Although mycosis fungoides is the most common cutaneous T-cell lymphoma, its etiopathogenesis has not been clarified definitively and there is no standard and curative treatment method. Medical records of 57 patients diagnosed with mycosis fungoides by clinical and histopathological findings were retrospectively reviewed in our clinic. Complete blood count, erythrocyte sedimentation rate, peripheral blood smear, biochemical findings, chest radiographs, and computerized tomography of all patients were reviewed; patients were staged using TNM system. The clinical presentation was classical patch/plaque form in 44patients and other forms in 13. According to TNM staging, 9patients were stage 1a, 38 were stage 1b, 5 were 2a, and 2 were stage 3, and 2 were stage 4a. The pathological findings were basal alignment of lymphocytes, reticular fibroplasia, atypical lymphocytes, and epidermotropism. Remission was achieved by topical imiquimod in 2patients, phototherapy in 30, and phototherapy and systemic treatment in 8. Remission rate with narrow band UV B was 72%, and that of psoralen UV A was 85.71%. Ten patients in remission had recurrence. Age, sex, duration of disease, and clinical presentation had no effect on remission or recurrence of mycosis fungoides. Reticular fibroplasia is a supporting histopathological finding in mycosis fungoides, together with basal alignment of lymphocytes, atypical lymphocytes and epidermotropism. Topical imiquimod treatment for local lesions and phototherapy for widespread lesions are effective, and psoralen UVA treatment seems to be more efficient than narrow band UVB.
| Published in | Science Journal of Clinical Medicine (Volume 3, Issue 4) |
| DOI | 10.11648/j.sjcm.20140304.12 |
| Page(s) | 65-69 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Mycosis Fungoides, Histopathology, Epidemiology, Remission, Recurrence
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APA Style
Ilkin Zindanci, Mukaddes Kavala, Ebru Zemheri, Emek Kocaturk, Burce Can, et al. (2014). Clinicopathological Evaluation and Outcome of Mycosis Fungoides. Science Journal of Clinical Medicine, 3(4), 65-69. https://doi.org/10.11648/j.sjcm.20140304.12
ACS Style
Ilkin Zindanci; Mukaddes Kavala; Ebru Zemheri; Emek Kocaturk; Burce Can, et al. Clinicopathological Evaluation and Outcome of Mycosis Fungoides. Sci. J. Clin. Med. 2014, 3(4), 65-69. doi: 10.11648/j.sjcm.20140304.12
AMA Style
Ilkin Zindanci, Mukaddes Kavala, Ebru Zemheri, Emek Kocaturk, Burce Can, et al. Clinicopathological Evaluation and Outcome of Mycosis Fungoides. Sci J Clin Med. 2014;3(4):65-69. doi: 10.11648/j.sjcm.20140304.12
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Download@article{10.11648/j.sjcm.20140304.12,
author = {Ilkin Zindanci and Mukaddes Kavala and Ebru Zemheri and Emek Kocaturk and Burce Can and Zafer Turkoglu and Melek Koc and Seyma Ozkanli and Filiz Topaloglu},
title = {Clinicopathological Evaluation and Outcome of Mycosis Fungoides},
journal = {Science Journal of Clinical Medicine},
volume = {3},
number = {4},
pages = {65-69},
doi = {10.11648/j.sjcm.20140304.12},
url = {https://doi.org/10.11648/j.sjcm.20140304.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20140304.12},
abstract = {Although mycosis fungoides is the most common cutaneous T-cell lymphoma, its etiopathogenesis has not been clarified definitively and there is no standard and curative treatment method. Medical records of 57 patients diagnosed with mycosis fungoides by clinical and histopathological findings were retrospectively reviewed in our clinic. Complete blood count, erythrocyte sedimentation rate, peripheral blood smear, biochemical findings, chest radiographs, and computerized tomography of all patients were reviewed; patients were staged using TNM system. The clinical presentation was classical patch/plaque form in 44patients and other forms in 13. According to TNM staging, 9patients were stage 1a, 38 were stage 1b, 5 were 2a, and 2 were stage 3, and 2 were stage 4a. The pathological findings were basal alignment of lymphocytes, reticular fibroplasia, atypical lymphocytes, and epidermotropism. Remission was achieved by topical imiquimod in 2patients, phototherapy in 30, and phototherapy and systemic treatment in 8. Remission rate with narrow band UV B was 72%, and that of psoralen UV A was 85.71%. Ten patients in remission had recurrence. Age, sex, duration of disease, and clinical presentation had no effect on remission or recurrence of mycosis fungoides. Reticular fibroplasia is a supporting histopathological finding in mycosis fungoides, together with basal alignment of lymphocytes, atypical lymphocytes and epidermotropism. Topical imiquimod treatment for local lesions and phototherapy for widespread lesions are effective, and psoralen UVA treatment seems to be more efficient than narrow band UVB.},
year = {2014}
}
TY - JOUR T1 - Clinicopathological Evaluation and Outcome of Mycosis Fungoides AU - Ilkin Zindanci AU - Mukaddes Kavala AU - Ebru Zemheri AU - Emek Kocaturk AU - Burce Can AU - Zafer Turkoglu AU - Melek Koc AU - Seyma Ozkanli AU - Filiz Topaloglu Y1 - 2014/07/20 PY - 2014 N1 - https://doi.org/10.11648/j.sjcm.20140304.12 DO - 10.11648/j.sjcm.20140304.12 T2 - Science Journal of Clinical Medicine JF - Science Journal of Clinical Medicine JO - Science Journal of Clinical Medicine SP - 65 EP - 69 PB - Science Publishing Group SN - 2327-2732 UR - https://doi.org/10.11648/j.sjcm.20140304.12 AB - Although mycosis fungoides is the most common cutaneous T-cell lymphoma, its etiopathogenesis has not been clarified definitively and there is no standard and curative treatment method. Medical records of 57 patients diagnosed with mycosis fungoides by clinical and histopathological findings were retrospectively reviewed in our clinic. Complete blood count, erythrocyte sedimentation rate, peripheral blood smear, biochemical findings, chest radiographs, and computerized tomography of all patients were reviewed; patients were staged using TNM system. The clinical presentation was classical patch/plaque form in 44patients and other forms in 13. According to TNM staging, 9patients were stage 1a, 38 were stage 1b, 5 were 2a, and 2 were stage 3, and 2 were stage 4a. The pathological findings were basal alignment of lymphocytes, reticular fibroplasia, atypical lymphocytes, and epidermotropism. Remission was achieved by topical imiquimod in 2patients, phototherapy in 30, and phototherapy and systemic treatment in 8. Remission rate with narrow band UV B was 72%, and that of psoralen UV A was 85.71%. Ten patients in remission had recurrence. Age, sex, duration of disease, and clinical presentation had no effect on remission or recurrence of mycosis fungoides. Reticular fibroplasia is a supporting histopathological finding in mycosis fungoides, together with basal alignment of lymphocytes, atypical lymphocytes and epidermotropism. Topical imiquimod treatment for local lesions and phototherapy for widespread lesions are effective, and psoralen UVA treatment seems to be more efficient than narrow band UVB. VL - 3 IS - 4 ER -
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