Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences
Science Journal of Clinical Medicine
Volume 3, Issue 4, July 2014, Pages: 70-74
Received: Jun. 18, 2014; Accepted: Jul. 29, 2014; Published: Aug. 10, 2014
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Authors
Julian Ananiev, Department of General and Clinical Pathology and Forensic Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Mariana Penkova, Department of Internal medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Kiril Slaveykov, Department of Ophthalmology and General medicine, Medical Faculty, Trakia Univercity, Stara Zagora, Bulgaria
Georgi Tchernev, Saint Kliment Ohridski University, Medical Faculty, University Hospital Lozenetz, Sofia, Bulgaria
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Abstract
Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.
Keywords
Gastric Blood Vessels, CD31, CD34, Von Willebrand Factor, VEGF
To cite this article
Julian Ananiev, Mariana Penkova, Kiril Slaveykov, Georgi Tchernev, Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences, Science Journal of Clinical Medicine. Vol. 3, No. 4, 2014, pp. 70-74. doi: 10.11648/j.sjcm.20140304.13
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