Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences
Science Journal of Clinical Medicine
Volume 3, Issue 4, July 2014, Pages: 70-74
Received: Jun. 18, 2014;
Accepted: Jul. 29, 2014;
Published: Aug. 10, 2014
Views 2672 Downloads 155
Julian Ananiev, Department of General and Clinical Pathology and Forensic Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Mariana Penkova, Department of Internal medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
Kiril Slaveykov, Department of Ophthalmology and General medicine, Medical Faculty, Trakia Univercity, Stara Zagora, Bulgaria
Georgi Tchernev, Saint Kliment Ohridski University, Medical Faculty, University Hospital Lozenetz, Sofia, Bulgaria
Follow on us
Dieulafoy's lesion (DL) is a rare of cases of acute upper GIT bleeding. We investigate the immunohistochemical expression of several endothelial markers in a patient with Dieulafoy’s lesion of the stomach, by comparing the results with data on the expression of these markers in other types of gastric pathology. The histological examination of the patient with Dieulafoy’s lesion showed small erosive defect covered with fibrin, under which there were several highly deformed and dilated blood vessels with different diameters. We found that the expression of EC markers CD31, CD34, vWF and VEGF in gastric blood vessels of DL is heterogeneous and there is some differences compared with endothelial markers expression in other gastric pathology.
Gastric Blood Vessels, CD31, CD34, Von Willebrand Factor, VEGF
To cite this article
Immunohistochemical Expression of Endothelial Cell Markers in Case of Dieulafoy Lesion: Is There Is a Differences, Science Journal of Clinical Medicine.
Vol. 3, No. 4,
2014, pp. 70-74.
Choi YC, Park SH, Bang BW, Kwon KS, Kim HG, Shin YW. Two cases of ileal dieulafoy lesion with massive hematochezia treated by single balloon enteroscopy. Clin Endosc. 2012 Nov;45(4):440-3.
Morowitz M, Markowitz R, Kamath B, Allmen D. Dieulafoy’s lesion segmental dilatation of the small bowel: an uncommon cause of gastrointestinal bleeding. J Paediatr Surg 2004; 39: 1726–8.
Marangoni G, Cresswell AB, Faraj W, Shaikh H, Bowles MJ. An uncommon cause of life-threatening gastrointestinal bleeding: 2 synchronous Dieulafoy lesions. J Paediatr Surg 2009; 44: 441–3.
Muller AM, Hermanns MI, Skrzynski C, Nesslinger M, Muller KM, Kirppatrick J Expression of the endothelial markers PECAM-1, VWf and CD34 in vivo and in vitro. Exp Mol Pathol 2002a; 72:221–229.
Ogawa K, Oguchi M, Yamabe H, et al. Distribution of collagen type IV in soft tissue tumors: An immunohistochemical study. Cancer. 1986;58:269-277.
Weiss HJ. von Willebrand factor and platelet function. Ann NY Acad Sci, 1991; 614:125–137.
Muller AM, Skrzynski C, Skipka G, Muller KM. Expression of vonWillebrand factor by human pulmonary endothelial cells in vivo. Respiration (Herrlisheim), 2002c; 69:526–533.
Marelli-Berg FM, Clement M, Mauro C, Caligiuri G. An immunologist's guide to CD31 function in T-cells. J Cell Sci. 2013 Jun 1;126(Pt 11):2343-52.
Pusztaszeri MP, Seelentag W, Bosman FT. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem. 2006 Apr;54(4):385-95.
Ferrara N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 2009;29:789–91.
FerraraN,Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4–25.
Dvorak HF, Sioussat TM, Brown LF, et al. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J Exp Med 1991;174:1275–8.
Pousa ID, Gisbert JP. Gastric angiogenesis and Helicobacter pylori infection. Rev Esp Enferm Dig. 2006 Jul;98(7):527-41.
Hudson N, Balsitis M, Everitt S, Hawkey CJ. Angiogenesis in gastric ulcers: impaired in patients taking non-steroidal anti-inflammatory drugs. Gut. 1995 Aug;37(2):191-4.