Science Journal of Clinical Medicine

| Peer-Reviewed |

Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis

Received: 15 April 2018    Accepted: 02 May 2018    Published: 28 May 2018
Views:       Downloads:

Share This Article

Abstract

Background: Osteoarthritis (OA) is a degenerative, common and progressive inflammatory joint disease starting with disruption and corrosion of articular cartilage. Polypharmacy can be considered as use of multiple drugs. Objective: To investigate the correlation between polypharmacy for patients with symptomatic knee osteoarthritis and their function, pain, daily life activities and quality of life. Method: Fifty patients, diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) classification criteria, were included in this study. Patient’s demographic data, height, weight, body mass index, knee pain duration, number of painful knees, drugs used for treatment of comorbid diseases and knee osteoarthritis as well as drugs used for other diseases were recorded. Using 5 or more drugs were regarded as polypharmacy in this study. Characteristics of patients with polypharmacy were compared to those without polypharmacy. Kellgren-Lawrence Classification was used for radiological grading of knee osteoarthritis of the patients. Knee osteoarthritis related symptoms and functional state were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS). Mini Mental State Examination (MMSE) was used for identifying the cognitive level. Result: Mean age of the patients included in the study was 64±13.7 years. 35 patients (70%) were female. Mean body mass index was 30.6±4.2 kg/m2. Mean knee pain duration was 4.9±3.8 years. 30 patients (60%) had bilateral knee involvement. Twenty-one patient (42%) had polypharmacy. While NSAIDs is the most frequently used drug, the most frequently observed comorbidity was hypertension. Kellgren Lawrence grade was significantly (p ˂ 0.05) higher in the group with polypharmacy than the group without polypharmacy. KOOS symptoms, pain, function-daily life, sport recreational acts, quality of life and total score and MMS total score were significantly (p ˂ 0.05) lower in the group with polypharmacy than the group without polypharmacy. Discussion: It has been observed that polypharmacy affects the functional state and quality of life negatively in patients with knee osteoarthritis. Conclusion: Attention must be paid to the training activities raising awareness for appropriate drug use, and awareness of the physicians as well as elderly people regarding the polypharmacy must be expanded.

DOI 10.11648/j.sjcm.20180703.11
Published in Science Journal of Clinical Medicine (Volume 7, Issue 3, May 2018)
Page(s) 25-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Polypharmacy, Osteoarthritis, Functional State

References
[1] Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, Mcgowan J, Tugwell P. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis care & research. 2012; 64(4): 465-474.
[2] Hawker GA, Mian S, Bednis K, Stanaitis I. Osteoarthritis year 2010 in review: non-pharmacologic therapy. Osteoarthritis Cartilage. 2011; 19: 366-374.
[3] Kaufman KR, Hughes C, Morrey BF Morrey M, Ann KN. Gait characteristics of patients with knee osteoarthritis. J Biomech. 2001; 34(7): 907-915.
[4] Jordan JM, Hochberg MC, Silman, AJ, Smolen JS, Weinblatt MR, Weisman MH. Epidemiology and classification of osteoarthritis. Rheumatology. 4th ed. Spain: Mosby Elsevier. 2008:1691-701.
[5] Arslan S, Atalay A, Gökçe Kutsal Y. Yaşlılarda ilaç tüketimi (Drug use in elderly) Turk J Geriatr. 2000; 3: 56-60.
[6] Yıldırım AB, Kılınc AY. Yaşlı hastalarda polifarmasi ve ilaç etkileşimi. Turk Kardiyol Dern Ars, 2017; 45.5: 17-21.
[7] Viktil KK, Blix HS, Moger TA, Reikvam A. Polypharmacy as commonly definedis an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol. 2007; 63: 187–195.
[8] Rochon PA, Schmader KE, Sokol HN. Drug prescribing for older adults. Uptodate 2012.
[9] Mamun K, Lien CTC, Goh-Tan CYE. Polypharmacy and inappropriate medication use in Singapore nursing homes. Ann Acad Med Singapore.2004; 33: 49-52.
[10] Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16: 494-502.
[11] Roos EM, Lohmander LS. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health and quality of life outcomes.2003;1.1: 64.
[12] Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi. 2002; 13: 273-281.
[13] Ramage-Morin PL. Medication use among senior Canadians. Health Rep. 2009; 20: 37–44
[14] Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, Lindau ST. Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA. 2008; 300:2867–2878.
[15] Kutsal YG. Yaslılarda çoklu ilaç kullanımı (Polypharmacy in elderly). Turk J Geriatr. 2006; Özel Sayı: 37-44.
[16] Hanken JT, Fillenbaum GG, Studenski SA, et al. Factors associated with suboptimal analgesic use in community-dwelling elderly. Ann Pharmacother. 1996; 30: 739-744.
[17] Tuncer T, Cay, HF, Kacar C, Altan L, Atik OS, Aydin AT, et al. Evidence-based recommendations for the management of knee osteoarthritis: a consensus report of the Turkish League Against Rheumatism. Turk J Rheumatol. 2012;27(1): 1-17
[18] Ozturk Z. Yaşlı hastalarda ilaç kullanımı ve polifarmasi. Tepecik Eğit. ve Araşt. Hast. Dergisi. 2017; 27(2): 103-108
[19] Novaes PH, da Cruz DT, Lucchetti ALG, Leite ICG, Lucchetti G. The “iatrogenic triad”: polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults. Int J Clin Pharm. 2017; 39(4):818–25.
[20] Orwig D, Brandt N, Gruber-Baldini AL. Medication management assessment for older adults in the community. The Gerontologist. 2006; 46(5):661-668.
Author Information
  • Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Education Research Hospital, Istanbul, Turkey

  • Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Education Research Hospital, Istanbul, Turkey

Cite This Article
  • APA Style

    Goksen Goksenoglu, Mustafa Aziz Yildirim. (2018). Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis. Science Journal of Clinical Medicine, 7(3), 25-29. https://doi.org/10.11648/j.sjcm.20180703.11

    Copy | Download

    ACS Style

    Goksen Goksenoglu; Mustafa Aziz Yildirim. Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis. Sci. J. Clin. Med. 2018, 7(3), 25-29. doi: 10.11648/j.sjcm.20180703.11

    Copy | Download

    AMA Style

    Goksen Goksenoglu, Mustafa Aziz Yildirim. Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis. Sci J Clin Med. 2018;7(3):25-29. doi: 10.11648/j.sjcm.20180703.11

    Copy | Download

  • @article{10.11648/j.sjcm.20180703.11,
      author = {Goksen Goksenoglu and Mustafa Aziz Yildirim},
      title = {Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis},
      journal = {Science Journal of Clinical Medicine},
      volume = {7},
      number = {3},
      pages = {25-29},
      doi = {10.11648/j.sjcm.20180703.11},
      url = {https://doi.org/10.11648/j.sjcm.20180703.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjcm.20180703.11},
      abstract = {Background: Osteoarthritis (OA) is a degenerative, common and progressive inflammatory joint disease starting with disruption and corrosion of articular cartilage. Polypharmacy can be considered as use of multiple drugs. Objective: To investigate the correlation between polypharmacy for patients with symptomatic knee osteoarthritis and their function, pain, daily life activities and quality of life. Method: Fifty patients, diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) classification criteria, were included in this study. Patient’s demographic data, height, weight, body mass index, knee pain duration, number of painful knees, drugs used for treatment of comorbid diseases and knee osteoarthritis as well as drugs used for other diseases were recorded. Using 5 or more drugs were regarded as polypharmacy in this study. Characteristics of patients with polypharmacy were compared to those without polypharmacy. Kellgren-Lawrence Classification was used for radiological grading of knee osteoarthritis of the patients. Knee osteoarthritis related symptoms and functional state were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS). Mini Mental State Examination (MMSE) was used for identifying the cognitive level. Result: Mean age of the patients included in the study was 64±13.7 years. 35 patients (70%) were female. Mean body mass index was 30.6±4.2 kg/m2. Mean knee pain duration was 4.9±3.8 years. 30 patients (60%) had bilateral knee involvement. Twenty-one patient (42%) had polypharmacy. While NSAIDs is the most frequently used drug, the most frequently observed comorbidity was hypertension. Kellgren Lawrence grade was significantly (p ˂ 0.05) higher in the group with polypharmacy than the group without polypharmacy. KOOS symptoms, pain, function-daily life, sport recreational acts, quality of life and total score and MMS total score were significantly (p ˂ 0.05) lower in the group with polypharmacy than the group without polypharmacy. Discussion: It has been observed that polypharmacy affects the functional state and quality of life negatively in patients with knee osteoarthritis. Conclusion: Attention must be paid to the training activities raising awareness for appropriate drug use, and awareness of the physicians as well as elderly people regarding the polypharmacy must be expanded.},
     year = {2018}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Impact of Polypharmacy on Functional State in Patients with Symptomatic Knee Osteoarthritis
    AU  - Goksen Goksenoglu
    AU  - Mustafa Aziz Yildirim
    Y1  - 2018/05/28
    PY  - 2018
    N1  - https://doi.org/10.11648/j.sjcm.20180703.11
    DO  - 10.11648/j.sjcm.20180703.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 25
    EP  - 29
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.20180703.11
    AB  - Background: Osteoarthritis (OA) is a degenerative, common and progressive inflammatory joint disease starting with disruption and corrosion of articular cartilage. Polypharmacy can be considered as use of multiple drugs. Objective: To investigate the correlation between polypharmacy for patients with symptomatic knee osteoarthritis and their function, pain, daily life activities and quality of life. Method: Fifty patients, diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) classification criteria, were included in this study. Patient’s demographic data, height, weight, body mass index, knee pain duration, number of painful knees, drugs used for treatment of comorbid diseases and knee osteoarthritis as well as drugs used for other diseases were recorded. Using 5 or more drugs were regarded as polypharmacy in this study. Characteristics of patients with polypharmacy were compared to those without polypharmacy. Kellgren-Lawrence Classification was used for radiological grading of knee osteoarthritis of the patients. Knee osteoarthritis related symptoms and functional state were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS). Mini Mental State Examination (MMSE) was used for identifying the cognitive level. Result: Mean age of the patients included in the study was 64±13.7 years. 35 patients (70%) were female. Mean body mass index was 30.6±4.2 kg/m2. Mean knee pain duration was 4.9±3.8 years. 30 patients (60%) had bilateral knee involvement. Twenty-one patient (42%) had polypharmacy. While NSAIDs is the most frequently used drug, the most frequently observed comorbidity was hypertension. Kellgren Lawrence grade was significantly (p ˂ 0.05) higher in the group with polypharmacy than the group without polypharmacy. KOOS symptoms, pain, function-daily life, sport recreational acts, quality of life and total score and MMS total score were significantly (p ˂ 0.05) lower in the group with polypharmacy than the group without polypharmacy. Discussion: It has been observed that polypharmacy affects the functional state and quality of life negatively in patients with knee osteoarthritis. Conclusion: Attention must be paid to the training activities raising awareness for appropriate drug use, and awareness of the physicians as well as elderly people regarding the polypharmacy must be expanded.
    VL  - 7
    IS  - 3
    ER  - 

    Copy | Download

  • Sections