Papular Cutaneous Amyloidosis Associated with Multiple Myeloma

Al-Raddadi Reem; Abbaspour Valiollah; Ndiaye Maodo

doi:doi:10.11648/j.sjcm.20160502.11

| Peer-Reviewed

Papular Cutaneous Amyloidosis Associated with Multiple Myeloma

Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo

Published in Science Journal of Clinical Medicine (Volume 5, Issue 2)

Received: 23 January 2016 Accepted: 24 February 2016 Published: 4 March 2016

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.

Published in	Science Journal of Clinical Medicine (Volume 5, Issue 2)
DOI	10.11648/j.sjcm.20160502.11
Page(s)	16-19
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Amyloidosis, Papular, Multiple Myeloma

References

[1]	Hawkins PN. Amyloidosis. Blood Rev.1988; 2(4): 270-280.
[2]	Westermark P, Benson MD, Buxbaum JN, et al. A primer of amyloid nomenclature. Amyloid. 2007; 14(3): 179-183.
[3]	Jaccard A, Desport E, D. Mohty, Bridoux F. Amylose AL. Rev Med Int. 2015; 36: 89–97.
[4]	Wong CK. Mucocutaneous manifestations in systemic amyloidosis. Clin Dermatol. 1990; 8: 7-12.
[5]	López L, González K, Navarrete G, Novales J, Guarneros A, Cortés B, et al. Multiple myeloma and systemic amyloidosis. Int J Dermatol. 2008; 47: 165-7.
[6]	Oliveira Ederson Valei Lopes de, Pozetti Ana Carolina Garcia, Pozetti Eurides Maria de Oliveira, Antonio João Roberto, Michalany Nilceo Schwery. Primary systemic amyloidosis associated with multiple myeloma. An. Bras. Dermatol. 2012; 87: 119-122.
[7]	Desport E, Bridoux F, Sirac C, et al. AL Amyloidosis. Orphanet Journal of Rare Diseases. 2012; 7: 54. doi: 10.1186/1750-1172-7-54.
[8]	Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003; 349: 583–596. doi: 10.1056/NEJMra023144.
[9]	Serpell L C, Sunde M, Benson M D, Tennent GA, Pepys M. B, Fraser P E. The protofilament substructure of amyloid fibrils. J Mol Biol. 2000; 300: 1033–1039.
[10]	Sunde M, Serpell L C, Bartlam M, Fraser P E, Pepys M B, Blake C C. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J Mol Biol.1997; 273: 729–739.
[11]	Modiano P. Amyloses cutanées. Encycl Méd Chir, Dermatologie. 2003; 10: 98-720.
[12]	Silverstein SR. Primary systemic amyloidosis and the dermatologist where classic skin lesions may provide the clue for early diagnosis. Dermatol Online J. 2005; 11: 5.
[13]	Robert C, Aractingi S, Prost C, Verola O, Blanchet-Bardon C, Blanc F et al. Bullous amyloidosis. Report of 3 cases and review of the literature. Medicine. 1993; 72: 38-44.
[14]	Fujita Y, Tsuji-Aben Y, Sato-Matsumura K C, Akiyama M, & Shimizu H. Nail dystrophy and blisters as sole manifestations in myeloma-associated amyloidosis. Journal of American Academy of Dermatology. 2006; 54: 712-714.
[15]	Cholez C, Cuny J F, Pouaha J, Thomas P, Tromp G, Truchet F. Atteinte unguéale et infiltration sclérodermiforme du visage au cours d’une amylose systémique. Ann Dermatol Venereol. 2005; 132: 252–254.
[16]	Robert C, Aractingi S, Prost C, Verola O, Blanchet-Bardon C, Blanc F et al. Bullous amyloidosis. Report of 3 cases and review of the litterature. Medicine 1993; 72: 38-44.
[17]	Moumas E, Bridoux F, Desport E. Nephropathie amyloide AL: données cliniques, épidémiologiques et pronostiques d’une série de 41 patients. Nephrol Ther. 2009; 5: 371.

Cite This Article

Plain Text BibTeX RIS

APA Style

Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. (2016). Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Science Journal of Clinical Medicine, 5(2), 16-19. https://doi.org/10.11648/j.sjcm.20160502.11

Copy | Download

ACS Style

Al-Raddadi Reem; Abbaspour Valiollah; Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci. J. Clin. Med. 2016, 5(2), 16-19. doi: 10.11648/j.sjcm.20160502.11

Copy | Download

AMA Style

Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci J Clin Med. 2016;5(2):16-19. doi: 10.11648/j.sjcm.20160502.11

Copy | Download

@article{10.11648/j.sjcm.20160502.11,
  author = {Al-Raddadi Reem and Abbaspour Valiollah and Ndiaye Maodo},
  title = {Papular Cutaneous Amyloidosis Associated with Multiple Myeloma},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {2},
  pages = {16-19},
  doi = {10.11648/j.sjcm.20160502.11},
  url = {https://doi.org/10.11648/j.sjcm.20160502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20160502.11},
  abstract = {We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Papular Cutaneous Amyloidosis Associated with Multiple Myeloma
AU  - Al-Raddadi Reem
AU  - Abbaspour Valiollah
AU  - Ndiaye Maodo
Y1  - 2016/03/04
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.20160502.11
DO  - 10.11648/j.sjcm.20160502.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 16
EP  - 19
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20160502.11
AB  - We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.
VL  - 5
IS  - 2
ER  -

Copy | Download

Author Information

Al-Raddadi Reem

Department of Dermatology, Saint Louis Hospital, University Paris 13, Paris, France
Abbaspour Valiollah

Department of Dermatology, Aristide Le Dantec Hospital, University Cheikh Anta DIOP of Dakar, Senegal BP 3001, Dakar, Senegal
Ndiaye Maodo

Department of Dermatology, Aristide Le Dantec Hospital, University Cheikh Anta DIOP of Dakar, Senegal BP 3001, Dakar, Senegal

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. (2016). Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Science Journal of Clinical Medicine, 5(2), 16-19. https://doi.org/10.11648/j.sjcm.20160502.11

Copy | Download

ACS Style

Al-Raddadi Reem; Abbaspour Valiollah; Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci. J. Clin. Med. 2016, 5(2), 16-19. doi: 10.11648/j.sjcm.20160502.11

Copy | Download

AMA Style

Al-Raddadi Reem, Abbaspour Valiollah, Ndiaye Maodo. Papular Cutaneous Amyloidosis Associated with Multiple Myeloma. Sci J Clin Med. 2016;5(2):16-19. doi: 10.11648/j.sjcm.20160502.11

Copy | Download

@article{10.11648/j.sjcm.20160502.11,
  author = {Al-Raddadi Reem and Abbaspour Valiollah and Ndiaye Maodo},
  title = {Papular Cutaneous Amyloidosis Associated with Multiple Myeloma},
  journal = {Science Journal of Clinical Medicine},
  volume = {5},
  number = {2},
  pages = {16-19},
  doi = {10.11648/j.sjcm.20160502.11},
  url = {https://doi.org/10.11648/j.sjcm.20160502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20160502.11},
  abstract = {We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Papular Cutaneous Amyloidosis Associated with Multiple Myeloma
AU  - Al-Raddadi Reem
AU  - Abbaspour Valiollah
AU  - Ndiaye Maodo
Y1  - 2016/03/04
PY  - 2016
N1  - https://doi.org/10.11648/j.sjcm.20160502.11
DO  - 10.11648/j.sjcm.20160502.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 16
EP  - 19
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20160502.11
AB  - We report a case of papular cutaneous amyloidosis associated with multiple myeloma in a 52 years old man who presented papular xanthoma like lesions in periorbital areas and scrotum with severe bone pain in thoracic and lumbar spinal column and lower limbs. Cutaneous histopathology revealed the presence of amorphous deposits in papillary dermis surrounded with small lymphoid infiltrates with erythrocyte containing slots. Congo red staining was positive and bone marrow aspiration showed dysplastic plasma cells. Lytic lesions were observed in long bones and skull radiography. 24 hours Proteinuria was 3.69 g / l. A combination of Melphalan and prednisone as treatment could restore renal function without any change in skin lesions after 14 months.
VL  - 5
IS  - 2
ER  -

Copy | Download