Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients
Science Journal of Clinical Medicine
Volume 2, Issue 4, July 2013, Pages: 129-133
Received: Jun. 21, 2013; Published: Jul. 10, 2013
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Aris Lacis, Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia
Inguna Lubaua, Riga Stradins University, Riga, Latvia
Andrejs Erglis, Latvian Institute of Cardiology, Riga, Latvia
Andis Lacis, Riga Stradins University, Riga, Latvia
Inta Bergmane, Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia
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This retrospective report presents findings on 7 patients with idiopathic dilated cardiomyopathy who underwent transplantation of autologous bone marrow derived mononuclear cells (BMSC) after failed routine conservative treatment, and were on a waiting list for cardiac transplantation. In two out of seven patients, we performed intramyocardial delivery of BMSC twice, 22 and 24 months respectively after the first transplant. All patients received anti-congestive therapy by diu-retics, ACE inhibitors, carvedilol, digitalis and aspirin. We discuss potential disadvantages of intracoronary injections of autologous bone marrow stem cells. We believe that our BMSC transplantation method as opposed to intravascular input is the method of choice, particularly in children with idiopathic dilated cardiomyopathy because it is safe, gentle and is not associated with risks for coronary circulation.
Idiopathic Dilated Cardiomyopathy (IDCM) In Children, Bone Marrow Stem Cells (BMSC), Intramyocardial BMSC Transplantation
To cite this article
Aris Lacis, Inguna Lubaua, Andrejs Erglis, Andis Lacis, Inta Bergmane, Management of Idiopathic Dilated Cardiomyopathy with Intramyocardial Stem Cell Transplantation in Children: A Retrospective Study of 7 Patients, Science Journal of Clinical Medicine. Vol. 2, No. 4, 2013, pp. 129-133. doi: 10.11648/j.sjcm.20130204.12
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