying Yang and Zewei Jiang and Dongmei He},
  title = {Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis},
  journal = {Cancer Research Journal},
  volume = {8},
  number = {4},
  pages = {68-81},
  doi = {10.11648/j.crj.20200804.13},
  url = {https://doi.org/10.11648/j.crj.20200804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200804.13},
  abstract = {Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.},
 year = {2020}
}

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TY  - JOUR
T1  - Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis
AU  - Daxia Cai
AU  - Ying Yang
AU  - Zewei Jiang
AU  - Dongmei He
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.crj.20200804.13
DO  - 10.11648/j.crj.20200804.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 68
EP  - 81
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20200804.13
AB  - Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.
VL  - 8
IS  - 4
ER  -

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Author Information

Daxia Cai

Institute of Hematology, Jinan University, Guangzhou, P.R. China
Ying Yang

Health Management Center, The First Affiliated Hospital of Jinan University, Guangzhou, China
Zewei Jiang

Department of Respiratory, The First Affiliated Hospital of Jinan University, Guangzhou, China
Dongmei He

Institute of Hematology, Jinan University, Guangzhou, P.R. China

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APA Style

Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He. (2020). Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Research Journal, 8(4), 68-81. https://doi.org/10.11648/j.crj.20200804.13

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ACS Style

Daxia Cai; Ying Yang; Zewei Jiang; Dongmei He. Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Res. J. 2020, 8(4), 68-81. doi: 10.11648/j.crj.20200804.13

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AMA Style

Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He. Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis. Cancer Res J. 2020;8(4):68-81. doi: 10.11648/j.crj.20200804.13

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@article{10.11648/j.crj.20200804.13,
  author = {Daxia Cai and Ying Yang and Zewei Jiang and Dongmei He},
  title = {Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis},
  journal = {Cancer Research Journal},
  volume = {8},
  number = {4},
  pages = {68-81},
  doi = {10.11648/j.crj.20200804.13},
  url = {https://doi.org/10.11648/j.crj.20200804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200804.13},
  abstract = {Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis
AU  - Daxia Cai
AU  - Ying Yang
AU  - Zewei Jiang
AU  - Dongmei He
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.crj.20200804.13
DO  - 10.11648/j.crj.20200804.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 68
EP  - 81
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20200804.13
AB  - Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.
VL  - 8
IS  - 4
ER  -

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