The effects of estrogen on anxiety-like behaviors results are controversial. Menstrual cycle phase modulates anxiety-related neural function in women have not been sufficiently investigated. The neural base of anxiety possible incongruent across menstrual cycle was investigated in the current study. We studied the neural correlates of anxiety across menstrual cycle approach from cortical evoked magnetic field (MEF) activity under threaten cue stimulus by sLORETA in 14 healthy women. Evaluations included comparisons of the time-course, early vs. late processing (EP: 1-250ms; LP: 251-500ms after stimulus onset) during the menstrual (MC) and peri-ovulatory (OV) phases (MC vs. OV), using dynamic spatio-temporal analysis. Healthy women exhibited dissimilar anxiety–associated patterns of fear neuronal circuitry across menstrual cycle. Analyses revealed significant interaction of the time-course (EP vs. LP) and menstrual cycle phase (MC vs. OV) in the highest anxiety-associated regions. Inversely relation of the anxiety state and insular activation was revealed in the MC vs. OV phase. Results indicated that women can use different attention/cognitive resources in response to fear event across the menstrual cycle. This study presents the first evidence that menstrual cycle phase can modulates anxiety- related neural activation in women. Inconsistent anxiety subtypes may occur at different menstrual cycle. These features are an important consideration in understanding the effect of the menstrual cycle on the neural substrates of anxiety, and provide a potential contribute in pathophysiological or therapeutic implications for menstrual cycle-sensitive psychiatric conditions.
| Published in | International Journal of Psychological and Brain Sciences (Volume 3, Issue 4) |
| DOI | 10.11648/j.ijpbs.20180304.11 |
| Page(s) | 28-39 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Menstrual Cycle, Anxiety, Brain, Go/NoGo
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APA Style
Ren-Jen Hwang, Ying-Chia Lin, Chi-Hsun Wu. (2018). The Neural Basis of Anxiety Across Menstrual Cycle. International Journal of Psychological and Brain Sciences, 3(4), 28-39. https://doi.org/10.11648/j.ijpbs.20180304.11
ACS Style
Ren-Jen Hwang; Ying-Chia Lin; Chi-Hsun Wu. The Neural Basis of Anxiety Across Menstrual Cycle. Int. J. Psychol. Brain Sci. 2018, 3(4), 28-39. doi: 10.11648/j.ijpbs.20180304.11
AMA Style
Ren-Jen Hwang, Ying-Chia Lin, Chi-Hsun Wu. The Neural Basis of Anxiety Across Menstrual Cycle. Int J Psychol Brain Sci. 2018;3(4):28-39. doi: 10.11648/j.ijpbs.20180304.11
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Download@article{10.11648/j.ijpbs.20180304.11,
author = {Ren-Jen Hwang and Ying-Chia Lin and Chi-Hsun Wu},
title = {The Neural Basis of Anxiety Across Menstrual Cycle},
journal = {International Journal of Psychological and Brain Sciences},
volume = {3},
number = {4},
pages = {28-39},
doi = {10.11648/j.ijpbs.20180304.11},
url = {https://doi.org/10.11648/j.ijpbs.20180304.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20180304.11},
abstract = {The effects of estrogen on anxiety-like behaviors results are controversial. Menstrual cycle phase modulates anxiety-related neural function in women have not been sufficiently investigated. The neural base of anxiety possible incongruent across menstrual cycle was investigated in the current study. We studied the neural correlates of anxiety across menstrual cycle approach from cortical evoked magnetic field (MEF) activity under threaten cue stimulus by sLORETA in 14 healthy women. Evaluations included comparisons of the time-course, early vs. late processing (EP: 1-250ms; LP: 251-500ms after stimulus onset) during the menstrual (MC) and peri-ovulatory (OV) phases (MC vs. OV), using dynamic spatio-temporal analysis. Healthy women exhibited dissimilar anxiety–associated patterns of fear neuronal circuitry across menstrual cycle. Analyses revealed significant interaction of the time-course (EP vs. LP) and menstrual cycle phase (MC vs. OV) in the highest anxiety-associated regions. Inversely relation of the anxiety state and insular activation was revealed in the MC vs. OV phase. Results indicated that women can use different attention/cognitive resources in response to fear event across the menstrual cycle. This study presents the first evidence that menstrual cycle phase can modulates anxiety- related neural activation in women. Inconsistent anxiety subtypes may occur at different menstrual cycle. These features are an important consideration in understanding the effect of the menstrual cycle on the neural substrates of anxiety, and provide a potential contribute in pathophysiological or therapeutic implications for menstrual cycle-sensitive psychiatric conditions.},
year = {2018}
}
TY - JOUR T1 - The Neural Basis of Anxiety Across Menstrual Cycle AU - Ren-Jen Hwang AU - Ying-Chia Lin AU - Chi-Hsun Wu Y1 - 2018/10/15 PY - 2018 N1 - https://doi.org/10.11648/j.ijpbs.20180304.11 DO - 10.11648/j.ijpbs.20180304.11 T2 - International Journal of Psychological and Brain Sciences JF - International Journal of Psychological and Brain Sciences JO - International Journal of Psychological and Brain Sciences SP - 28 EP - 39 PB - Science Publishing Group SN - 2575-1573 UR - https://doi.org/10.11648/j.ijpbs.20180304.11 AB - The effects of estrogen on anxiety-like behaviors results are controversial. Menstrual cycle phase modulates anxiety-related neural function in women have not been sufficiently investigated. The neural base of anxiety possible incongruent across menstrual cycle was investigated in the current study. We studied the neural correlates of anxiety across menstrual cycle approach from cortical evoked magnetic field (MEF) activity under threaten cue stimulus by sLORETA in 14 healthy women. Evaluations included comparisons of the time-course, early vs. late processing (EP: 1-250ms; LP: 251-500ms after stimulus onset) during the menstrual (MC) and peri-ovulatory (OV) phases (MC vs. OV), using dynamic spatio-temporal analysis. Healthy women exhibited dissimilar anxiety–associated patterns of fear neuronal circuitry across menstrual cycle. Analyses revealed significant interaction of the time-course (EP vs. LP) and menstrual cycle phase (MC vs. OV) in the highest anxiety-associated regions. Inversely relation of the anxiety state and insular activation was revealed in the MC vs. OV phase. Results indicated that women can use different attention/cognitive resources in response to fear event across the menstrual cycle. This study presents the first evidence that menstrual cycle phase can modulates anxiety- related neural activation in women. Inconsistent anxiety subtypes may occur at different menstrual cycle. These features are an important consideration in understanding the effect of the menstrual cycle on the neural substrates of anxiety, and provide a potential contribute in pathophysiological or therapeutic implications for menstrual cycle-sensitive psychiatric conditions. VL - 3 IS - 4 ER -
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