Clinical Significant Effect of Chloral Hydrate: Diazepam Combination in the Induction of Sedation During Auditory Brainstem Response in Children with Hearing Loss
International Journal of Psychological and Brain Sciences
Volume 1, Issue 2, October 2016, Pages: 32-39
Received: Sep. 6, 2016;
Accepted: Sep. 21, 2016;
Published: Oct. 11, 2016
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Hayder Mutter Al-Kuraishy, Department of clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-mustansiriya University, Baghdad, Iraq
Maryam Mohammed Hammed, B. Sc. College of Pharmacy, Baghdad University, Baghdad, Iraq
Haider W. Alsarhan, Department of Audiology College of Medicine, Al-mustansiriya, University, Baghdad, Iraq
Hearing loss is the most common sensory disability in the world, hearing loss should be early diagnosed and treated since; it leads to speech and language disorders. Auditory brainstem response (ABR) or Auditory evoked potential (AEP) is a neurologic test done by an audiologist to measure auditory evoke potential. Different types of sedation levels are used during auditory brainstem response test. Therefore, the aim of present study was evaluation of the sedative effect of chloral hydrate during auditory brainstem response (ABR) on children with hearing problems. Randomized selection of 160 children with age ranged between 1-5 years with hearing disorders, they were divided into: Group A: Received 20 mg/Kg chloral hydrate orally. Group B: Received 20 mg/Kg chloral hydrate orally plus 0.5 mg/Kg diazepam rectally. Group C: Received 40 mg/Kg chloral hydrate orally. Group D: Received 40 mg/Kg chloral hydrate orally plus 0.5 mg/Kg diazepam rectally. Regarding ABR testing results, positive ABR test was superior in combined group compared to other groups p=0.005 whereas; negative ABR test was low in combined group compared to other groups p=0.006. At the end of ABR testing 118.52±9.88 of testing children in combined group completed the test compared to other groups p=0.0139 while; 98.21±7.22 of testing children in combined group not completed ABR test compared to other groups p=0.005.In conclusion, combined chloral hydrate plus diazepam give more significant sedative effect than chloral hydrate alone during ABR testing in children with hearing disorders.
Hayder Mutter Al-Kuraishy,
Maryam Mohammed Hammed,
Haider W. Alsarhan,
Clinical Significant Effect of Chloral Hydrate: Diazepam Combination in the Induction of Sedation During Auditory Brainstem Response in Children with Hearing Loss, International Journal of Psychological and Brain Sciences.
Vol. 1, No. 2,
2016, pp. 32-39.
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