American Journal of Environmental Protection

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Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance

Received: 31 March 2015    Accepted: 02 April 2015    Published: 25 June 2015
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Abstract

People have different feeling skills of the bitterness of compound phenylthiocarbamide (PTC). This trait has been shown to correlate with a number of dietary preferences and thus may have important implications for human health. There are two types of phenotypes in different ethno groups and populations according to this feature: PTC tester and PTC non-tester. Both phenotypes, besides some rare exceptions, are fixed in almost every population. We have studied the phenotypic variants of feeling the PTC bitterness spread in Georgian ethno group for the first time. Basing on the conducted experiments, about ¾ of the investigated population turned out to be sensitive towards PTC, and ¼ of the population – insensitive. We have analyzed the phenotypic structure of PTC feeling in the people who smoke in the population. The majority of the smokers (70%) turned out to be PTC non-tester and only 30% - PTC tester. It is important to study the phenotypic variants of feelings coded with TAS2R38 gene in the point of view of both – genetic structure of the population and bio-ecology in order to plan different kinds of preventive measures.

DOI 10.11648/j.ajep.s.2015040301.37
Published in American Journal of Environmental Protection (Volume 4, Issue 3-1, May 2015)

This article belongs to the Special Issue Applied Ecology: Problems, Innovations

Page(s) 175-179
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

PTC, Phenotype, Tester, Non-Tester

References
[1] Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet. 2005 Apr;67(4), 275-280.
[2] Bibiana Garcia-Bailo, Clare Toguri, Karen M. Eny, and Ahmed El-Sohemy. Genetic Variation in Taste and Its Influence on Food Selection. OMICS A Journal of Integrative Biology 2009, v. 13(1), pp.69-80
[3] Drewnowski A., Rock CL.The influence of genetic taste markers on food acceptance. Am J Clin Nutr 1995, v.62, pp. 506–511
[4] O.V. Filiptsova, I.A. Timoshyna, Yu.N. Kobets, M.N. Kobets, I.S. Burlaka, I.A. Hurko. The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity. Egyp MedHumGenet.. http://dx.doi.org/10.1016 /j.ejmhg. 2014.12.003. Published online January, 2015
[5] Facchini F., Pettener D., Rimondi A., Sichimbaeva K., Riva P., Salvi P., Pretolani E., Fiori G. Taste sensitivity to PTC and thyroid function (FT4 and TSH) in high- and low-altitude Kirghiz populations in the Pamir Hum Biol. 1994, v. 69(1), 97-106
[6] Cannon DS, Baker TB, Piper ME, Scholand MB, Lawrence DL, Drayna DT, McMahon WM, Villegas GM, Caton TC, Coon H, Leppert MF. Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking. Nicotine Tob Res. 2005, v.7(6), 853-858
[7] Saraswathi YS, Mohsen Najafi, Vineeth VS, Kavitha P, Suttur S. Malini Association of phenylthiocarbamide taste blindness trait with early onset of childhood obesity in Mysore. Journal of Paramedical Sciences. 2011, vol.2 (4), 6-11
[8] Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005, v. 26(3), 199-204
[9] Campa D, Rango F, Carrai M, Crocco, Montesanto A, CanzianF, Rose G, Rizzato C, Giuseppe P, Roberto Barale R. itter Taste Receptor Polymorphisms and Human Aging. PLoS One. 2012; 7(11): e45232.Published online November, 2012
[10] Shivaprasad H.S., Chaithra P.T., Kavitha P., Suttur S. Malini Role of phenylthiocarbamide as a genetic marker in predicting the predisposition of disease traits in Humans. J Nat Sci Biol Med. 2012, v. 3(1), 43–47
Author Information
  • Department, of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia

  • Department, of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia

  • Department, of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia

  • Department, of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia

  • Department, of Biology, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia

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    Rusudan Khukhunaishvili, Marina Koridze, Marina Nagervadze, Ciuri Khizrevanidze, Shorena Gabaidze. (2015). Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. American Journal of Environmental Protection, 4(3-1), 175-179. https://doi.org/10.11648/j.ajep.s.2015040301.37

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    ACS Style

    Rusudan Khukhunaishvili; Marina Koridze; Marina Nagervadze; Ciuri Khizrevanidze; Shorena Gabaidze. Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. Am. J. Environ. Prot. 2015, 4(3-1), 175-179. doi: 10.11648/j.ajep.s.2015040301.37

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    AMA Style

    Rusudan Khukhunaishvili, Marina Koridze, Marina Nagervadze, Ciuri Khizrevanidze, Shorena Gabaidze. Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance. Am J Environ Prot. 2015;4(3-1):175-179. doi: 10.11648/j.ajep.s.2015040301.37

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  • @article{10.11648/j.ajep.s.2015040301.37,
      author = {Rusudan Khukhunaishvili and Marina Koridze and Marina Nagervadze and Ciuri Khizrevanidze and Shorena Gabaidze},
      title = {Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance},
      journal = {American Journal of Environmental Protection},
      volume = {4},
      number = {3-1},
      pages = {175-179},
      doi = {10.11648/j.ajep.s.2015040301.37},
      url = {https://doi.org/10.11648/j.ajep.s.2015040301.37},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajep.s.2015040301.37},
      abstract = {People have different feeling skills of the bitterness of compound phenylthiocarbamide (PTC). This trait has been shown to correlate with a number of dietary preferences and thus may have important implications for human health. There are two types of phenotypes in different ethno groups and populations according to this feature: PTC tester and PTC non-tester. Both phenotypes, besides some rare exceptions, are fixed in almost every population. We have studied the phenotypic variants of feeling the PTC bitterness spread in Georgian ethno group for the first time. Basing on the conducted experiments, about ¾ of the investigated population turned out to be sensitive towards PTC, and ¼ of the population – insensitive. We have analyzed the phenotypic structure of PTC feeling in the people who smoke in the population. The majority of the smokers (70%) turned out to be PTC non-tester and only 30% - PTC tester. It is important to study the phenotypic variants of feelings coded with TAS2R38 gene in the point of view of both – genetic structure of the population and bio-ecology in order to plan different kinds of preventive measures.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Phenotype Variations of TAS2R38 Gene and Its Bioecological Significance
    AU  - Rusudan Khukhunaishvili
    AU  - Marina Koridze
    AU  - Marina Nagervadze
    AU  - Ciuri Khizrevanidze
    AU  - Shorena Gabaidze
    Y1  - 2015/06/25
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajep.s.2015040301.37
    DO  - 10.11648/j.ajep.s.2015040301.37
    T2  - American Journal of Environmental Protection
    JF  - American Journal of Environmental Protection
    JO  - American Journal of Environmental Protection
    SP  - 175
    EP  - 179
    PB  - Science Publishing Group
    SN  - 2328-5699
    UR  - https://doi.org/10.11648/j.ajep.s.2015040301.37
    AB  - People have different feeling skills of the bitterness of compound phenylthiocarbamide (PTC). This trait has been shown to correlate with a number of dietary preferences and thus may have important implications for human health. There are two types of phenotypes in different ethno groups and populations according to this feature: PTC tester and PTC non-tester. Both phenotypes, besides some rare exceptions, are fixed in almost every population. We have studied the phenotypic variants of feeling the PTC bitterness spread in Georgian ethno group for the first time. Basing on the conducted experiments, about ¾ of the investigated population turned out to be sensitive towards PTC, and ¼ of the population – insensitive. We have analyzed the phenotypic structure of PTC feeling in the people who smoke in the population. The majority of the smokers (70%) turned out to be PTC non-tester and only 30% - PTC tester. It is important to study the phenotypic variants of feelings coded with TAS2R38 gene in the point of view of both – genetic structure of the population and bio-ecology in order to plan different kinds of preventive measures.
    VL  - 4
    IS  - 3-1
    ER  - 

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