A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor

Takuma Hayashi; Akiko Horiuchi.; Nobuo Yaegashi.; Tanri Shiozawa.; Susumu Tonegawa.; Ikuo Konishi

doi:doi:10.11648/j.crj.20130101.11

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A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor

Takuma Hayashi, Akiko Horiuchi., Nobuo Yaegashi., Tanri Shiozawa., Susumu Tonegawa., Ikuo Konishi

Published in Cancer Research Journal (Volume 1, Issue 1)

Received: 8 April 2013 Accepted: Published: 2 May 2013

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Abstract

Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)

Published in	Cancer Research Journal (Volume 1, Issue 1)
DOI	10.11648/j.crj.20130101.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

LMP2/β1i, Uterine Leiomyosarcoma, Uterine Leiomyoma, Biomarker

References

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APA Style

Takuma Hayashi, Akiko Horiuchi., Nobuo Yaegashi., Tanri Shiozawa., Susumu Tonegawa., et al. (2013). A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Research Journal, 1(1), 1-6. https://doi.org/10.11648/j.crj.20130101.11

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ACS Style

Takuma Hayashi; Akiko Horiuchi.; Nobuo Yaegashi.; Tanri Shiozawa.; Susumu Tonegawa., et al. A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Res. J. 2013, 1(1), 1-6. doi: 10.11648/j.crj.20130101.11

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AMA Style

Takuma Hayashi, Akiko Horiuchi., Nobuo Yaegashi., Tanri Shiozawa., Susumu Tonegawa., et al. A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Res J. 2013;1(1):1-6. doi: 10.11648/j.crj.20130101.11

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@article{10.11648/j.crj.20130101.11,
  author = {Takuma Hayashi and Akiko Horiuchi. and Nobuo Yaegashi. and Tanri Shiozawa. and Susumu Tonegawa. and Ikuo Konishi},
  title = {A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.crj.20130101.11},
  url = {https://doi.org/10.11648/j.crj.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130101.11},
  abstract = {Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)},
 year = {2013}
}

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TY  - JOUR
T1  - A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor
AU  - Takuma Hayashi
AU  - Akiko Horiuchi.
AU  - Nobuo Yaegashi.
AU  - Tanri Shiozawa.
AU  - Susumu Tonegawa.
AU  - Ikuo Konishi
Y1  - 2013/05/02
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130101.11
DO  - 10.11648/j.crj.20130101.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130101.11
AB  - Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)
VL  - 1
IS  - 1
ER  -

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Author Information

Takuma Hayashi

Dept. of Immunology and Infectious Disease, Shinshu University Graduate School of Medicine, Matsumoto, Nagano 390-8621, Japan; Promoting Business using Advanced Technology, Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-8666, Japan; Sigma-Aldrich Collaboration Laboratory
Akiko Horiuchi.

Horiuchi Ladies Clinic, Matsumoto, Nagano 390-0821, Japan
Nobuo Yaegashi.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574 Japan
Tanri Shiozawa.

Department of Obstetrics and Gynecology, Shinshu University Graduate School of Medicine, Miyagi 390-8621 Japan
Susumu Tonegawa.

Picower Institution and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307 USA
Ikuo Konishi

Dept. of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto-city, Kyoto 606-8507, Japan

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Takuma Hayashi, Akiko Horiuchi., Nobuo Yaegashi., Tanri Shiozawa., Susumu Tonegawa., et al. (2013). A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Research Journal, 1(1), 1-6. https://doi.org/10.11648/j.crj.20130101.11

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ACS Style

Takuma Hayashi; Akiko Horiuchi.; Nobuo Yaegashi.; Tanri Shiozawa.; Susumu Tonegawa., et al. A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Res. J. 2013, 1(1), 1-6. doi: 10.11648/j.crj.20130101.11

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AMA Style

Takuma Hayashi, Akiko Horiuchi., Nobuo Yaegashi., Tanri Shiozawa., Susumu Tonegawa., et al. A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor. Cancer Res J. 2013;1(1):1-6. doi: 10.11648/j.crj.20130101.11

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@article{10.11648/j.crj.20130101.11,
  author = {Takuma Hayashi and Akiko Horiuchi. and Nobuo Yaegashi. and Tanri Shiozawa. and Susumu Tonegawa. and Ikuo Konishi},
  title = {A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.crj.20130101.11},
  url = {https://doi.org/10.11648/j.crj.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130101.11},
  abstract = {Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor
AU  - Takuma Hayashi
AU  - Akiko Horiuchi.
AU  - Nobuo Yaegashi.
AU  - Tanri Shiozawa.
AU  - Susumu Tonegawa.
AU  - Ikuo Konishi
Y1  - 2013/05/02
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130101.11
DO  - 10.11648/j.crj.20130101.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130101.11
AB  - Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which distinguishes malignant LMS from benign tumor leiomyoma (LMA), is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, to establish a treatment method. Proteasome LMP2/1i-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2/1i expression to be absent in human LMS, but present in human LMA. Therefore, defec-tive-LMP2/1i expression may be one of the risk factors for LMS. LMP2/1i is a potential diagnostic-biomarker under the combination of candidate molecules for uterine mesenchymal tumors, especially uterine LMS, and may be a tar-geted-molecule for a new therapeutic approach. (160 words)
VL  - 1
IS  - 1
ER  -

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