Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia

Ventsislava Pencheva; Daniela Petrova; Diyan Genov; Ognian Georgiev

doi:doi:10.11648/j.sjcm.20140305.14

| Peer-Reviewed

Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia

Ventsislava Pencheva, Daniela Petrova, Diyan Genov, Ognian Georgiev

Published in Science Journal of Clinical Medicine (Volume 3, Issue 5)

Received: 18 September 2014 Accepted: 5 October 2014 Published: 20 October 2014

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective: To establish the frequency of Acute Respiratory Distress Syndrome in kidney transplant patients with pneumonia and to define the risk factors associated with its development. Material and Methods: 81 kidney transplant patients hospitalized with pneumonia for the period of three years were studied. All the recipients were observed for the development of Acute Respiratory Distress Syndrome. Different noninvasive and invasive diagnostic tests were used. Results: 15 of the patients with pneumonia developed ARDS. The factors associated with increased risk for the development of Acute Respiratory Distress Syndrome included pneumonia in 1-6 month after transplantation, increased level of C – reactive protein, Cytomegalovirus-infection, bilateral lung infiltrates and failure of initial antibiotic therapy. Conclusions: The risk factors can be used to identify patients with pneumonia at increased risk for development of Acute Respiratory Distress Syndrome. Strict monitoring of high-risk patients can reduce the morbidity and mortality after renal transplantation.

Published in	Science Journal of Clinical Medicine (Volume 3, Issue 5)
DOI	10.11648/j.sjcm.20140305.14
Page(s)	98-103
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Recipient, Transplantation, Pneumonia, ARDS

References

[1]	Candan S, Pirat A, Varol G, Torgay A, Zeyneloglu P, Arslan G Respiratory problems in renal transplant recipients admitted to intensive care during long-term follow-up. Transplant Proc 2006, 38 1354-1356.
[2]	Canet E., Osman D., Lambert J., Guitton C., Heng A., Argaud L., Klouche K., Mourad G., Legendre C., Timsit J.et al. Acute respiratory failure in kidney transplant recipients a multicenter study. Critical Care 2011, 15(2) R91
[3]	Donahoe M. Acute respiratory distress syndrome A clinical review. Pulm Circ 2011;1 192-211
[4]	Bello G, De Pascale G, Antonelli M. Noninvasive ventilation for the immunocompromised patient always appropriate? Curr Opin Crit Care. 2012; 18(1) 54-60.
[5]	Kothe H., Dalhoff K. Pneumonia in the immunocompromised patient. Eur Respir Mon, 2006, 36, 200–213.
[6]	Namendys-Silva SA, Hernández-Garay M, Herrera-Gómez A. Noninvasive ventilation in immunosuppressed patients. Am J Hosp Palliat Care. 2010;27(2) 134-8
[7]	Antonelli M, Conti G, Bufi M, Costa MG, Lappa A, Rocco M, Gasparetto A, Meduri GU. Noninvasive ventilation for treatment of acute respiratory failure in patients under-going solid organ transplantation a randomized trial. JAMA 2000; 283 2239–2240
[8]	Garpestad E, Brennan J, Hill NS. Noninvasive ventilation for critical care. CHEST 2007; 132 711–720
[9]	Shorr, A; Abbott, KC; Agadoa LY. Acute respiratory distress syndrome after kidney transplantation Epidemiology, risk factors, and outcomes. Critical Care Medicine. 2003; 31 (5) 1325-1330
[10]	Sun Q., Liu Z.-H., Chen J., Ji S., Tang Z., Cheng Z., Ji D., Li L.S. An aggressive systematic strategy for acute respiratory distress syndrome caused by severe pneumonia after renal transplantation. Transplant International, 2006, 19 110–116.
[11]	ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome the Berlin Definition. JAMA. 2012;307(23) 2526-33
[12]	Bauer T. T., Ewig S., Rodloff A. C., Müller E. E., “Acute respiratory distress syndrome and pneumonia a comprehensive review of clinical data,” Clin Infect Dis. 2006; 43 (6) 748-756
[13]	Tarun G., Viswanathan S., Karnam A., Abraham G. “Etiology and Outcomes of ARDS in a Rural-Urban Fringe Hospital of South India,” Critical Care Research and Practice, vol. 2014, Article ID 181593, 7 pages, 2014
[14]	Mandell LA, Bartlett JG, Dowell SF, File TM Jr, Musher DM, Whitney C. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 2003; 37 1405-33.
[15]	Estenssoro E, Dubin A, Laffaire E, Canales H, Sáenz G, Moseinco M, Pozo M, Gómez A, Baredes N, Jannello G, Osatnik J. Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome. Crit Care Med 2002; 30 2450-6.
[16]	Valta P, Uusaro A, Nunes S, Ruokonen E, Takala J. Acute respiratory distress syndrome frequency, clinical course, and costs of care. Crit Care Med 1999; 27 2367-74.
[17]	Gauthier GM, Safdar N, Klein BS, Andes DR. Blastomycosis in solid organ transplant recipients. Transpl Infect Dis. 2007; 9 310–7.
[18]	Bastarache J.A., Blackwell TS. Development of animal models for the acute respiratory distress syndrome. Disease models & mechanisms, 2009, 2.5-6 218-223.
[19]	Matthay MA, Zemans RL.The Acute Respiratory Distress Syndrome Pathogenesis and Treatment. Annu Rev Pathol. 2011; 6 147–163.
[20]	Matthay M.A., Ware L.B., Zimmerman G.A. The acute respiratory distress syndrome. J Clin Invest. 2012; 122(8) 2731–2740.
[21]	Feltracco P., Carollo C., Barbieri S., Pettenuzzo T., Ori C. Early respiratory complications after liver transplantation World J Gastroenterol. Dec 28, 2013; 19(48) 9271–9281.
[22]	Speich R., Bij W. Epidemiology and Management of Infections after Lung Transplantation Clin Infect Dis. 2001; 33 (Supplement 1) S58-S65.
[23]	Grim SA, Clark NM Management of infectious complications in solid-organ transplant recipients. Clin Pharmacol 2011; 90 333-342
[24]	Gui P.,Luo Z.,Zeng J.,Yan C.,Li F.,Huang Z.,Yang J.,Xiao H.,Wu K. Treatment and characteristics of acute respiratory distress syndrome caused by pulmonary infection after renal transplantation. Chinese Journal of Infection Control. 2012-02
[25]	Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006; 27 337–349
[26]	Rice TW, Bernard GR. Acute lung injury and the acute respiratory distress syndrome challenges in clinical trial design. Clin Chest Med. 2006; 27 733–754.
[27]	Bajwa EK, Khan UA, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Plasma C-reactive protein levels are associated with improved outcome in ARDS. Chest 2009. 136 471–480.
[28]	Zhang Z, Ni H. C-reactive protein as a predictor of mortality in critically ill patients a meta-analysis and systematic review. Anaesthesia and Intensive Care. 2011; 39(5) 854–861.
[29]	Hillas G, Vassilakopoulos T, Plantza P, Rasidakis A, Bakakos P. C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia. European Respiratory Journal. 2010; 35(4) 805–811.
[30]	Coelho L, Póvoa P, Almeida E, Fernandes A., Mealha R., Moreira P., Sabino H. Usefulness of C-reactive protein in monitoring the severe community-acquired pneumonia clinical course. Critical Care. 2007; 11 p. R92.
[31]	Coelho LM, Salluh JI, Soares M, Bozza FA., Verdeal JCR., Castro- Faria- Neto HC., Silva JRLE., Bozza PT, Povoa P. Patterns of C-reactive protein ratio response in severe community-acquired pneumonia a cohort study. Critical Care. 2012; 16 p. R53.
[32]	Mei S., Yao W., Zhu Y., Zhao J. Protection of Pirfenidone against an Early Phase of Oleic Acid-Induced Acute Lung Injury in Rats. J Pharmacol Exp Ther. 2005, 313 (1) 379-88
[33]	Gunning K. Pathophysiology of Respiratory Failure and Indications for Respiratory Support. Surgery 2003; 21(3) 72-6
[34]	Papazian L, Doddoli C, Chetaille B, Gernez Y, Thirion X, Roch A, Donati Y, Bonnety M, Zandotti C, Thomas P A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients. Crit Care Med 2007, 35(3) 755-762.
[35]	Papazian L, Thomas P, Bregeon F, Garbe L, Zandotti C, Saux P, Gaillat F, Drancourt M, Auffray JP, Gouin F Open-lung biopsy in patients with acute respiratory distress syndrome. Anesthesiology 1998, 88(4) 935-944.
[36]	Papazian L, Fraisse A, Garbe L, Zandotti C, Thomas P, Saux P, Pierrin G, Gouin F Cytomegalovirus. An unexpected cause of ventilator-associated pneumonia. Anesthesiology 1996, 84(2) 280-287.
[37]	Osawa R. Singh N. Cytomegalovirus infection in critically ill patients a systematic review. Critical Care 2009, 13 R68
[38]	Luyt CE, Combes A., Trouillet JL, Nieszkowska A., Chastre J. Virus-induced acute respiratory distress syndrome epidemiology, management and outcome. Presse Med. 2011; 40(12) 561-8
[39]	Kojicic M., Li G., Gajic O. Acute respiratory distress syndrome in patients with Legionella pneumonia. Acta Medica Academica 2011;40(1) 39-44
[40]	Aliberti S., Brambilla A., Chalmers JD, Cilloniz C., Ramirez J., Bignamini A., Prina E, Polverino E, Tarsia P, Pesci A, Torres A, Blasi F, Cosentini R. Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis. Respiratory Research 2014, 15 27
[41]	Rello J.Importance of appropriate initial antibiotic therapy and de-escalation in the treatment of nosocomial pneumonia Eur Respir Rev 2007; 16 103, 33–39
[42]	Depuydt PO, Vandijck DM, Bekaert MA, Decruyenaere JM, Blot SI, Vogelaers DP, Benoit DD. Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia. Crit Care Med. 2008;12 R142
[43]	Kojicic M, Li G, Hanson AC, Lee KM, Thakur L, Vedre J, Ahmed A, Baddour LM, Ryu JH, Gajic O. Risk factors for the development of acute lung injury in patients with infectious pneumonia. Critical Care 2012, 16 R46
[44]	Torres A, Ewig S, Lode H, Carlet J. Defining, treating and preventing hospital acquired pneumonia European perspective. Intensive Care Med 2009; 35 9-29.
[45]	Mandell LA,Wunderink RG, Anzueto A, Bartlett JG., Campbell GD, Dean NC. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults Clin Infect Dis. 2007, 44 (Supplement 2) S27-S72.
[46]	Venditti M, Falcone M, Corrao S, Licata G, Serra P. Outcomes of patients hospitalized with community-acquired, health care-associated, and hospital-acquired pneumonia. Ann Intern Med 2009; 150 19–26.

Cite This Article

Plain Text BibTeX RIS

APA Style

Ventsislava Pencheva, Daniela Petrova, Diyan Genov, Ognian Georgiev. (2014). Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Science Journal of Clinical Medicine, 3(5), 98-103. https://doi.org/10.11648/j.sjcm.20140305.14

Copy | Download

ACS Style

Ventsislava Pencheva; Daniela Petrova; Diyan Genov; Ognian Georgiev. Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Sci. J. Clin. Med. 2014, 3(5), 98-103. doi: 10.11648/j.sjcm.20140305.14

Copy | Download

AMA Style

Ventsislava Pencheva, Daniela Petrova, Diyan Genov, Ognian Georgiev. Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Sci J Clin Med. 2014;3(5):98-103. doi: 10.11648/j.sjcm.20140305.14

Copy | Download

@article{10.11648/j.sjcm.20140305.14,
  author = {Ventsislava Pencheva and Daniela Petrova and Diyan Genov and Ognian Georgiev},
  title = {Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia},
  journal = {Science Journal of Clinical Medicine},
  volume = {3},
  number = {5},
  pages = {98-103},
  doi = {10.11648/j.sjcm.20140305.14},
  url = {https://doi.org/10.11648/j.sjcm.20140305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20140305.14},
  abstract = {Objective: To establish the frequency of Acute Respiratory Distress Syndrome in kidney transplant patients with pneumonia and to define the risk factors associated with its development. Material and Methods: 81 kidney transplant patients hospitalized with pneumonia for the period of three years were studied. All the recipients were observed for the development of Acute Respiratory Distress Syndrome. Different noninvasive and invasive diagnostic tests were used. Results: 15 of the patients with pneumonia developed ARDS. The factors associated with increased risk for the development of Acute Respiratory Distress Syndrome included pneumonia in 1-6 month after transplantation, increased level of C – reactive protein, Cytomegalovirus-infection, bilateral lung infiltrates and failure of initial antibiotic therapy. Conclusions: The risk factors can be used to identify patients with pneumonia at increased risk for development of Acute Respiratory Distress Syndrome. Strict monitoring of high-risk patients can reduce the morbidity and mortality after renal transplantation.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia
AU  - Ventsislava Pencheva
AU  - Daniela Petrova
AU  - Diyan Genov
AU  - Ognian Georgiev
Y1  - 2014/10/20
PY  - 2014
N1  - https://doi.org/10.11648/j.sjcm.20140305.14
DO  - 10.11648/j.sjcm.20140305.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 98
EP  - 103
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20140305.14
AB  - Objective: To establish the frequency of Acute Respiratory Distress Syndrome in kidney transplant patients with pneumonia and to define the risk factors associated with its development. Material and Methods: 81 kidney transplant patients hospitalized with pneumonia for the period of three years were studied. All the recipients were observed for the development of Acute Respiratory Distress Syndrome. Different noninvasive and invasive diagnostic tests were used. Results: 15 of the patients with pneumonia developed ARDS. The factors associated with increased risk for the development of Acute Respiratory Distress Syndrome included pneumonia in 1-6 month after transplantation, increased level of C – reactive protein, Cytomegalovirus-infection, bilateral lung infiltrates and failure of initial antibiotic therapy. Conclusions: The risk factors can be used to identify patients with pneumonia at increased risk for development of Acute Respiratory Distress Syndrome. Strict monitoring of high-risk patients can reduce the morbidity and mortality after renal transplantation.
VL  - 3
IS  - 5
ER  -

Copy | Download

Author Information

Ventsislava Pencheva

Department of Propedeutic of Internal Diseases, UMHAT “Alexandrovska”, Medical University, Sofia, Bulgaria
Daniela Petrova

Department of Propedeutic of Internal Diseases, UMHAT “Alexandrovska”, Medical University, Sofia, Bulgaria
Diyan Genov

Clinic of Nephrology and Transplantation, UMHAT “Alexandrovska”, Medical University, Sofia, Bulgaria
Ognian Georgiev

Department of Propedeutic of Internal Diseases, UMHAT “Alexandrovska”, Medical University, Sofia, Bulgaria

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Ventsislava Pencheva, Daniela Petrova, Diyan Genov, Ognian Georgiev. (2014). Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Science Journal of Clinical Medicine, 3(5), 98-103. https://doi.org/10.11648/j.sjcm.20140305.14

Copy | Download

ACS Style

Ventsislava Pencheva; Daniela Petrova; Diyan Genov; Ognian Georgiev. Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Sci. J. Clin. Med. 2014, 3(5), 98-103. doi: 10.11648/j.sjcm.20140305.14

Copy | Download

AMA Style

Ventsislava Pencheva, Daniela Petrova, Diyan Genov, Ognian Georgiev. Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia. Sci J Clin Med. 2014;3(5):98-103. doi: 10.11648/j.sjcm.20140305.14

Copy | Download

@article{10.11648/j.sjcm.20140305.14,
  author = {Ventsislava Pencheva and Daniela Petrova and Diyan Genov and Ognian Georgiev},
  title = {Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia},
  journal = {Science Journal of Clinical Medicine},
  volume = {3},
  number = {5},
  pages = {98-103},
  doi = {10.11648/j.sjcm.20140305.14},
  url = {https://doi.org/10.11648/j.sjcm.20140305.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20140305.14},
  abstract = {Objective: To establish the frequency of Acute Respiratory Distress Syndrome in kidney transplant patients with pneumonia and to define the risk factors associated with its development. Material and Methods: 81 kidney transplant patients hospitalized with pneumonia for the period of three years were studied. All the recipients were observed for the development of Acute Respiratory Distress Syndrome. Different noninvasive and invasive diagnostic tests were used. Results: 15 of the patients with pneumonia developed ARDS. The factors associated with increased risk for the development of Acute Respiratory Distress Syndrome included pneumonia in 1-6 month after transplantation, increased level of C – reactive protein, Cytomegalovirus-infection, bilateral lung infiltrates and failure of initial antibiotic therapy. Conclusions: The risk factors can be used to identify patients with pneumonia at increased risk for development of Acute Respiratory Distress Syndrome. Strict monitoring of high-risk patients can reduce the morbidity and mortality after renal transplantation.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Acute Respiratory Distress Syndrome in Renal Transplant Patients with Pneumonia
AU  - Ventsislava Pencheva
AU  - Daniela Petrova
AU  - Diyan Genov
AU  - Ognian Georgiev
Y1  - 2014/10/20
PY  - 2014
N1  - https://doi.org/10.11648/j.sjcm.20140305.14
DO  - 10.11648/j.sjcm.20140305.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 98
EP  - 103
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20140305.14
AB  - Objective: To establish the frequency of Acute Respiratory Distress Syndrome in kidney transplant patients with pneumonia and to define the risk factors associated with its development. Material and Methods: 81 kidney transplant patients hospitalized with pneumonia for the period of three years were studied. All the recipients were observed for the development of Acute Respiratory Distress Syndrome. Different noninvasive and invasive diagnostic tests were used. Results: 15 of the patients with pneumonia developed ARDS. The factors associated with increased risk for the development of Acute Respiratory Distress Syndrome included pneumonia in 1-6 month after transplantation, increased level of C – reactive protein, Cytomegalovirus-infection, bilateral lung infiltrates and failure of initial antibiotic therapy. Conclusions: The risk factors can be used to identify patients with pneumonia at increased risk for development of Acute Respiratory Distress Syndrome. Strict monitoring of high-risk patients can reduce the morbidity and mortality after renal transplantation.
VL  - 3
IS  - 5
ER  -

Copy | Download