A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor
Cancer Research Journal
Volume 1, Issue 1, May 2013, Pages: 1-6
Received: Apr. 8, 2013;
Published: May 2, 2013
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Takuma Hayashi, Dept. of Immunology and Infectious Disease, Shinshu University Graduate School of Medicine, Matsumoto, Nagano 390-8621, Japan; Promoting Business using Advanced Technology, Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-8666, Japan; Sigma-Aldrich Collaboration Laboratory
Akiko Horiuchi., Horiuchi Ladies Clinic, Matsumoto, Nagano 390-0821, Japan
Nobuo Yaegashi., Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574 Japan
Tanri Shiozawa., Department of Obstetrics and Gynecology, Shinshu University Graduate School of Medicine, Miyagi 390-8621 Japan
Susumu Tonegawa., Picower Institution and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307 USA
Ikuo Konishi, Dept. of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto-city, Kyoto 606-8507, Japan
Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)
A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor, Cancer Research Journal.
Vol. 1, No. 1,
2013, pp. 1-6.
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