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Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina
Science Journal of Clinical Medicine
Volume 6, Issue 1, January 2017, Pages: 20-23
Received: Feb. 12, 2017; Accepted: Mar. 4, 2017; Published: Mar. 21, 2017
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Weiting Wang, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Chunhua Hao, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Zhuanyou Zhao, State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
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Aim To study the antiplatelet aggregation of ticlopidine (TC). Methods Using coronary artery Folts, model in beagles, the efficacy of TC on platelet aggregation was studied. Results (1)TC16, 32 mg•kg-1 dramatically inhibited the frequency of CFRs dose-dependently, and the times of CFRs decreased by 27%, 56%, 95%, 100% respectively at 1-4 h than that in control group’s after TC 32 mg•kg-1 administration. CFRs were abolished and did not return when AD was infused after TC 32 mg•kg-1 administration. (2)The time for CFRs absolute disappearance of TC in dose of 32 mg•kg-1 was shorter than that in control group. (3)The platelet aggregation induced by ADP was inhibited obviously after TC 16,32 mg•kg-1 administration, and the aggregation in TC 32 mg•kg-1 didn’t return after AD administration. Conclusion TC had dose-dependent antiplatelet effects in beagles, suggesting TC has reliable therapeutical efficacy on angina pectoris.
Ticlopidine, Antiplatelet Aggregation, Unstable Angina Pectoris
To cite this article
Weiting Wang, Chunhua Hao, Zhuanyou Zhao, Effects of Ticlopidine on Platelet Aggregation in Beagles with Unstable Angina, Science Journal of Clinical Medicine. Vol. 6, No. 1, 2017, pp. 20-23. doi: 10.11648/j.sjcm.20170601.12
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