The Analysis of Electrolyte Levels on Hypertensive Patients in Noongan Regional General Hospital, North Sulawesi, Indonesia
Science Journal of Clinical Medicine
Volume 8, Issue 5, September 2019, Pages: 54-60
Received: Sep. 19, 2019;
Accepted: Sep. 30, 2019;
Published: Oct. 15, 2019
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Diana Shintawati Purwanto, Department of Biochemistry, Sam Ratulangi University, Manado, Indonesia
Yanti Meilen Mewo, Department of Biochemistry, Sam Ratulangi University, Manado, Indonesia
Edmond Leonard Jim, Department of Cardiovascular Medicine, Sam Ratulangi University, Manado, Indonesia
Richardo Jordan Laloan, Clinical Clerkship Program, Sam Ratulangi University, Manado, Indonesia
Joice Nancy Ansje Engka, Department of Physiology, Sam Ratulangi University, Manado, Indonesia
Billy Johnson Kepel, Department of Chemistry, Sam Ratulangi University, Manado, Indonesia
Hypertension is one of the major risk factors of cardiovascular diseases, in addition to hypercholesterolemia and diabetes mellitus. Approximately 95% cases of hypertension in Indonesia is essential hypertension that remains unknown for the etiology and tends to be multifactorial causes. Electrolyte imbalance is thought as one of the prominent underlying mechanisms of hypertension. Electrolyte imbalance can cause serious and life-threatening cardiovascular problems. This study aimed to find out the association between electrolytes levels (serum sodium, potassium, chloride, and total calcium) and blood pressure in hypertensive patients. This was a cross-sectional study that conducted on June-August 2019 at Noongan Regional General Hospital, Minahasa Regency, North Sulawesi, Indonesia. Demographic data such as age, sex, symptoms, salt diet, and consumption of antihypertensive drugs were collected, and then physical examinations including systolic and diastolic blood pressures and body mass index (BMI) were performed. One Sample Kolmogorov-Smirnov and Spearman Rank tests were used for bivariate analysis. There is significant dirrect correlation between serum sodium levels and systolic blood pressure, and an inverse relationship with diastolic blood pressure. As for potassium, there is an inverse relationship between serum potassium levels with systolic and diastolic blood pressures, but not significant. There is a direct correlation between serum chloride levels and systolic blood pressure, and an inverse relationship with diastolic pressure, but not significant. For total calcium, there is a direct correlation between serum total calcium levels and systolic and diastolic blood pressures, but not significant. In this study, we found out only sodium has a significant correlation with blood pressure, while other electrolytes have a correlation but are not significant.
Diana Shintawati Purwanto,
Yanti Meilen Mewo,
Edmond Leonard Jim,
Richardo Jordan Laloan,
Joice Nancy Ansje Engka,
Billy Johnson Kepel,
The Analysis of Electrolyte Levels on Hypertensive Patients in Noongan Regional General Hospital, North Sulawesi, Indonesia, Science Journal of Clinical Medicine.
Vol. 8, No. 5,
2019, pp. 54-60.
Egan BM. Defining Hypertension by Blood Pressure 130/80 mm Hg Leads to an Impressive Burden of Hypertension in Young and Middle–Aged Black Adults: Follow–Up in the CARDIA Study. J Am Heart Assoc. 2018; 7 (14): 1-3.
Drozdz D, Kawecka-Jaszcz K. Cardiovascular Changes During Chronic Hypertensive States. Pediatr Nephrol. 2014; 29 (9): 1507–16.
Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017; 2017: 5491838.
Tabrizi JS, Sadeghi-Bazargani H, Farahbakhsh M, Nikniaz L, Nikniaz Z. Prevalence and Associated Factors of Prehypertension and Hypertension in Iranian Population: The Lifestyle Promotion Project (LPP). PLoS One. 2016; 11 (10): e0165264.
Patnaik L, Paul KK, Pattnaik S, Sahu T. Lifestyle Pattern and Hypertension Related Knowledge, Attitude and Practices among Diagnosed Patients of Hypertension Attending a Tertiary Care Hospital. J Cardiovasc Dis Res. 2017; 8 (4): 108–111.
Diana DAIAT, Astini DAAAS. Prevalence of Hypertension Among Adults in Kintamani Subdistrict-Bali. IOP Conference Series: Materials Science and Engineering. 2018; 434: 012322.
Kementerian Kesehatan RI Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar. Prevalensi Hipertensi Berdasarkan Diagnosis Dokter atau Minum Obat Antihipertensi Pada Penduduk Umur ≥ 18 Tahun Menurut Provinsi, 2018.
Dinas Kesehatan Daerah Provinsi Sulawesi Utara. Profil Kesehatan Provinsi Sulawesi Utara 2016. Pengukuran Tekanan Darah Penduduk ≥18 Tahun Menurut Jenis Kelamin, Kabupaten/Kota Provinsi Sulawesi Utara. 2017.
Balci AK. General Characteristics of Patients with Electrolyte Imbalance Admitted to Emergency Department. World J Emerg Med. 2013; 4 (2): 113-6.
Forjaz CLM, Bartholomeu T, Rezende JAS, Oliveira JA, Basso L, Tani G, et al. Genetic and Environmental Influences on Blood Pressure and Physical Activity: A Study of Nuclear Families from Muzambinho, Brazil. Braz J Med Biol Res. 2012; 45 (12), 1269–75.
Opoku-Okrah C, Safo BK, Dogbe EE. Changes in Potassium and Sodium Concentrations in Stored Blood. Pan Afr Med J. 2015; 20: 236.
Bolívar JJ. Essential Hypertension: An Approach to Its Etiology and Neurogenic Pathophysiology. Int J Hypertens. 2013; 2013: 547809.
Lynch, R. 2018 ESC/ESH Guidelines for The Management of Hypertension. J Hypertens. 2018; 36 (10): 89.
Bell K, Twiggs J, Olin BR. Hypertension: The Silent Killer: Updated JNC-8 Guideline Recommendations. Alabama Pharmacy Association. 2015.
Ghosh S, Mukhopadhyay S, Barik A. Sex Differences in The Risk Profile of Hypertension: A Cross-Sectional Study. BMJ Open. 2016; 6 (7): e010085.
Ahmad A, Oparil S. Hypertension in Female: Recent Advances and Lingering Questions. Hypertension. 2017; 70 (1): 19–26.
Acheampong K, Nyamari JM, Ganu D, Appiah S, Pan X, Kaminga A, et al. Predictors of Hypertension among Adult Female Population in Kpone-Katamanso District, Ghana. Int J Hypertens. 2019: 1–9.
Everet B, Zajacova A. Gender Differences in Hypertension and Hypertension Awareness Among Young Adults. Biodemography Soc Biol. 2015; 61 (1): 1-17.
Courand PY, Serraille M, Girerd N, Demarquay G, Milon H, Lantelme P, et al. The Paradoxical Significance of Headache in Hypertension. Am J Hypertens, 2016; 29 (9): 1109–16.
Gupta VK. Systemic Hypertension, Headache, and Ocular Hemodynamics: A New Hypothesis. MedGenMed. 2006; 83 (3): 63.
Handler J. Headache and Hypertension: Primary or Secondary? J Clin Hypertens. 2007; 6 (1): 42-4.
Yeung A. What is The Connection Between Hypertension, Headache and Migraine? Canadian Hypertension Society. 2006; 87: 1-8.
Olack B, Wabwire-Mangen F, Smeeth L, Mongomery JM, Kiwanuka N, Breiman RF. Risk Factors of Hypertension Among Adults Aged 35-64 Years Living in Urban Slum Nairobi, Kenya. BMC Public Health, 2015; 15: 1251.
Jiang SZ, Lu W, Zong XF, Ruan HY, Liu Y. Obesity and Hypertension. Exp Ther Med. 2016; 12 (4), 2395–9.
McCallum L, Jeemon P, Hastie CE, Patel RK, Williamson C, Redzuan AM, et al. Serum Chloride Is an Independent Predictor of Mortality in Hypertensive Patients. Am Heart J. 2013; 62 (5): 836-43.
Frisoli TM, Schmieder RE, Grodzicki T, Messerli FH. Salt and Hypertension: Is Salt Dietary Reduction Worth the Effort? Am J Med. 2012; 125 (5): 433–9.
Yao Y, He L, Jin Y, Chen Y, Tang H, Song X, et al. The Relationship Between Serum Calcium Level, Blood Lipids, and Blood Pressure in Hypertensive and Normotensive Subjects who Come from a Normal University in East China. Biol Trace Elem Res. 2013; 153 (1-3): 35-40.
Khan DM, Khan IM, Randhawa FA, Shahid M. Correlation between Serum Calcium Level with Blood Pressure Level In Patients Presenting With Type 2 Diabetes Mellitus. Esculapio. 2017; 13 (1): 18-21.